Sleep Bruxism

A sleep disorder characterized by grinding and clenching of the teeth and forceful lateral or protrusive jaw movements. Sleep bruxism may be associated with TOOTH INJURIES; TEMPOROMANDIBULAR JOINT DISORDERS; sleep disturbances; and other conditions.

Also Known As:

Sleep Bruxism, Adult; Sleep Bruxism, Childhood; Sleep-Related Bruxism; Teeth Grinding Disorder, Nocturnal; Adult Sleep Bruxism; Adult Sleep Bruxisms; Bruxism, Sleep; Bruxism, Sleep-Related; Bruxisms, Nocturnal; Bruxisms, Sleep; Bruxisms, Sleep-Related; Childhood Sleep Bruxism; Childhood Sleep Bruxisms; Nocturnal Bruxism; Nocturnal Bruxisms; Sleep Bruxisms; Sleep Bruxisms, Adult; Sleep Bruxisms, Childhood; Sleep Related Bruxism; Sleep-Related Bruxisms; Bruxism, Nocturnal; Nocturnal Teeth Grinding Disorder

Networked: 284 relevant articles (39 outcomes, 106 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Bruxism
3.	Temporomandibular Joint Disorders (Temporomandibular Joint Disorder)
4.	Bites and Stings (Sting)
5.	Sleep Apnea Syndromes (Sleep Apnea)

Experts

1.	Martynowicz, Helena: 9 articles (04/2022 - 08/2019)
2.	Mazur, Grzegorz: 9 articles (04/2022 - 08/2019)
3.	Lavigne, Gilles J: 9 articles (01/2020 - 03/2006)
4.	Smardz, Joanna: 8 articles (04/2022 - 08/2019)
5.	Wieckiewicz, Mieszko: 8 articles (04/2022 - 08/2019)
6.	Wojakowska, Anna: 8 articles (04/2022 - 08/2019)
7.	Bussadori, Sandra Kalil: 7 articles (01/2021 - 10/2013)
8.	Castelo, Paula Midori: 7 articles (01/2021 - 06/2012)
9.	Lobbezoo, Frank: 6 articles (11/2022 - 01/2005)
10.	Baba, Kazuyoshi: 6 articles (01/2022 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sleep Bruxism:

