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Paraneoplastic Cerebellar Degeneration

Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
Also Known As:
Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndrome, Paraneoplastic; Paraneoplastic Cerebellar Syndrome; Anti Yo Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndromes, Paraneoplastic; Degeneration, Paraneoplastic Cerebellar; Paraneoplastic Cerebellar Degeneration, Anti Yo Associated; Paraneoplastic Cerebellar Syndromes; Cerebellar Degeneration, Paraneoplastic; Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated
Networked: 185 relevant articles (6 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome)
2. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
3. Neoplasms (Cancer)
4. Hodgkin Disease (Hodgkin's Disease)
5. Paraneoplastic Syndromes (Paraneoplastic Syndrome)

Experts

1. Graus, F: 12 articles (05/2014 - 09/2000)
2. Graus, Francesc: 11 articles (04/2015 - 10/2004)
3. Dalmau, Josep: 10 articles (08/2014 - 12/2006)
4. Sabater, Lidia: 7 articles (08/2014 - 10/2004)
5. Honnorat, J: 6 articles (05/2014 - 01/2003)
6. Saiz, Albert: 5 articles (01/2013 - 10/2004)
7. Greenlee, John E: 4 articles (01/2015 - 04/2010)
8. Höftberger, Romana: 4 articles (01/2015 - 01/2013)
9. Vedeler, Christian A: 4 articles (12/2014 - 10/2004)
10. Giometto, B: 4 articles (05/2014 - 07/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paraneoplastic Cerebellar Degeneration:
1. AntibodiesIBA
2. AutoantibodiesIBA
3. metabotropic glutamate receptor type 1IBA
4. AntigensIBA
5. Calcium Channels (Calcium Channel)IBA
6. Complementary DNA (cDNA)IBA
7. HLA-A2 Antigen (HLA A2 Antigen)IBA
8. Surface Antigens (Surface Antigen)IBA
9. EpitopesIBA
10. PeptidesIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Plasmapheresis
3. Immunomodulation
4. Ovariectomy (Oophorectomy)
5. Plasma Exchange