Essential Tremor (Essential Tremors)

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516 relevant articles (72 outcomes, 100 trials/studies) found for this Disease

Description: A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)

Also Known As:

Essential Tremors; Tremor, Essential; Benign Essential Tremor; Familial Tremor; Benign Essential Tremors; Essential Tremor, Benign; Essential Tremors, Benign; Familial Tremors; Tremor, Benign Essential; Tremor, Familial; Tremors, Benign Essential; Tremors, Essential; Tremors, Familial

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3406

Central Nervous System Diseases: 929

Movement Disorders: 1472

Essential Tremor: 516

Related Diseases

1.	Tremor (Tremors)
2.	Parkinson Disease (Parkinson's Disease)
3.	Dystonia (Limb Dystonia)
4.	Movement Disorders (Movement Disorder)
5.	Angina Pectoris
92 Diseases and 244 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Zesiewicz, Theresa A: 9 articles (01/2008 - 05/2005)
2.	Louis, Elan D: 8 articles (09/2008 - 11/2002)
3.	Sullivan, Kelly L: 8 articles (01/2008 - 05/2005)
4.	Hauser, Robert A: 7 articles (01/2008 - 05/2005)
5.	Ward, Christopher L: 6 articles (01/2008 - 08/2006)
6.	Factor-Litvak, Pam: 4 articles (09/2008 - 05/2004)
7.	Zheng, Wei: 4 articles (09/2008 - 08/2007)
8.	Louis, E D: 4 articles (12/2005 - 12/2002)
9.	Jiang, Wendy: 3 articles (09/2008 - 03/2008)
10.	Rios, Eileen: 3 articles (09/2008 - 03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Essential Tremor:

1.	Propranolol (Inderal)FDA LinkGeneric 02/01/1983 - "These results indicate that a single oral dose of propranolol is effective in producing a rapid and marked reduction of essential tremor" 05/01/1990 - "Clinical and computer-based assessment of long-term therapeutic efficacy of propranolol in essential tremor." 11/06/1976 - "In a double-blind crossover study 12 patients with essential tremor were treated with propranolol and a placebo; 8 improved with propranolol and 3 with the placebo; the degree of improvement with propranolol was greater" 11/06/1975 - "Peripheral beta-adrenergic tremorogenic receptors function normally even in patients with essential tremor; their function is not necessary for the production of essential tremor, and the efficacy of chronic propranolol therapy in the suppression of essential tremor is not mediated via its peripheral beta-adrenergic blocking action." 03/01/2004 - "The aim of our study is to report the clinical response to long action propranolol (LAP) of 40 patients diagnosed with essential tremor with no previous treatment" Get all the results and reference details, order at left...
2.	Primidone (Sertan)FDA LinkGeneric 01/17/1981 - "Primidone is highly effective in benign familial tremor" 09/01/1985 - "Uncontrolled clinical studies have suggested that primidone may be effective in reducing essential tremor thus providing a valuable alternative to beta-adrenoreceptor antagonists which are currently the drugs of first choice" 02/01/1990 - "The long-term efficacy of primidone (375-750 mg/day) in essential tremor was evaluated prospectively in 11 patients who had shown a favorable response to 4-week treatment with the drug under placebo-controlled conditions" 01/01/1986 - "Primidone is an effective agent for the treatment of essential tremor." 01/01/1986 - "Efficacy of primidone in essential tremor." Get all the results and reference details, order at left...
3.	topiramate (Topamax)FDA Link 03/14/2006 - "In small trials, topiramate appeared to be beneficial in essential tremor" 09/01/2006 - "Is the anticonvulsant topiramate beneficial in essential tremor?" 03/14/2006 - "CONCLUSIONS: Topiramate was effective in the treatment of moderate to severe essential tremor" 11/01/2003 - "Low doses of topiramate are effective in essential tremor: a report of three cases." 03/01/2006 - "The antiepileptic drug topiramate has been reported to improve essential tremor, but clinical trials have been small and of unsatisfactory design" Get all the results and reference details, order at left...
4.	gabapentin (Neurontin)FDA LinkGeneric 05/01/1998 - "Gabapentin has been reported to be effective for essential tremor (ET) based on open-label trials" 04/01/1999 - "CONCLUSION: Gabapentin may be useful for the treatment of essential tremor." 07/01/2000 - "Gabapentin for essential tremor: a multiple-dose, double-blind, placebo-controlled trial." 04/01/1999 - "OBJECTIVE: To study the effects of gabapentin in a comparative, double-blind, crossover, placebo-controlled trial of patients who have essential tremor" 05/01/1998 - "Double-blind controlled trial of gabapentin in essential tremor." Get all the results and reference details, order at left...
5.	Metoprolol (Lopressor)FDA LinkGeneric 07/01/1986 - "Metoprolol possesses the ability to blunt the tremorgenic response to mental stress in patients with essential tremor, but the duration of this effect lasts less than seven hours after administration of a dose." 07/01/1986 - "We have studied the ability of metoprolol tartrate to attenuate specifically the tremorgenic response to mental stress in five patients with essential tremor who were each studied on four occasions" 07/01/1986 - "Attenuation of response to mental stress in patients with essential tremor treated with metoprolol." 09/01/1984 - "Data suggest that the alpha-hydroxymetabolite of metoprolol may contribute to the reduction in essential tremor." 11/28/1981 - "Metoprolol in essential tremor." Get all the results and reference details, order at left...
6.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2006 - "Botulinum toxin is effective for essential tremor of the voice and head" 12/01/2000 - "This study aimed to improve botulinum toxin's (BTX) efficacy and to reduce its unwanted effects in the treatment of functional disability due to essential tremor (ET) of the hand" 12/01/2000 - "Botulinum toxin treatment for functional disability induced by essential tremor." 12/01/1998 - "The results are also consistent with botulinum toxin having a beneficial effect in patients with essential tremor" 12/01/1998 - "We studied the effect of botulinum toxin A injection on the abnormal presynaptic phase of reciprocal inhibition between forearm antagonist muscles in patients with essential tremor" Get all the results and reference details, order at left...
7.	Alprazolam (Xanax)FDA LinkGeneric 02/01/1988 - "Efficacy of alprazolam for essential tremor." 02/01/1988 - "The effect of alprazolam on essential tremor was examined by a double-blind, placebo-controlled parallel study of 24 patients" 10/01/2006 - "CASE SUMMARY: A 40-year-old woman with a history of substance abuse complicated by essential tremor and neuropathic pain was admitted to our addictions unit with altered mental state due to escalating use of alprazolam" 10/01/2006 - "Apparently, her essential tremor had responded inadequately to propranolol, but had responded well to alprazolam" 10/01/2000 - "New alternative agents in essential tremor therapy: double-blind placebo-controlled study of alprazolam and acetazolamide." Get all the results and reference details, order at left...
8.	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 08/01/1983 - "In order to elucidate the mode of action of beta-adrenoreceptor antagonists in essential tremor, the efficacy of chronic oral administration of metoprolol, atenolol and sotalol was compared in a randomised, double-blind placebo controlled trial in twenty-four patients" 08/01/1983 - "Beta-adrenoreceptor mechanisms in essential tremor; a double-blind placebo controlled trial of metoprolol, sotalol and atenolol." 10/01/1979 - "Three different beta-adrenoreceptor antagonists--propranolol, sotalol, and atenolol--were compared in a double-blind study with placebo in nine patients with essential tremor" 10/01/1985 - "Propranolol and sotalol produced equal maximal inhibition of isoprenaline-induced tremor but propranolol was significantly more effective in reducing essential tremor" Get all the results and reference details, order at left...