1.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2010 - "Our controlled study supports the use of botulinum toxin injection as an effective treatment for nocturnal bruxism." 12/01/2022 - "Introduction Botulinum toxin (Botox®) is considered an effective treatment for nocturnal bruxism when injected into the masseter muscle. " 12/01/2022 - "Evaluation of the Efficacy of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle for the Treatment of Nocturnal Bruxism: A Randomized Controlled Clinical Trial." 01/01/2018 - "The risk of bias of the RCTs was assessed as low to unclear, while the before and after studies were assessed as of moderate risk of bias.ConclusionsThe authors concluded that botulinum toxin represents a possible option for the management of sleep bruxism (SB), minimising symptoms and reducing the intensity of contractions rather than for SB itself." 01/01/2017 - "The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism."
2.	Type A Botulinum Toxins (Botox)FDA Link 01/01/2017 - "The aim of this study was to evaluate the efficacy of botulinum toxin A (BTXA) in the treatment of nocturnal bruxism. " 01/01/2022 - "Efficacy of botulinum toxin type a in the targeted treatment of sleep bruxism: a double-blind, randomised, placebo-controlled, cross-over study." 01/01/2010 - "To evaluate the effect of botulinum toxin type A on nocturnal bruxism. " 01/01/2022 - "Intramuscular injections of botulinum toxin A (BTX-A) have been used in the treatment of sleep bruxism (SB) however controlled trials are limited and the optimal injection strategy and dose is not known. " 12/01/2021 - "This randomized, single-blinded, control-group, pretest-posttest prospective trial evaluated the occlusal guard and Botox injections (BTX) effectiveness in managing sleep bruxism (SB) in subjects whose one of the edentulous arches had been restored with the implant-supported OD. "
3.	Clonazepam (Rivotril)FDA LinkGeneric 02/01/2016 - "In patients with psychiatric and sleep comorbidities, the acute use of clonazepam at night has been reported to improve sleep bruxism, but in the absence of double-blind randomized trials, its use in general clinical practice cannot be recommended. " 01/01/2005 - "On the pharmacotherapy of sleep bruxism: placebo-controlled polysomnographic and psychometric studies with clonazepam." 01/01/2023 - "The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. " 01/01/2017 - "In young adults with primary sleep bruxism, clonidine was significantly more effective in suppressing sleep bruxism than clonazepam. " 01/01/2017 - "The aim of this study was to assess the acute effects of clonazepam and clonidine on rhythmic masticatory muscle activity in young adults with primary sleep bruxism, as well as accompanying effects on sleep architecture and cardiac activity. "
4.	Clonidine (ST 155)FDA LinkGeneric 12/01/2010 - "Clonidine disrupts the NREM/REM sleep cycle and reduces the incidence of rhythmic masticatory muscle activity (RMMA) characteristic of sleep bruxism (SB). " 12/01/2010 - "Clonidine has a paradoxical effect on cyclic arousal and sleep bruxism during NREM sleep." 03/01/2006 - "Under clonidine, a reduction in heart rate and sympathetic dominance was observed in stable sleep and in the minute preceding the onset of sleep bruxism (p < .05). " 03/01/2006 - "Under clonidine, duration of sleep stage 2 was prolonged, whereas REM sleep was suppressed in 14 of 16 subjects with sleep bruxism. " 10/01/2007 - "Taking into account the NNT, the effect size and the power of each study, it can be concluded that the following treatments reduce sleep bruxism: mandibular advancement device, clonidine and occlusal splint. "
5.	incobotulinumtoxinA FDA Link 01/01/2018 - "BoNT-A effectively and safely improved sleep bruxism in this placebo-controlled pilot trial. " 04/01/2017 - "Despite the paucity of works on the topic, BoNT-A seems to be a possible management option for sleep bruxism, minimizing symptoms and reducing the intensity of muscle contractions, although further studies are necessary especially as far as the treatment indications for bruxism itself is concerned. " 01/01/2020 - "The purpose of this study is to evaluate the effects of botulinum toxin type A (BoNT-A) for managing sleep bruxism (SB) in a randomized, placebo-controlled trial. " 01/01/2018 - "To test the safety and efficacy of onabotulinum toxin-A (BoNT-A) injections into the masseter and temporalis muscles in patients with symptomatic sleep bruxism. " 09/06/2021 - "To evaluate the effects of low doses of botulinum toxin type A (BoNT-A) to control pain in patients with sleep bruxism (SB), awake bruxism (AB), and temporomandibular disorder (TMD) during 180 days. "
6.	Buspirone (Buspar)FDA LinkGeneric 11/01/2021 - "In this small series of cases, buspirone proved effective in the control of nonpharmacological awake and sleep bruxism." 11/01/2021 - "The aim of the study was to describe the efficacy of buspirone in controlling nonpharmacological awake and sleep bruxism. " 07/01/2019 - "We present a 7-year-old boy whose sleep bruxism symptoms disappeared with a single daily dose of buspirone treatment in this report." 07/01/2019 - "Treatment of Sleep Bruxism With a Single Daily Dose of Buspirone in a 7-Year-Old Boy." 11/01/1993 - "In addition, they suggest that a decrease in SSRI dosage or the addition of buspirone may relieve SSRI-associated nocturnal bruxism."
7.	Dopamine Agonists (Dopamine Agonist)IBA 05/01/2022 - "Various factors are responsible for sleep bruxism; however, whether the dopaminergic agonist group of drugs is effective in the treatment of sleep bruxism is unclear. " 05/01/2022 - "Clinical trials using the dopaminergic agonist group of drugs as a treatment approach to sleep bruxism were included. " 05/01/2022 - "The purpose of this systematic review was to evaluate the effect of the dopaminergic agonist group of drugs in controlling sleep bruxism in comparison with no treatment or placebo-controlled treatment. " 05/01/2022 - "Effect of dopaminergic agonist group of drugs in treatment of sleep bruxism: A systematic review." 01/01/2021 - "Response to the letter to the editor regarding "Concerns regarding the published article 'Effect of dopaminergic agonist group of drugs in treatment of sleep bruxism: A systematic review' by Bhattacharjee et al. "
8.	Gabapentin (Neurontin)FDA LinkGeneric 02/01/2013 - "The efficacy of gabapentin versus stabilization splint in management of sleep bruxism." 02/01/2013 - "This study aimed to determine if the use of gabapentin is more efficacious than a stabilization splint with regard to the intensity of masseter muscle contractions and/or sleep quality for patients experiencing sleep bruxism (SB). " 11/01/2014 - "Nocturnal bruxism in a patient with Behçet disease and posttraumatic stress disorder successfully treated with gabapentin."
9.	ElementsIBA 01/01/2008 - "The object of this study was to determine if anterior bite stop appliances with a small discluding element would be helpful in managing the subject's nocturnal bruxism symptoms."
10.	onabotulinum toxin AIBA 01/01/2018 - "Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study." 01/01/2018 - "To test the safety and efficacy of onabotulinum toxin-A (BoNT-A) injections into the masseter and temporalis muscles in patients with symptomatic sleep bruxism. "

