Optic Nerve Glioma

Glial cell derived tumors arising from the optic nerve, usually presenting in childhood.

Also Known As:

Adult Optic Nerve Glioma; Childhood Optic Nerve Glioma; Glioma, Optic Nerve, Adult; Glioma, Optic Nerve, Childhood; Malignant Optic Nerve Astrocytoma; Optic Glioma; Optic Nerve Glioma, Adult; Optic Nerve Glioma, Childhood; Optic Nerve, Malignant Astrocytoma; Glioma, Optic; Gliomas, Optic; Gliomas, Optic Nerve; Optic Gliomas; Optic Nerve Gliomas; Astrocytoma, Malignant, Optic Nerve; Glioma, Optic Nerve; Malignant Astrocytoma, Optic Nerve

Networked: 142 relevant articles (9 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Glioma (Gliomas)
3.	Neurofibromatoses (Neurofibromatosis)
4.	Precocious Puberty
5.	Moyamoya Disease (Moya-Moya Disease)

Experts

1.	Gutmann, David H: 24 articles (01/2022 - 11/2005)
2.	Gianino, Scott M: 9 articles (01/2016 - 12/2008)
3.	Toonen, Joseph A: 8 articles (08/2017 - 05/2015)
4.	Chiaretti, Antonio: 5 articles (09/2021 - 05/2011)
5.	Garbow, Joel R: 4 articles (12/2021 - 05/2007)
6.	Pan, Yuan: 4 articles (10/2019 - 04/2017)
7.	Ma, Yu: 4 articles (08/2017 - 01/2017)
8.	Solga, Anne C: 4 articles (08/2017 - 10/2015)
9.	Falsini, Benedetto: 4 articles (02/2016 - 05/2011)
10.	Riccardi, Riccardo: 4 articles (02/2016 - 05/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Optic Nerve Glioma:

1.	Retinaldehyde (Retinal)IBA 01/01/2016 - "Optical coherence tomography has given new insight on retinal alterations and is a noninvasive tool in the management of optic nerve gliomas in children. " 05/01/2015 - "In addition, all 3 Nf1 murine optic glioma strains exhibited reduced retinal ganglion cell survival and numbers; however, FMPC mice had greater retinal nerve fiber layer thinning near the optic head relative to FMC and FMBC mice. " 04/01/2015 - "To determine whether the Ganzfeld ERG photopic negative response (PhNR), an assay of inner retinal activity, is altered in childhood optic glioma (OPG). " 02/01/2011 - "We report a case of a 16-year-old girl with KTS who was found to have bilateral optic nerve and chiasmal gliomas, optic disk drusen, and acquired myelination of the retinal nerve fiber layer. " 07/01/2009 - "Multiple wedge-shaped retinal nerve fiber layer defects in a patient with optic nerve glioma in the contralateral eye: case report."
2.	Neutralizing AntibodiesIBA 01/01/2022 - "CD11a-deficient mouse microglia were used for in vitro functional studies, while LGG growth in mice was assessed using anti-CD11a neutralizing antibody treatment of Neurofibromatosis type 1 (Nf1) optic glioma mice in vivo. " 10/01/2015 - "Importantly, consistent with its critical role in maintaining tumor growth, treatment with Ccl5 neutralizing antibodies reduced Nf1 mouse optic glioma growth and improved retinal dysfunction in vivo. "
3.	Glial Fibrillary Acidic ProteinIBA 01/01/2016 - "Importantly, only R681X(CKO) but not G848R(CKO), mice develop optic gliomas with increased optic nerve volumes, glial fibrillary acid protein immunoreactivity, proliferation and retinal ganglion cell death, similar to Nf1 conditional knockout mice harboring a neomycin insertion (neo) as the germline Nf1 gene mutation. " 01/01/2014 - "Reticulin stain, immunochemistry with glial fibrillary acid protein (GFAP), epithelial membrane antigen (EMA), and S-100 helped to arrive at the final diagnosis of optic glioma displaying exuberant arachnoid proliferation with cartilaginous metaplasia. "
4.	Mucin-1 (CA 15-3 Antigen)IBA 01/01/2014 - "Reticulin stain, immunochemistry with glial fibrillary acid protein (GFAP), epithelial membrane antigen (EMA), and S-100 helped to arrive at the final diagnosis of optic glioma displaying exuberant arachnoid proliferation with cartilaginous metaplasia. "
5.	SteroidsIBA 12/01/1989 - "Optic nerve decompression or short-term high-dose steroid therapy, or both, may be helpful in recovering visual function in selected patients with optic nerve gliomas who have acute visual loss."
6.	Reticulin (Reticular Fiber)IBA 01/01/2014 - "Reticulin stain, immunochemistry with glial fibrillary acid protein (GFAP), epithelial membrane antigen (EMA), and S-100 helped to arrive at the final diagnosis of optic glioma displaying exuberant arachnoid proliferation with cartilaginous metaplasia. "
7.	Coloring Agents (Dyes)IBA 01/01/2014 - "Reticulin stain, immunochemistry with glial fibrillary acid protein (GFAP), epithelial membrane antigen (EMA), and S-100 helped to arrive at the final diagnosis of optic glioma displaying exuberant arachnoid proliferation with cartilaginous metaplasia. "
8.	Proteins (Proteins, Gene)FDA Link 08/01/2017 - "We sought to investigate biological function and protein structure of the myxoid matrix in optic gliomas to identify novel therapeutic targets. " 06/24/2020 - "We report a case of an 11-year-old boy with high cerebrospinal fluid protein hydrocephalus secondary to optic glioma that required a ventriculoperitoneal (VP) shunt. " 10/21/2016 - "3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma." 11/01/2005 - "As part of a larger effort to identify protein markers for NF1-associated astrocytomas that could be exploited for therapeutic drug design, we did an objective proteomic analysis of the cerebrospinal fluid from genetically engineered Nf1 mice with optic glioma. " 01/01/1994 - "For patients diagnosed with optic gliomas, it is suggested that because the tumor is widely exposed to the CSF space, protein exuded by the mass into the subarachnoid space will cause an elevated CSF protein concentration. "
9.	Nerve Growth Factor (NGF)IBA 09/01/2021 - "Further, promising pharmacologic effects were reported in an optic glioma model, which indicated that topically administered nerve growth factor diffused far beyond where it was topically applied. " 02/01/2016 - "Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial." 07/01/2011 - "Topical nerve growth factor as a visual rescue strategy in pediatric optic gliomas: a pilot study including electrophysiology." 05/01/2011 - "Nerve growth factor eye drop administration improves visual function in a patient with optic glioma." 01/01/2018 - "These studies revealed that NGF possesses important therapeutic properties, after topical administration, on human cutaneous pressure ulcer, corneal ulcers, glaucoma, retinal maculopathy, Retinitis Pigmentosa and in pediatric optic gliomas and brain traumas. "
10.	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 06/01/2015 - "This study was designed to address the importance of MEK and Akt signaling to Nf1 optic glioma growth. " 06/01/2015 - "Finally, both PI3K and MEK inhibition reduced optic glioma-associated retinal ganglion cell loss and nerve fiber layer thinning. " 06/01/2015 - "Sustained MEK pharmacologic blockade also attenuated Nf1-deficient astrocytes as well as Nf1 optic glioma volume and proliferation. " 06/01/2015 - "Both MEK and Akt were hyperactivated in Nf1-deficient astrocytes in vitro and in Nf1 murine optic gliomas in vivo. " 06/01/2015 - "Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth."

