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Isaacs Syndrome (Neuromyotonia)

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
Also Known As:
Neuromyotonia; Isaacs-Mertens Syndrome; Pseudomyotonia; Acquired Neuromyotonia; Continuous Muscle Activity Syndrome; Gamstorp-Wohlfart Syndrome; Isaacs' Syndrome; Pseudomyotonia Syndrome of Isaacs; Quantal Squander; Syndrome of Continuous Muscle Activity; Continuous Myokymia; Continuous Myokymias; Gamstorp Wohlfart Syndrome; Gamstorp-Wohlfart Syndromes; Isaac Syndrome; Isaacs Mertens Syndrome; Isaacs Pseudomyotonia Syndrome; Myokymias, Continuous; Neuromyotonia, Acquired; Syndromes, Gamstorp-Wohlfart; Syndromes, Isaacs-Mertens; Myokymia, Continuous
Networked: 194 relevant articles (8 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Isaacs Syndrome (Neuromyotonia)
2. Thymoma (Thymic Carcinoma)
3. Constipation
4. Myokymia
5. Myoclonus (Nocturnal Myoclonus)

Experts

1. Vincent, Angela: 13 articles (11/2014 - 08/2002)
2. Watanabe, Osamu: 7 articles (11/2013 - 01/2002)
3. Vincent, A: 6 articles (10/2014 - 03/2000)
4. Arimura, Kimiyoshi: 6 articles (01/2011 - 01/2002)
5. Kuwabara, Satoshi: 3 articles (01/2015 - 06/2008)
6. Lancaster, Eric: 3 articles (09/2014 - 08/2010)
7. Maljevic, Snezana: 3 articles (01/2014 - 04/2008)
8. Lerche, Holger: 3 articles (01/2014 - 04/2008)
9. Dalmau, Josep: 3 articles (10/2013 - 08/2010)
10. Lang, Bethan: 3 articles (09/2010 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Isaacs Syndrome:
1. AntibodiesIBA
2. Carbamazepine (Tegretol)FDA LinkGeneric
3. Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA
4. AutoantibodiesIBA
5. Immunoglobulin G (IgG)IBA
6. MethylprednisoloneFDA LinkGeneric
7. Anticonvulsants (Antiepileptic Drugs)IBA
8. gabapentin (Neurontin)FDA LinkGeneric
9. Cyclophosphamide (Cytoxan)FDA LinkGeneric
10. Potassium Channels (Potassium Channel)IBA

Therapies and Procedures

1. Plasmapheresis
2. Plasma Exchange
3. Anesthesia
4. Thymectomy
5. Radiotherapy