Idiopathic Hypersomnolence

A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)

Also Known As:

Networked: 32 relevant articles (2 outcomes, 3 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Narcolepsy
2.	Cataplexy
3.	Parkinson Disease (Parkinson's Disease)
4.	Sleep Apnea Syndromes (Sleep Apnea)
5.	Fatigue

Experts

1.	Mignot, Emmanuel: 3 articles (11/2009 - 01/2003)
2.	Inoue, Yuichi: 3 articles (10/2009 - 03/2002)
3.	Nishino, Seiji: 3 articles (02/2009 - 03/2002)
4.	Shimizu, