Migraine with Aura (Familial Hemiplegic Migraine)

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394 relevant articles (26 outcomes, 53 trials/studies) found for this Disease

Description: A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Also Known As:

Familial Hemiplegic Migraine; Hemiplegic Migraine, Familial; Classical Migraine; Migraine, Classical; Complicated Migraine; Acute Onset Aura Migraine; Basilar Artery Migraine; Basilar Migraine; Migraine Aura without Headache; Migraine with Acute Onset Aura; Migraine with Prolonged Aura; Migraine with Typical Aura; Migraine, Prolonged Aura; Typical Aura without Headache; Basilar Migraines; Basilar Type Migraine; Familial Hemiplegic Migraines; Migraine with Auras; Migraine, Basilar; Migraine, Basilar Artery; Migraine, Basilar-Type; Migraine, Complicated; Prolonged Aura Migraine; Basilar-Type Migraine; Classic Migraine; Migraine, Classic

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3406

Central Nervous System Diseases: 929

Brain Diseases: 1117

Headache Disorders: 425

Primary Headache Disorders: 85

Migraine Disorders: 6458

Migraine with Aura: 394

Related Diseases

1.	Headache (Headaches)
2.	Migraine Disorders (Migraine)
3.	Migraine without Aura (Common Migraine)
4.	Epilepsy (Aura)
5.	Pain (Aches)

Experts

1.	van den Maagdenberg, Arn M J M: 7 articles (07/2008 - 09/2003)
2.	Ferrari, Michel D: 5 articles (07/2008 - 09/2003)
3.	Frants, R R: 3 articles (01/2008 - 06/2001)
4.	Vanmolkot, Kaate R J: 3 articles (08/2007 - 09/2003)
5.	Frants, Rune R: 3 articles (08/2007 - 09/2003)
6.	Haan, Joost: 3 articles (08/2007 - 09/2003)
7.	Koenderink, Jan B: 3 articles (08/2007 - 05/2005)
8.	Dichgans, Martin: 2 articles (07/2008 - 07/2005)
9.	Freilinger, Tobias: 2 articles (07/2008 - 07/2005)
10.	Pusch, Michael: 2 articles (07/2008 - 07/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Migraine with Aura:

1.	FlunarizineIBA 01/01/1989 - "Flunarizine i.v. in the acute treatment of common or classical migraine attacks--a placebo-controlled double blind trial." 05/01/1985 - "This was supported by a study in twenty patients with classical migraine who were, after a drug-free running-in phase, orally treated with either placebo or flunarizine (10 mg at night) for three to four months" 03/01/1985 - "This was supported by a study in 20 patients with classical migraine who were, after a drug free run-in phase, orally treated with either placebo or flunarizine (10 mg at night) for 3 to 4 months" 11/01/1992 - "Severe case of basilar migraine treated with flunarizine]" 01/01/1986 - "Effect of flunarizine on regional cerebral blood flow in common and complicated migraine" Order ALL the reference details at left...
2.	Verapamil (Calan)FDA LinkGeneric 02/01/2006 - "Treatment for presumptive migraine with aura with verapamil nearly eradicated symptoms in both patients" 11/13/2001 - "Familial hemiplegic migraine and its abortive therapy with intravenous verapamil." 09/01/1992 - "Intravenous verapamil in acute migraine with prolonged aura." 11/01/2006 - "Oral verapamil is recommended for patients with familial hemiplegic migraine and may be effective in patients with sporadic hemiplegic migraine" 12/01/2004 - "The present review deals with recent scientific studies according to which: The SHM prevalence is estimated to be 0.005%; SHM patients have clinical symptoms identical to patients with familial hemiplegic migraine (FHM) and significantly different from patients with migraine with typical aura (typical MA); SHM affected had no increased risk of migraine without aura (MO), but a highly increased risk of typical MA compared to the general population; SHM patients only rarely have mutations in the FHM gene CACNA1A; SHM attacks in some cases can be treated with Verapamil" Order ALL the reference details at left...
3.	Ion Channels (Ion Channel)IBA 04/01/2005 - "Genetic studies have begun to provide plausible targets for the basic molecular defect in terms of ion channels, albeit thus far in the rare condition of familial hemiplegic migraine (FHM)" 06/01/2004 - "Studies of gene associations, neuromuscular transmission, cerebellar functions, neuronal excitability and metabolism and certain drug effects suggest indeed that ionic channels play a pathogenic role in migraine with aura patients" 05/01/2008 - "Finally, the three identified ion-channel genes that can cause familial hemiplegic migraine provide very strong evidence of genetics" 10/01/2001 - "Familial hemiplegic migraine: a ion channel disorder." 02/01/2007 - "In this review we discuss results of genetic studies to date, from the discovery of the role of neural ion channel gene mutations in familial hemiplegic migraine (FHM) to linkage analyses and candidate gene studies in the more common forms of migraine" Order ALL the reference details at left...
4.	zolmitriptan (Zomig)FDA Link 07/01/2002 - "Zolmitriptan is effective in the treatment of migraine associated with menses and migraine with aura" 08/01/1999 - "Zolmitriptan is effective in the treatment of migraine associated with menses and migraine with aura" Order ALL the reference details at left...
5.	Propranolol (Inderal)FDA LinkGeneric 04/01/1987 - "Children aged 6 to 12 years with classic migraine who had no previous specific treatment were randomized into propranolol (at 3 mg/kg/d) or placebo groups for a 3-month period and then crossed over for 3 months" 03/01/1982 - "An occurrence of complicated migraine during propranolol therapy." 01/01/1981 - "Basilar artery migraine in a child: excellent response to propranolol." 03/01/1980 - "Considerations on the use of propranolol in complicated migraine." 04/01/1987 - "In a prospective study we compared propranolol, placebo, and self-hypnosis in the treatment of juvenile classic migraine" Order ALL the reference details at left...
6.	SodiumIBA 06/01/2004 - "Studies on the genetics of familial hemiplegic migraine revealed, in addition to the previously identified familial hemiplegic migraine type 1 gene CACNA1A on chromosome 19, the familial hemiplegic migraine type 2 gene ATP1A2, encoding the alpha2-subunit of sodium/potassium pumps" 03/01/1985 - "Naproxen sodium proved safe and effective in common migraine attacks, but in this study efficacy was not established for classical migraine." 07/01/2007 - "The best evidence to date comes from certain subtypes of migraine with aura in which point mutations in genes controlling translocation of calcium, sodium and potassium have been implicated" 06/01/2006 - "Mutations associated with familial hemiplegic migraine render the brain more susceptible to prolonged cortical spreading depression caused by either excessive synaptic glutamate release or decreased removal of glutamate and potassium from the synaptic cleft, or persistent sodium influx" 07/01/2006 - "BACKGROUND: Pharmaceuticals with calcium- or sodium-channel-blocking activity have proven useful for migraine prophylaxis, and calcium channel, sodium transporter, and sodium channel gene mutations have been found in familial hemiplegic migraine" Order ALL the reference details at left...
