Nervous System Mercury Poisoning (Minamata Disease)

Neurologic disorders associated with exposure to inorganic and organic forms of MERCURY. Acute intoxication may be associated with gastrointestinal disturbances, mental status changes, and PARAPARESIS. Chronic exposure to inorganic mercury usually occurs in industrial workers, and manifests as mental confusion, prominent behavioral changes (including psychosis), DYSKINESIAS, and NEURITIS. Alkyl mercury poisoning may occur through ingestion of contaminated seafood or grain, and its characteristic features include POLYNEUROPATHY; ATAXIA; vision loss; NYSTAGMUS, PATHOLOGIC; and DEAFNESS. (From Joynt, Clinical Neurology, 1997, Ch20, pp10-15)
Also Known As:
Minamata Disease; Mercury Poisoning, Nervous System; Encephalopathy, Mercury; Inorganic Mercury Poisoning; Mad Hatter Disease; Mad Hatter's Disease; Mercurial Neuroanesthenia; Mercurial Psychosis; Mercury Poisoning, Inorganic; Mercury Poisoning, Neurologic; Mercury Poisoning, Organic; Mercury Psychosis; Organic Mercury Poisoning; Mad Hatter Diseases; Mad Hatters Disease; Mercury Induced Nervous System Diseases; Mercury Neurotoxicity Syndrome; Mercury Neurotoxicity Syndromes; Nervous System Diseases, Mercury Induced; Nervous System Mercurialism; Neuroanesthenia, Mercurial; Neurologic Mercurialism; Neurologic Mercury Poisoning; Neurotoxicity Syndromes, Mercury; Poisoning, Inorganic Mercury; Poisoning, Neurologic Mercury; Poisoning, Organic Mercury; Psychosis, Mercurial; Psychosis, Mercury; Syndrome, Mercury Neurotoxicity; Syndromes, Mercury Neurotoxicity; System Mercurialism, Nervous; Mercurialism, Nervous System; Mercurialism, Neurologic; Mercury Encephalopathy; Mercury-Induced Nervous System Diseases; Nervous System Diseases, Mercury-Induced; Nervous System Poisoning, Mercury; Neurotoxicity Syndrome, Mercury; Poisoning, Mercury, Nervous System; Poisoning, Mercury, Neurologic
Networked: 90 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Poisoning
2. Communication Disorders (Communication Disorder)
3. Nervous System Mercury Poisoning (Minamata Disease)
4. Tremor (Tremors)
5. Neoplasms (Cancer)


1. Ishihara, Nobuo: 3 articles (01/2014 - 01/2002)
2. Akagi, H: 3 articles (08/2001 - 08/2000)
3. Sakamoto, Mineshi: 2 articles (05/2007 - 07/2006)
4. Kizaki, T: 2 articles (10/2001 - 03/2001)
5. Harada, M: 2 articles (10/2001 - 03/2001)
6. Ohno, H: 2 articles (10/2001 - 03/2001)
7. Takeda, Masayuki: 1 article (06/2013)
8. Takahashi, Kota: 1 article (06/2013)
9. Saito, Hisashi: 1 article (06/2013)
10. Hara, Noboru: 1 article (06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nervous System Mercury Poisoning:
1. SulfurIBA
2. Succimer (Dimercaptosuccinic Acid)FDA Link
3. MercuryIBA
4. Mercury CompoundsIBA
5. AcetaldehydeIBA
6. AntigensIBA
7. AntibodiesIBA
8. Industrial Waste (Industrial Wastes)IBA
9. Heavy MetalsIBA
10. Unithiol (DMPS)IBA

Therapies and Procedures

1. Activities of Daily Living (ADL)
2. Chelation Therapy (Therapy, Chelation)
3. Renal Dialysis (Hemodialysis)
4. Oral Administration