Therapies and Procedures

1.	Radiotherapy 06/01/1985 - "In view of the substantial morbidity and mortality in reported series, and the tendency for referral of more serious cases to a radiotherapy center, we conclude from our results that radiotherapy is effective in preventing progression of optic glioma, and that treatment early in the course of the disease is indicated to minimize the associated visual deficit." 01/01/2022 - "To evaluate safety and efficacy of hypofractionated radiotherapy in patients with optic nerve glioma. " 01/01/1987 - "Twenty-five children with optic gliomas were evaluated over a seven year period by sequential computed axial tomography in order to determine the efficacy of radiotherapy as a treatment modality. " 01/01/1987 - "Efficacy of radiotherapy in optic gliomas." 01/01/2021 - "This 35-year-old patient had familial NF1 and a history of optic glioma treated with radiation therapy (RT). "
2.	Therapeutics 03/01/2008 - "Collectively, these findings suggest that this Nf1 optic glioma model may be a potential preclinical benchmark for identifying novel therapies that have a high likelihood of success in human clinical trials." 07/01/2011 - "To date, no specific therapy is available for optic glioma (OG)-induced visual loss. " 01/01/1996 - "Gamma Knife radiosurgery could be an effective adjuvant therapy for low-grade optic glioma. " 05/01/1991 - "CT-stereotactic biopsy to verify the diagnosis with subsequent interstitial irradiation is presented as an alternative therapy for optic gliomas." 09/01/1990 - "These data indicate that the high dose of cranial radiation used to treat optic glioma invariably results in GH deficiency within 2 years and that hGH therapy is required when GH deficiency is documented.(ABSTRACT TRUNCATED AT 250 WORDS)"
3.	Drug Therapy (Chemotherapy) 06/24/2022 - "The patient was diagnosed with optic nerve gliomas and chemotherapy was initiated. " 01/01/2020 - "At the age of 4 years, the child required chemotherapy to treat symptomatic bilateral optic glioma. " 01/01/2015 - "Her right eye was amblyopic because of an optic nerve glioma treated in childhood with chemotherapy. " 05/01/2012 - "A five-year-old boy received a clinical diagnosis of optic nerve glioma, and was followed-up for three months after chemotherapy. " 12/01/1985 - "Chiasmatic optic glioma treated with chemotherapy. "
4.	Decompression 12/01/1989 - "Optic nerve decompression or short-term high-dose steroid therapy, or both, may be helpful in recovering visual function in selected patients with optic nerve gliomas who have acute visual loss."
5.	Topical Administration 01/01/2018 - "These studies revealed that NGF possesses important therapeutic properties, after topical administration, on human cutaneous pressure ulcer, corneal ulcers, glaucoma, retinal maculopathy, Retinitis Pigmentosa and in pediatric optic gliomas and brain traumas. "