7.	Metoprolol (Lopressor)FDA LinkGeneric 12/01/1988 - "The present study is a placebo-controlled, double-blind study concerning metoprolol in classic migraine" 12/01/1988 - "Symptoms of classic migraine attacks: modifications brought about by metoprolol." 12/01/1987 - "Metoprolol is the first drug for which a prophylactic effect in classic migraine has been convincingly demonstrated." 12/01/1987 - "Classic migraine: effective prophylaxis with metoprolol." 12/01/1983 - "Prophylactic treatment of classical and non-classical migraine with metoprolol--a comparison with placebo." Order ALL the reference details at left...
8.	lamotrigine (Lamictal)FDA LinkGeneric 01/01/1999 - "We report a small open pilot study to evaluate the efficacy of lamotrigine (100 mg/day) in the prevention of migraine with aura attacks" 12/01/2005 - "Fifty nine patients suffering from migraine with aura received lamotrigine in a controlled three year prospective open study" 01/01/1999 - "Lamotrigine seems worthy of a controlled trial as prophylaxis of a migraine with aura." 05/01/2007 - "Basilar-type migraine responsive to lamotrigine: three case reports." 01/01/1999 - "Effectiveness of lamotrigine in the prophylaxis of migraine with aura: an open pilot study." Order ALL the reference details at left...
9.	Acetazolamide (Diamox)FDA LinkGeneric 04/01/2005 - "Acetazolamide efficacy and tolerability in migraine with aura: a pilot study." 11/01/1996 - "Acetazolamide responsiveness in familial hemiplegic migraine." 04/01/2005 - "The study was an open uncontrolled pilot trial to test the efficacy and the tolerability of acetazolamide in a group of 22 outpatients suffering from migraine with aura (MA) with at least one aura episode in the last 2 months." 12/11/2001 - "Acetazolamide for the treatment of migraine with aura in CADASIL." 07/13/1999 - "A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia." Order ALL the reference details at left...
10.	MagnesiumIBA 06/01/2002 - "In the migraine with aura group patients receiving magnesium sulphate presented a statistically significant improvement of pain and of all associated symptoms compared with controls" 06/01/2002 - "Our data support the idea that magnesium sulphate can be used for the treatment of all symptoms in migraine with aura, or as an adjuvant therapy for associated symptoms in patients with migraine without aura." 06/01/2002 - "Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura" 06/01/2002 - "This randomized, double-blind, placebo-controlled study assesses the effect of magnesium sulphate on the pain and associated symptoms in patients with migraine without aura and migraine with aura" 02/01/1994 - "Intracellular and plasma magnesium in familial hemiplegic migraine and migraine with and without aura." Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 03/01/2005 - "Recurrence of migraine with aura due to tacrolimus therapy in a liver transplant recipient successfully treated with sirolimus substitution." 03/01/2005 - "We report the case of a female liver transplant recipient who developed a recurrence of severe migraine with aura while on tacrolimus therapy with subsequent remission of headache following discontinuation of tacrolimus and substitution with sirolimus therapy" Order ALL the reference details at left...
2.	Resuscitation 01/01/1985 - "Clinical trials utilizing Mg as a therapeutic tool to treat refractory arrhythmias, digitalis toxicity-associated arrhythmias, myocardial infarctions, diabetic angiopathy, transient ischemic attacks, cerebral resuscitation, hypertension and 'classical' migraine are under way, and to an extent have been successful" Order ALL the reference details at left...
3.	Ambulatory Care (Outpatient Care) 08/01/2006 - "RESULTS: Of 423 patients reporting tension/stress headache at study entry, 84% (n = 357) were diagnosed at the clinic visit as fulfilling IHS criteria for migraine without aura or migraine with aura, and 65% (n = 276) were diagnosed with migraine only (i.e., with no other concurrent headache diagnosis)" Order ALL the reference details at left...
4.	Contraception (Birth Control) 01/01/1998 - "Women with classic migraine should avoid OCs if an alternative method of contraception can be used" 12/01/1978 - "Clinical observations suggest that a casual relationship exists between the increased platelet aggregability and complicated migraine attacks which appear during the course of oral contraception" 09/01/2000 - "Migraine as a risk factor in relation to cardiovascular disease remains a subject of discussion, and migraine with aura appears to present a cerebral infarct risk in young women taking oral contraception" 01/01/2008 - "That migraine may be sex-influenced (autosomal dominant in females and autosomal recessive in males) is supported by such evidences as: (1) familial hemiplegic migraine, subtype from migraine with aura, being dominantly assigned to autosomal chromosome 19p, 1q, and 2q; (2) a male to female prevalence of 1:2-4; (3) primarily young age of onset; (4) provocation by pharmaceutical contraception; (5) induction by menstruation; (6) self-limitation after menopause; and (7) only female migraineurs in some migraine families" Order ALL the reference details at left...
5.	Decompression 02/01/2001 - "While conducting research in divers with decompression illness, it was our impression that divers with a large shunt often had a history of migraine with aura in everyday life and after dives" 04/01/2006 - "Pulmonary hypertension and entities like decompression illness, migraine with aura or plathypnea-orthodeoxia have been found to have a higher prevalence of PFO with RLSh" Order ALL the reference details at left...

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