|2.||Hypertension (High Blood Pressure)
|4.||Weight Loss (Weight Reduction)
|1.||Gozal, David: 40 articles (10/2015 - 02/2002)|
|2.||Malhotra, Atul: 26 articles (08/2015 - 03/2003)|
|3.||Tufik, Sergio: 25 articles (09/2015 - 05/2006)|
|4.||Guilleminault, Christian: 24 articles (08/2015 - 01/2002)|
|5.||Kheirandish-Gozal, Leila: 23 articles (09/2015 - 07/2006)|
|6.||Somers, Virend K: 23 articles (12/2014 - 05/2002)|
|7.||Cistulli, Peter A: 21 articles (09/2015 - 09/2002)|
|8.||Grunstein, Ronald R: 20 articles (12/2015 - 04/2002)|
|9.||White, David P: 19 articles (09/2015 - 03/2003)|
|10.||Dimsdale, Joel E: 18 articles (01/2014 - 12/2002)|
09/01/2001 - "Subjective symptoms of obstructive sleep apnea improved, and the ESS score significantly decreased after a 30-night treatment with oxygen. "
01/01/2013 - "The objective of this study is to determine whether obstructive sleep apnea (OSA) is associated with reduced fetal growth, and whether nocturnal oxygen desaturation precipitates acute fetal heart rate changes. "
03/01/2011 - "The aim of the study was to investigate effects of shift work on obstructive sleep apnea syndrome (OSAS) and oxygen desaturation index (ODI) during daytime and nighttime sleep in patients with OSAS. "
12/01/2010 - "This study focuses on the analysis of blood oxygen saturation (SaO(2)) from nocturnal pulse oximetry (NPO) to help in the diagnosis of the obstructive sleep apnea (OSA) syndrome. "
01/01/2009 - "This study assessed the hypothesis that blood oxygen saturation (SaO(2)) and electroencephalogram (EEG) recordings could provide complementary information in the diagnosis of the obstructive sleep apnea (OSA) syndrome. "
|2.||modafinil (armodafinil)FDA Link
02/15/2014 - "Double-Blind, Placebo-Controlled, Functional Neuroimaging Study of Armodafinil (200 mg/Day) on Prefrontal Cortical Activation in Patients With Residual Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea."
01/01/2010 - "A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression."
02/15/2008 - "Previous studies have evaluated the effect of modafinil on residual excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS) under effective CPAP treatment. "
05/01/2006 - "Effects of armodafinil in the treatment of residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome: a 12-week, multicenter, double-blind, randomized, placebo-controlled study in nCPAP-adherent adults."
04/01/2005 - "These results confirm previous shorter-term controlled trials, indicating modafinil is a useful adjunct therapy for improving wakefulness in patients with residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome who were treated with nCPAP."
|3.||Acetaminophen (Paracetamol)FDA LinkGeneric
01/01/2007 - "Automatic pressure titration with APAP is as effective as manual titration with CPAP in patients with obstructive sleep apnea."
09/01/2015 - "This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. "
01/01/2015 - "Study of a Novel APAP Algorithm for the Treatment of Obstructive Sleep Apnea in Women."
09/01/2013 - "Effectiveness of a group education session on adherence with APAP in obstructive sleep apnea--a randomized controlled study."
08/15/2008 - "To describe our clinical experience with autoadjusting positive airway pressure (APAP) trials carried out on patients with moderate-to-severe obstructive sleep apnea (OSA). "
08/01/2004 - "In recent years a number of randomized controlled trials suggests secondary endpoints such as symptoms, sympatho-excitation and left ventricular function can be improved with the effective therapies available for both central and obstructive sleep apnea in patients in which these conditions co-exist. "
06/01/2001 - "This study was designed to examine respiratory control in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), with or without CO(2) retention. "
06/01/2014 - "To investigate the common indications for polysomnogram (PSG) associated co-morbid conditions, evaluation strategies, treatment options, and outcomes in a series of infants diagnosed with obstructive sleep apnea (OSA) by a PSG. "
01/01/2014 - "Comparison of cardiovascular co-morbidities and CPAP use in patients with positional and non-positional mild obstructive sleep apnea."
01/01/2014 - "The French version was validated using a sample of 150 patients treated for obstructive sleep apnea syndrome (OSAS) and having multiple chronic co-morbidities. "
|5.||Insulin (Novolin)FDA Link
04/01/2015 - "The aim of this study was to assess insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) concentrations in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to compare the results according to disease severity and duration. "
08/01/2015 - "In treated patients with diabetes, HbA1c was associated with non-sleep variables, including age, metabolic dyslipidaemia and insulin use, but not with obstructive sleep apnea severity. "
04/01/2015 - "Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 concentrations in children with obstructive sleep apnea-hypopnea syndrome."
04/01/2015 - "Obstructive sleep apnea (OSA) has been recognized as being associated with low level of insulin growth factor-1 (IGF-1). "
08/01/2013 - "M-value and acute insulin response increased significantly only in patients without obstructive sleep apnea (990.10 ± 170.19 vs. 1,205.22 ± 145.73 μmol min(-1) m(-2), p = 0.046; -1.05 ± 8.40 vs. 48.26 ± 11. "
|6.||salicylhydroxamic acid (SHAM)IBA
08/01/2008 - "In patients with only obstructive sleep apnea (OSA), who account for 83% of the total population, there was a significant improvement in the LVEF in the group of patients treated with CPAP but no such improvement in the sham-CPAP group. "
12/15/2011 - "In our double-blind, placebo-controlled trial, we randomly assigned patients with obstructive sleep apnea syndrome to undergo 3 months of therapeutic CPAP followed by 3 months of sham CPAP, or vice versa, with a washout period of 1 month in between. "
04/01/2011 - "Trial name: Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea (AERO). "
04/01/2011 - "19 sites including both academic and private sleep disorder centers Obstructive sleep apnea with a pre-study AHI ≥10/hour Treatment with a nasal EPAP device (N=127) or similar appearing sham device (N=123) for 3 months. "
02/01/2010 - "The results support the use of sham-CPAP as a placebo intervention in trials evaluating the effects of CPAP treatment in patients with obstructive sleep apnea. "
06/20/2013 - "We hypothesized that, in children with the obstructive sleep apnea syndrome without prolonged oxyhemoglobin desaturation, early adenotonsillectomy, as compared with watchful waiting with supportive care, would result in improved outcomes. "
01/01/2009 - "To comprehensively evaluate the ability and reliability of the representative previously proposed oxyhemoglobin indexes derived automatically for predicting the severity of obstructive sleep apnea hypopnea syndrome (OSAHS). "
01/01/2009 - "Comparison of the indices of oxyhemoglobin saturation by pulse oximetry in obstructive sleep apnea hypopnea syndrome."
05/01/2005 - "Obstructive sleep apnea and hypopnea syndrome (OSAHS) are characterized by repeated pauses in breathing during sleep, usually associated with sleep interruption and decreased oxyhemoglobin saturation. "
06/01/2003 - "Obstructive sleep apnea (OSA) refers to the occurrence of episodes of complete or partial pharyngeal obstruction with oxyhemoglobin desaturation during sleep. "
|8.||Acetazolamide (Diamox)FDA LinkGeneric
10/01/1998 - "Interaction with chemical drives (eg by administration of acetazolamide) has been shown to improve central (and eventually also obstructive) sleep apnea. "
01/01/2012 - "Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial."
01/01/2014 - "Impact of acetazolamide and CPAP on cortical activity in obstructive sleep apnea patients."
02/01/2013 - "Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea."
12/12/2012 - "Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial."
|9.||sildenafil (Viagra)FDA Link
06/01/2010 - "To evaluate the magnitude of effects of sildenafil on respiratory parameters and heart rate variability (HRV) in slow wave sleep (SWS) and REM sleep of patients with severe obstructive sleep apnea (OSA). "
06/01/2010 - "The effect of sildenafil on sleep respiratory parameters and heart rate variability in obstructive sleep apnea."
04/01/2010 - "Thirteen male patients with severe obstructive sleep apnea (mean age 43+/-10 years with a mean body mass index of 26.7+/-1.9 kg/m(2)) received a single 50-mg dose of sildenafil or a placebo at bedtime. "
04/01/2010 - "To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. "
04/01/2010 - "Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea."
01/01/2009 - "Nasal steroids helpful for short-term treatment of children with obstructive sleep apnea."
06/01/2012 - "Excess endogenous steroids are a risk factor for obstructive sleep apnea (OSA). "
07/01/2008 - "These findings justify the use of topical steroids as the initial therapeutic option in otherwise healthy children with mild obstructive sleep apnea."
06/01/2001 - "Nasal steroids as treatment for obstructive sleep apnea: Don't throw away the scalpel yet."
10/15/2009 - "Effects of heated humidification and topical steroids on compliance, nasal symptoms, and quality of life in patients with obstructive sleep apnea syndrome using nasal continuous positive airway pressure."
|1.||Continuous Positive Airway Pressure
08/15/2013 - "Continuous positive airway pressure is the most common and effective treatment for obstructive sleep apnea. "
07/01/2013 - "Despite the severity of obstructive sleep apnea in the propositus, the administration of continuous positive airway pressure was highly effective in alleviating his symptoms. "
12/01/2011 - "Continuous positive airway pressure (CPAP) is a highly efficacious treatment for obstructive sleep apnea (OSA) but adherence to the treatment limits its overall effectiveness across all age groups of patients. "
07/01/2010 - "Application of continuous positive airway pressure (CPAP) is effective in most of the patients and attenuates cardiodepressive hemodynamic effects of obstructive sleep apnea."
01/01/2009 - "Continuous positive airway pressure (CPAP) applied via a tight-fitting mask is the most effective treatment for obstructive sleep apnea (OSA) and has potential to improve the cardiovascular prognosis in such patients. "
01/01/2015 - "Treatment with a mandibular advancement device is very effective in treating mild and moderate obstructive sleep apnea. "
01/01/2015 - "Therapeutic efficacy of a hybrid mandibular advancement device in the management of obstructive sleep apnea assessed with acoustic reflection technique."
01/01/2015 - "To evaluate the long term (48 months) therapeutic efficacy of a soft monobloc mandibular advancement device in adult patients with mild or moderate obstructive sleep apnea. "
01/01/2015 - "Long term therapeutic efficacy of a soft monobloc mandibular advancement device in adults with obstructive sleep apnea."
09/01/2013 - "Mandibular advancement device vs. CPAP in the treatment of obstructive sleep apnea: are they equally effective in Short term health outcomes?"
07/01/2003 - "The results of the study suggested that LAUP with adjunctive tonsillectomy is an effective treatment for patients with obstructive sleep apnea syndrome and retropalatal obstruction with a lower complication rate than standard surgical therapy (uvulopalatopharyngoplasty)."
05/01/2014 - "The objective of this study is to evaluate the efficacy of tonsillectomy in reduction of respiratory disturbance index (RDI) and other sleep study parameters in patients with obstructive sleep apnea (OSA). "
02/01/2013 - "The aim of our study was to evaluate the efficacy of RAUP with tonsillectomy in treatment of obstructive sleep apnea syndrome (OSAS). "
01/01/2009 - "To establish the efficacy of uvulopalatopharyngoplasty with tonsillectomy for treating selected patients with severe obstructive sleep apnea syndrome. "
05/01/2015 - "The purpose of this study was to determine the effect of tonsillectomy as a single procedure in the treatment of adult obstructive sleep apnea (OSA). "
01/01/2015 - "Anatomically Based Outcome Predictors of Treatment for Obstructive Sleep Apnea with Intraoral Splint Devices: A Systematic Review of Cephalometric Studies."
04/01/2010 - "Such splints are reported to negatively affect the condyle-disk relation in patients who exhibit disk displacement with reduction and to modify breathing features in patients with obstructive sleep apnea, although further studies are required to unequivocally demonstrate these findings. "
03/01/2001 - "The purpose of this study was to evaluate the effect of an oral appliance (Sleep Splint) for obstructive sleep apnea syndrome (OSAS) patients, and to examine problems with this therapy. "
11/01/2015 - "CPAP devices maintain upper airway patency using a pneumatic splint, thereby ameliorating the repetitive deoxygenation and reoxygenation characteristic of sleep in obstructive sleep apnea patients. "
12/01/2013 - "Predicting compliance for mandible advancement splint therapy in 96 obstructive sleep apnea patients."
01/01/2014 - "Studies have reported significant improvement of obstructive sleep apnea (OSA) in obese patients after bariatric surgery (BS). "
01/01/2007 - "This article reviews the principal studies that evaluate the modifications in obstructive sleep apnea after bariatric surgery, showing that surgery is an effective treatment for the management of OSAHS in morbidly obese patients."
08/01/2015 - "Bariatric surgery has been reported to be an effective treatment for obstructive sleep apnea (OSA). "
05/01/2015 - "Self-reported remission of obstructive sleep apnea following bariatric surgery: cohort study."
11/01/2013 - "The aim of this study was to investigate the clinical outcome of patients with obstructive sleep apnea (OSA) without admission to the intensive care unit after laparoscopic bariatric surgery. "