Optic Nerve Injuries

Injuries to the optic nerve induced by a trauma to the face or head. These may occur with closed or penetrating injuries. Relatively minor compression of the superior aspect of orbit may also result in trauma to the optic nerve. Clinical manifestations may include visual loss, PAPILLEDEMA, and an afferent pupillary defect.
Also Known As:
Cranial Nerve II Injuries; Optic Nerve Avulsion; Optic Nerve Contusion; Optic Nerve Transection; Second Cranial Nerve Injuries; Trauma, Second Cranial Nerve; Avulsion, Optic Nerve; Avulsions, Optic Nerve; Contusion, Optic Nerve; Contusions, Optic Nerve; Injuries, Optic Nerve; Injury, Optic Nerve; Nerve Avulsion, Optic; Nerve Avulsions, Optic; Nerve Contusion, Optic; Nerve Contusions, Optic; Nerve Injuries, Optic; Nerve Injury, Optic; Nerve Transection, Optic; Nerve Transections, Optic; Nerve Trauma, Optic; Nerve Traumas, Optic; Neuropathies, Traumatic Optic; Neuropathy, Traumatic Optic; Optic Nerve Avulsions; Optic Nerve Contusions; Optic Nerve Injury; Optic Nerve Transections; Optic Nerve Traumas; Optic Neuropathies, Traumatic; Transection, Optic Nerve; Transections, Optic Nerve; Trauma, Optic Nerve; Traumas, Optic Nerve; Traumatic Optic Neuropathies; Traumatic Optic Neuropathy; Optic Nerve Trauma; Optic Neuropathy, Traumatic; Second Cranial Nerve Trauma
Networked: 543 relevant articles (34 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Retinal Degeneration
2. Ischemia
3. Spinal Cord Injuries (Spinal Cord Injury)
4. Blindness (Hysterical Blindness)
5. Ganglion Cysts (Ganglion)


1. Kato, Satoru: 17 articles (01/2016 - 09/2004)
2. Koriyama, Yoshiki: 14 articles (01/2016 - 09/2004)
3. Sugitani, Kayo: 10 articles (01/2016 - 09/2004)
4. Vidal-Sanz, Manuel: 9 articles (07/2015 - 06/2004)
5. Ogai, Kazuhiro: 6 articles (01/2016 - 12/2012)
6. So, Kwok-Fai: 6 articles (01/2015 - 12/2004)
7. Mawatari, Kazuhiro: 6 articles (01/2014 - 09/2004)
8. Berry, Martin: 6 articles (11/2013 - 10/2005)
9. Quigley, Harry A: 6 articles (03/2013 - 07/2002)
10. Cui, Qi: 6 articles (01/2013 - 04/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Optic Nerve Injuries:
1. MethylprednisoloneFDA LinkGeneric
2. Ciliary Neurotrophic Factor (CNTF)IBA
3. Caspase 3 (Caspase-3)IBA
4. Dexamethasone (Maxidex)FDA LinkGeneric
5. benzoylcarbonyl- aspartyl- glutamyl- valyl- aspartyl- fluoromethyl ketoneIBA
6. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
7. ErythropoietinFDA Link
8. Kainic Acid (Kainate)IBA
9. Brain-Derived Neurotrophic Factor (BDNF)IBA
10. Mannitol (Osmitrol)FDA LinkGeneric

Therapies and Procedures

1. Decompression
2. Transplantation (Transplant Recipients)
3. Intravitreal Injections
4. Surgical Decompression
5. Axotomy