|1.||Isaacs Syndrome (Neuromyotonia)
|2.||Thymoma (Thymic Carcinoma)
|5.||Myoclonus (Nocturnal Myoclonus)
|1.||Vincent, Angela: 13 articles (11/2014 - 08/2002)|
|2.||Watanabe, Osamu: 7 articles (11/2013 - 01/2002)|
|3.||Vincent, A: 6 articles (10/2014 - 03/2000)|
|4.||Arimura, Kimiyoshi: 6 articles (01/2011 - 01/2002)|
|5.||Kuwabara, Satoshi: 3 articles (01/2015 - 06/2008)|
|6.||Lancaster, Eric: 3 articles (09/2014 - 08/2010)|
|7.||Maljevic, Snezana: 3 articles (01/2014 - 04/2008)|
|8.||Lerche, Holger: 3 articles (01/2014 - 04/2008)|
|9.||Dalmau, Josep: 3 articles (10/2013 - 08/2010)|
|10.||Lang, Bethan: 3 articles (09/2010 - 03/2003)|
08/01/2015 - "In 3 of 5 patients, neuromyotonia was diagnosed by electromyography and positive VGKC antibodies. "
08/01/2015 - "Neuromyotonia (NM), Isaacs-Zschoke-Mertens syndrome or continuous muscle fiber activity (CMFA), is a rare condition associated with VGKC-antibodies. "
11/13/2013 - "Our developed ELISA arrays revealed a specific role for LGI1 antibodies in LE and concomitant involvement of multiple antibodies, including LGI1 antibodies in neuromyotonia, a peripheral nerve disorder. "
01/01/2006 - "Acquired neuromyotonia precipitated by thyroid surgery and associated with antiacetylcholine receptor antibodies."
09/01/2004 - "Mechanism of action of voltage-gated K+ channel antibodies in acquired neuromyotonia."
|2.||Carbamazepine (Tegretol)FDA LinkGeneric
04/01/1969 - "[A case of pseudomyotonia cured by carbamazepine]."
02/01/2013 - "We report the case of a patient with right oculomotor neuromyotonia accompanied by lid ptosis on abduction of the left eye who was successfully treated with oral carbamazepine."
12/01/2008 - "She was diagnosed with ocular neuromyotonia and successfully treated with oral carbamazepine. "
06/01/2007 - "Furthermore, patients with ocular neuromyotonia often benefit from the use of carbamazepine, a membrane-stabilizing agent. "
04/01/1997 - "The neuromyotonia was a delayed effect of radiation therapy and responded to carbamazepine therapy."
|3.||Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA
01/01/2015 - "Isaacs' syndrome was diagnosed based on a positive voltage-gated potassium channel antibody titer of 1,007 pM. "
01/01/2011 - "The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. "
12/15/2008 - "Development of Isaacs' syndrome following complete recovery of voltage-gated potassium channel antibody-associated limbic encephalitis."
01/01/2006 - "In neuromyotonia and cramp-fasciculation syndrome, that are thought to be due to anti-voltage-gated potassium channel abs, signs of peripheral nerve hyperexcitability can be associated with CNS features."
04/01/2005 - "A case of SLE is presented in which muscle twitching and muscle cramps were associated with an autoantibody directed against the voltage-gated potassium channel of peripheral nerves (Isaacs' syndrome)."
02/01/1997 - "Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia."
11/01/1995 - "Acquired neuromyotonia: evidence for autoantibodies directed against K+ channels of peripheral nerves."
06/01/2005 - "Some syndromes such as Lambert-Eaton myasthenic syndrome and neuromyotonia are clearly mediated by autoantibodies. "
05/01/1998 - "The spinal epidural abscess may have triggered the production of these specific autoantibodies, resulting in clinically and electromyographically detectable neuromyotonia."
10/12/1999 - "The coexistence of cramp-fasciculation syndrome and acquired rippling muscle syndrome with MG, thymoma, and neuronal AChR autoantibodies suggests that there is a continuum of autoimmune neuromuscular hyperexcitability disorders related pathogenically to Isaacs syndrome. "
|5.||Immunoglobulin G (IgG)IBA
04/01/1993 - "These clinical data, taken together with the physiological changes observed in mice injected with patients' immunoglobulin G (reported separately), suggest that antibody-mediated autoimmune mechanisms, possibly directed to peripheral nerve K+ channels, may be important in the aetiology of acquired neuromyotonia."
07/13/1991 - "The demonstration of pathogenic IgG autoantibodies in acquired neuromyotonia suggests that immunosuppressive treatment may be helpful in severe cases."
11/01/1995 - "The quantal release of acetylcholine (quantal content) at end-plates in diaphragms from mice treated with neuromyotonia IgG preparations was increased by 21% relative to control values (p = 0.0053). "
11/01/1995 - "The symptoms may improve following plasma exchange, and injection of immunoglobulin G (IgG) from 1 neuromyotonia patient into mice increased the resistance of neuromuscular transmission to d-tubocurarine. "
11/01/1995 - "Here we examine nerves and muscle in vitro from mice injected with plasma or purified IgG from 6 neuromyotonia patients or pooled control subjects, and cultured dorsal root ganglion cells after treatment with IgG. Three of the patients had antibodies against human voltage-gated potassium channels labeled with 125I-alpha-dendrotoxin. "
01/01/1993 - "[Isaacs syndrome: clinical remission after methylprednisolone bolus]."