Therapies and Procedures

1.	Occlusal Splints 04/01/2014 - "The occlusal splint has been used for many years as an effective treatment of sleep bruxism. " 10/01/2013 - "The use of an occlusal splint was effective in reducing the symptoms of sleep bruxism and other sleep problems. " 01/01/2008 - "There is not enough evidence to state that the occlusal splint is effective for treating sleep bruxism. " 10/17/2007 - "There is not sufficient evidence to state that the occlusal splint is effective for treating sleep bruxism. " 06/27/2022 - "The gold standard for the management of sleep bruxism (SB) is the use of a rigid occlusal splint; however, there are limitations for its use in children and alternatives to the management of SB are needed. "
2.	Therapeutics 04/01/2023 - "The aim of the study was to evaluate the methodological quality and the risk of bias of systematic reviews with regard to the literature on therapies for sleep bruxism (SB) in dentistry, applying the AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews) qualitative guide, as well as the effectiveness of various kinds of treatment of SB. " 03/01/2016 - "The aim of the present study was to evaluate electromyographic signals in the temporal muscle using the BiteStrip(®) test on children with sleep bruxism before and after therapy with Melissa officinalis L. " 01/01/2015 - "However, clinical findings suggest that further studies are needed to clarify sleep bruxism pathophysiology and to develop new approaches to tailor therapy for individual patients with concomitant sleep bruxism and OSA. " 10/01/2007 - "To determine the best current treatment, 2 measures were used to compare the results of 10 clinical studies on sleep bruxism, 3 involving oral devices and 7 involving pharmacologic therapy. " 10/01/1989 - "On the basis of original studies of the interdisciplinary type (prosthetic gnathology and neurophysiology), with the aid of polygraphic investigations during sleep carried out in subjects with nocturnal bruxism it was possible to demonstrate that this oral parafunction may determine sleep disturbances at a central level which makes necessary a complex stomatologic and neuropsychiatric medical therapy."
3.	Splints (Splint) 01/01/2005 - "To assess the efficacy of occlusal stabilization splints in the management of sleep bruxism (SB) in a double-blind, parallel, controlled, randomized clinical trial. " 01/01/2005 - "Controlled assessment of the efficacy of occlusal stabilization splints on sleep bruxism." 04/01/2015 - "The obtained results of the present exploratory trial indicate that the intermittent use of stabilisation splints may reduce sleep bruxism activity for a longer period compared with that of continuous use. " 01/01/2013 - "The aim of this study was to observe the mandibular response during sleep bruxism (SB) on the elimination of occlusal influences by using a flat anterior and lateral guidance splint (FGS). " 02/01/2012 - "To study the short-term effects of nociceptive trigeminal inhibitory tension suppression system (NTI-tss) and occlusal stabilization splint (OS) on sleep bruxism patients. "
4.	Psychology Biofeedback (Biofeedback) 01/01/2022 - "This study aims to test a customised device for detecting contact-related sleep bruxism in adult patients and to show the efficacy of an established biofeedback method incorporated within the device. " 05/01/2014 - "The aim of this systematic review was to evaluate the efficacy of any biofeedback treatment on sleep bruxism. " 05/01/2014 - "We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, ISI Web of Science, System for Information on Grey Literature in Europe, Chinese Biomedical Literature Database, and PsycINFO up to October 2012 for randomized controlled trials and controlled clinical trials involving biofeedback treatment for sleep bruxism. " 12/01/1982 - "The present study was conducted to provide a more rigorous evaluation of the effectiveness of nocturnal biofeedback for nocturnal bruxism through the use of all-night polysomnographic recordings. " 01/01/2022 - "Various biofeedback stimulation techniques of managing sleep bruxism (SB) have recently emerged; however, the effect of successive application of vibratory feedback stimulation has not been clarified. "
5.	Injections 01/01/2018 - "This study provides Class II evidence that botulinum injections into the masseter and temporalis muscles improve subjective bruxism and painful symptoms associated with sleep bruxism." 12/01/2021 - "This randomized, single-blinded, control-group, pretest-posttest prospective trial evaluated the occlusal guard and Botox injections (BTX) effectiveness in managing sleep bruxism (SB) in subjects whose one of the edentulous arches had been restored with the implant-supported OD. " 01/01/2018 - "Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study." 12/01/2022 - "The objective was to determine whether 10 MU of botulinum toxin type A (BTXA) injections into the masseter muscle could lessen nocturnal bruxism. " 07/14/2021 - "To determine the efficacy of injectable botulinum toxin (BTA) in the management of pain associated with nocturnal bruxism. "