9.	Botulinum Toxin Type A (Botox)FDA Link 06/12/2001 - "OBJECTIVE: To evaluate the safety and efficacy of botulinum toxin type A injection in essential tremor of the hand" 06/12/2001 - "METHODS: One hundred thirty-three patients with essential tremor were randomized to low-dose (50 U) or high-dose (100 U) botulinum toxin type A (Botox) or vehicle placebo treatment" 06/12/2001 - "CONCLUSION: Botulinum toxin type A injections for essential tremor of the hands resulted in significant improvement of postural, but not kinetic, hand tremors and resulted in limited functional efficacy" 08/01/2000 - "OBJECTIVES/HYPOTHESIS: To evaluate the relative efficacy of unilateral and bilateral injections of botulinum toxin injection (BOTOX) in the treatment of essential tremor of the voice (ETV)" Get all the results and reference details, order at left...
10.	etiracetam (levetiracetam)FDA Link 11/01/2007 - "CONCLUSIONS: Levetiracetam is not beneficial in the treatment of essential tremor." 11/01/2007 - "METHODS: Fifteen patients (3 women), aged 35 to 83 years, with essential tremor were studied in a double-blind, placebo-controlled crossover trial of levetiracetam" 08/01/2007 - "Effectiveness and safety of levetiracetam in patients with essential tremor: data from an open 11-week follow-up trial]" 03/22/2005 - "The effect of a single dose of 1,000 mg of levetiracetam on essential tremor was investigated in 24 patients in a double-blind, placebo-controlled trial" 11/01/2004 - "The objective of this study was to determine whether levetiracetam warrants further investigation as a treatment of essential tremor (ET)" Get all the results and reference details, order at left...
211 Drugs and Important Bio-Agents and 382 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Deep Brain Stimulation 03/01/2005 - "Deep brain stimulation is the best option for patients with disabling, drug-resistant essential tremor" 04/01/2003 - "Thalamic deep brain stimulation (DBS) has been demonstrated to be effective for the treatment of parkinsonian or essential tremor" 07/01/2000 - "Deep brain stimulation (DBS) of the ventralis intermedius nucleus (Vim) is a safe and effective treatment for essential tremor" 10/01/2008 - "Factors involved in long-term efficacy of deep brain stimulation of the thalamus for essential tremor." 05/01/2001 - "Our objective was to investigate the long-term safety and efficacy of unilateral deep brain stimulation (DBS) of the VIM nucleus of the thalamus in essential tremor" Get all the results and reference details, order at left...
2.	Drug Therapy (Chemotherapy) 01/01/1995 - "In conclusion we regard Vim neurostimulation as an effective and safe alternative to conventional thalamotomy and recommend that it should be considered in cases in which drug therapy has failed to affect Parkinsonian or essential tremor" 01/01/2008 - "Pharmacotherapy of essential tremor : an overview of existing and upcoming agents." 11/01/2007 - "This concept has broad implications for understanding the mechanism and designing rationale pharmacotherapy for abnormal oscillations and may be applicable to other common disorders in which there are no structural abnormalities in the brain such as essential tremor." 03/01/2005 - "This genetic animal model elucidates a mechanism of GABAergic dysfunction in the major motor pathway and potential targets for pharmacotherapy of essential tremor." 07/01/1986 - "Essential tremor is not a benign condition; disability can be only partly reversed with drug therapy." Get all the results and reference details, order at left...
3.	Electrodes (Electrode) 07/01/2000 - "The goal in this study was to correlate the location of the electrodes with the clinical efficacy of DBS in a patient with essential tremor" 02/01/2008 - "CONCLUSION: Optimal electrode location for thalamic DBS in essential tremor corresponds to the anterior margin of the ventralis intermedius nucleus" 05/01/2004 - "CONCLUSION: Optimal electrode location for thalamic DBS in essential tremor corresponds to the anterior margin of the ventralis intermedius nucleus" 02/01/2003 - "In patients with electrodes in the thalamic ventrointermediate nucleus (VIM) for the treatment of essential tremor (ET) here we show that variations in voltage and frequency of thalamic stimulation have differential effects in a thalamo-cortical circuitry" 12/01/2001 - "In a patient with unilateral severe essential tremor, the authors implanted two electrodes side by side and parallel to each other in the unilateral thalamic ventralis intermedius nucleus" Get all the results and reference details, order at left...
4.	Transcutaneous Electric Nerve Stimulation (TENS) 02/01/2003 - "Based on the claims that transcutaneous electrical nerve stimulation is effective in myoclonic dystonia and essential tremor, we evaluated its acute effects in 5 patients with essential tremor and 2 patients with tremor attributed to peripheral neuropathy using as parameters the Washington Heights-Inwood Genetic Study of Essential Tremor rating scale, self-reported impression, and recording of electromyographic activity" Get all the results and reference details, order at left...
5.	Activities of Daily Living (ADL) 01/01/2002 - "CONCLUSIONS: After thalamic DBS, health-related quality of life including disability in ADL and social life were improved in patients with essential tremor." 06/01/2003 - "The impact of thalamic stimulation on activities of daily living for essential tremor." 03/01/2006 - "We undertook a double-blind, placebo-controlled crossover study of topiramate in essential tremor, using accelerometry, spirography, and an activities of daily living questionnaire" Get all the results and reference details, order at left...
22 Therapies and Procedures and 141 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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