Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
Also Known As:
Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndrome, Paraneoplastic; Paraneoplastic Cerebellar Syndrome; Anti Yo Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndromes, Paraneoplastic; Degeneration, Paraneoplastic Cerebellar; Paraneoplastic Cerebellar Degeneration, Anti Yo Associated; Paraneoplastic Cerebellar Syndromes; Cerebellar Degeneration, Paraneoplastic; Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated