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Paraneoplastic Cerebellar Degeneration

Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
Also Known As:
Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndrome, Paraneoplastic; Paraneoplastic Cerebellar Syndrome; Anti Yo Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndromes, Paraneoplastic; Degeneration, Paraneoplastic Cerebellar; Paraneoplastic Cerebellar Degeneration, Anti Yo Associated; Paraneoplastic Cerebellar Syndromes; Cerebellar Degeneration, Paraneoplastic; Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated
Networked: 298 relevant articles (9 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome)
2. Neoplasms (Cancer)
3. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
4. Cerebellar Ataxia (Dysmetria)
5. Hodgkin Disease (Hodgkin's Disease)

Experts

1. Graus, Francesc: 13 articles (01/2019 - 01/2003)
2. Dalmau, Josep: 10 articles (08/2014 - 01/2003)
3. Graus, F: 10 articles (05/2014 - 09/2000)
4. Haugen, Mette: 8 articles (01/2022 - 02/2011)
5. Sabater, Lidia: 8 articles (01/2019 - 10/2004)
6. Honnorat, Jérôme: 7 articles (01/2022 - 03/2010)
7. Vedeler, Christian A: 7 articles (11/2020 - 10/2004)
8. Vedeler, Christian: 5 articles (01/2022 - 05/2004)
9. Mitoma, Hiroshi: 5 articles (05/2021 - 01/2015)
10. Greenlee, John E: 5 articles (01/2020 - 04/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paraneoplastic Cerebellar Degeneration:
1. AntibodiesIBA
2. anti-Yo autoantibodiesIBA
3. AutoantibodiesIBA
4. metabotropic glutamate receptor type 1IBA
5. AntigensIBA
6. Proteins (Proteins, Gene)FDA Link
7. Peptides (Polypeptides)IBA
8. EpitopesIBA
9. Calcium Channels (Calcium Channel)IBA
10. Complementary DNA (cDNA)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Immunotherapy
3. Plasmapheresis
4. Immunomodulation
5. Activities of Daily Living (ADL)