01/01/2015 - "[A case of Isaacs' syndrome causing various central nervous symptoms successfully treated with high-dose intravenous methylprednisolone therapy]."
01/01/2015 - "This case suggests that high-dose intravenous methylprednisolone therapy for Isaacs' syndrome might be as effective as other immunosuppressive therapies such as plasma exchange or intravenous immunoglobulin. "
|7.||Anticonvulsants (Antiepileptic Drugs)IBA
01/01/1988 - "Both sensory and motor axons are overactive in neuromyotonia, the symptoms of which are relieved by administration of anticonvulsants such as carbamazepine. "
04/01/2013 - "When immunosuppressive therapy is needed, the same considerations apply to LEMS as described for MG. Peripheral nerve hyperexcitability in neuromyotonia can be treated with anticonvulsant drugs such as phenytoin, valproic acid or carbamazepine. "
|8.||gabapentin (Neurontin)FDA LinkGeneric
|9.||Cyclophosphamide (Cytoxan)FDA LinkGeneric
|10.||Potassium Channels (Potassium Channel)IBA
01/01/2013 - "Isaacs' syndrome is an antibody-mediated potassium channel disorder. "
12/01/2006 - "We are presenting 20 cases of the intriguing clinico-electromyographic entity, now considered a potassium channel disorder, Neuromyotonia. "
10/01/2004 - "We conclude that mutations in the potassium channel gene (KCNA1) can cause severe neuromyotonia resulting in marked skeletal deformities even if episodic ataxia is not prominent."
04/01/2010 - "Isaacs' syndrome (immune-mediated neuromyotonia) is an antibody-mediated potassium channel disorder (channelopathy). "
01/01/2002 - "Isaacs' syndrome (acquired neuromyotonia) is an antibody-mediated potassium channel disorder (channelopathy). "
10/01/2000 - "Isaacs' syndrome successfully treated by immunoadsorption plasmapheresis."
01/01/1999 - "We report a case of Isaacs' syndrome showing F-wave hyperexcitability which was reversible after either epidural block or plasmapheresis. "
10/01/1997 - "Double filtration plasmapheresis alleviated the symptoms of neuromyotonia for a short term. "
08/01/1996 - "[Isaacs' syndrome with abnormal F response and effects of double filtration plasmapheresis: a case report]."
10/01/2000 - "We report a 70-year-old woman with Isaacs' syndrome (acquired neuromyotonia) who showed a marked improvement after immunoadsorption plasmapheresis (IAP). "
01/01/2009 - "We describe a patient with startle syndrome and VGKC-Ab, without neuromyotonia or LE, who responded dramatically to plasma exchange (PE) and immunosuppression, adding to the spectrum of disorders associated with VGKC-Ab."
03/01/1997 - "We investigated the pathophysiology of nerve hyperexcitability in a patient with Isaacs' syndrome, who had typical clinical and electromyographic features and responded to plasma exchange. "
04/01/1996 - "Plasma exchange was followed by disappearance of clinical and electrophysiological signs of neuromyotonia and MG, as well as peripheral neuropathy."
04/01/2013 - "Plasma exchange or intravenous immunoglobulin is indicated in severe neuromyotonia and in patients with neuromyotonia combined with central nervous system symptoms, a clinical picture known as Morvan's syndrome."
07/01/1999 - "Acquired neuromyotonia: superiority of plasma exchange over high-dose intravenous human immunoglobulin."
02/01/2013 - "We describe the clinical characteristics of Isaacs' syndrome and its specific considerations in anesthesia."
07/01/2009 - "If patients with neuromyotonia receive anesthesia, we recommend that smaller doses of a nondepolarizing muscle relaxant be administered, accompanied by monitoring of neuromuscular function, so as to provide optimal muscle relaxation while avoiding overdose and prolonged postoperative recovery."
03/01/1997 - "[Acquired neuromyotonia (Isaacs' syndrome): clinical characteristics and anesthesia implications]."
12/01/1997 - "Propofol anesthesia in a patient with Isaacs syndrome--report of a case and literature review."
10/01/2013 - "A report of a single case of a 53-year-old man with myasthenia gravis and a prior thymectomy presenting with 2 months of diffuse, involuntary muscle twitching in the absence of myasthenic symptoms, electrophysiologically confirmed to be neuromyotonia. "
05/01/2007 - "We describe a patient with the diagnoses of acquired neuromyotonia, cutaneous lupus erythematosus and alopecia areata, occurring many years after a thymectomy for myasthenia gravis associated with a thymoma. "
12/01/1999 - "Two months after thymectomy, neuromyotonia associated with hyperhidrosis and mild motor neuropathy occurred and the patient was given plasma-exchange and prednisone therapy. "
06/01/2009 - "Amply reported after external beam radiotherapy, neuromyotonia has not been described after radiosurgery previously. "
07/01/2007 - "In most cases, ocular neuromyotonia follows months or years after radiotherapy to the sellar and parasellar region and involves the oculomotor nerve. "
11/01/1999 - "Localized neuromyotonia of neck muscles after radiotherapy for for nasopharyngeal carcinoma."