|1.||Dinarello, Charles A: 48 articles (06/2015 - 03/2002)|
|2.||Okamura, Haruki: 34 articles (01/2016 - 02/2002)|
|3.||Nakanishi, Kenji: 34 articles (01/2011 - 03/2002)|
|4.||Kurimoto, M: 30 articles (12/2001 - 01/2000)|
|5.||Akira, Shizuo: 25 articles (10/2014 - 01/2002)|
|6.||Okamura, H: 24 articles (03/2004 - 01/2000)|
|7.||Tsutsui, Hiroko: 23 articles (05/2013 - 03/2002)|
|8.||Netea, Mihai G: 20 articles (06/2015 - 04/2002)|
|9.||Dinarello, C A: 19 articles (01/2009 - 01/2000)|
|10.||Hoshino, Tomoaki: 18 articles (03/2014 - 02/2002)|
10/01/2007 - "IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in >20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. "
10/01/2006 - "In the present study we investigated the immune mechanism of susceptibility to this type of postburn infection and also examined the efficacy of IL-18 treatment. "
08/01/1999 - "In this study, the efficacy of IL-18 on viral infection in mice was investigated. "
07/01/2011 - "We investigated the efficacy of interleukin-18 (IL-18) treatment in postburn MRSA infection. "
04/01/2010 - "We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. "
06/01/2012 - "Neutralization of IL-18 by RNA interference in tumors or systemically by IL-18-binding protein dramatically reduced the accumulation of Kit(+)CD11b(-) NK cells in tumor bearers. "
10/01/2014 - "Moreover, established distant tumors were completely eradicated by vaccination with the IL-18 and HSV-TK transfectants in combination with GCV. "
10/01/2014 - "Large established tumors of colon 26 transfectants expressing IL-18 and HSV-TK driven by the hTERT promoter were completely eradicated after GCV administration in syngeneic BALB/c mice. "
03/01/2002 - "Construction and analysis of new vector systems with improved interleukin-18 secretion in a xenogeneic human tumor model."
12/01/2006 - "In this article we investigated whether IL-18 genetic modification of tumor cells can increase the efficacy of exosomes derived from IL-18 gene-modified tumor cells. "
|3.||Melanoma (Melanoma, Malignant)
04/01/2001 - "Intratumoral IL-18 gene transfer improves therapeutic efficacy of antibody-targeted superantigen in established murine melanoma."
01/01/2010 - "A phase II study of IL-18 in patients with metastatic melanoma confirmed its safety but suggested limited efficacy of IL-18 monotherapy in this setting. "
11/15/2006 - "An exogenous IL-18 treatment improved the ability of the B16F10/IL-18 antisense transfectant cells to migrate, indicating that IL-18 enhanced the migration ability of melanoma cells. "
11/15/2006 - "This study investigated the effect of IL-18 on the ability of murine melanoma cells to migrate by using B16F10 cells and the IL-18 antisense transfectants of B16F10 cells (the B16F10/IL-18 antisense transfectant). "
09/01/2002 - "In this study, we investigated whether the introduction of the interleukin-18 gene to B16F10 melanoma cells can induce antitumor response or not. "
07/01/2007 - "In the colitis patients, mean free IL-18 level and IL-18BP were significantly different between healthy individuals and patients, but not between disease remission and exacerbation (167 +/- 32, 492 +/- 247 and 451 +/- 69 pg/ml for IL-18, and 2.1 +/- 1.1, 7.69 +/- 4 and 6.8 +/- 7 ng/ml for IL-18BP, respectively, P= 0.05). "
02/01/2012 - "Remarkably, several reports have demonstrated that immunological or genetic blockage of IL-18 ameliorates the severity of colitis in multiple in vivo models of IBD. "
09/01/2011 - "The aim of this study was to establish a model of murine colitis exacerbated by psychological stress and to clarify the role of IL-18 in this model. "
12/03/2015 - "Colitis and goblet cell loss were rescued in Il18bp(-/-);Il18r(Δ/EC) mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. "
12/03/2015 - "In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. "
10/15/2002 - "Nevertheless, a single IL-18 injection into mice simultaneously with LPS was no longer effective in the restoration of serum IFN-gamma and IFN-gamma production from the liver MNC at 7 days after burn injury, when mice were considered to be the most immunocompromised. "
01/01/2015 - "The aim of our study was to determine whether combined KIM-1 and IL-18 are more sensitive than traditional markers in detecting kidney injury in patients with burns. "
01/01/2011 - "The purpose of this study was to examine whether EtOH intoxication combined with burn injury influences neutrophil apoptosis and whether IL-18 plays any role in this setting. "
08/01/2015 - "Levels of IL-18 were increased by ∼1.5-fold in the colon as compared to the ileum following alcohol and burn injury. "
01/01/2015 - "Our results suggest that urinary KIM-1 and IL-18 may be used as early, sensitive indicators of AKI in patients with burns of varying degrees and provide clinical clues that can be used in early prevention of AKI."
|1.||Interleukin-12 (IL 12)
|2.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|4.||Messenger RNA (mRNA)
|6.||DNA (Deoxyribonucleic Acid)
|7.||Carrier Proteins (Binding Protein)
|9.||Interleukin-10 (Interleukin 10)
|10.||Interferon-gamma (Interferon, gamma)