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Optic Nerve Glioma

Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus. (Adams et al., Principles of Neurology, 6th ed, p681)
Also Known As:
Adult Optic Nerve Glioma; Childhood Optic Nerve Glioma; Glioma, Optic Nerve, Adult; Glioma, Optic Nerve, Childhood; Malignant Optic Nerve Astrocytoma; Optic Glioma; Optic Nerve Glioma, Adult; Optic Nerve Glioma, Childhood; Optic Nerve, Malignant Astrocytoma; Glioma, Optic; Gliomas, Optic; Gliomas, Optic Nerve; Optic Gliomas; Optic Nerve Gliomas; Astrocytoma, Malignant, Optic Nerve; Glioma, Optic Nerve; Malignant Astrocytoma, Optic Nerve
Networked: 104 relevant articles (7 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Glioma (Gliomas)
3. Moyamoya Disease (Moya-Moya Disease)
4. Metaplasia
5. Neurofibromatosis 1 (Neurofibromatosis Type I)

Experts

1. Gutmann, David H: 12 articles (10/2015 - 05/2007)
2. Gianino, Scott M: 7 articles (06/2015 - 12/2008)
3. Toonen, Joseph A: 3 articles (10/2015 - 05/2015)
4. Riccardi, Riccardo: 3 articles (04/2015 - 05/2011)
5. Falsini, Benedetto: 3 articles (04/2015 - 05/2011)
6. Chiaretti, Antonio: 3 articles (04/2015 - 05/2011)
7. Garbow, Joel R: 3 articles (07/2010 - 05/2007)
8. Rubin, Joshua B: 3 articles (07/2010 - 09/2007)
9. Daginakatte, Girish C: 3 articles (12/2008 - 05/2007)
10. Pong, Winnie W: 2 articles (10/2015 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Optic Nerve Glioma:
1. Retinaldehyde (Retinal)IBA
2. Neutralizing AntibodiesIBA
3. Mucin-1 (CA 15-3 Antigen)IBA
4. Reticulin (Reticular Fiber)IBA
5. Glial Fibrillary Acidic ProteinIBA
6. Sirolimus (Rapamycin)FDA Link
7. VimentinIBA
8. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
9. Phosphopyruvate Hydratase (Enolase)IBA
10. Peroxidase (Myeloperoxidase)IBA

Therapies and Procedures

1. Radiotherapy
2. Drug Therapy (Chemotherapy)
3. Decompression
4. Ventriculoperitoneal Shunt
5. Cranial Irradiation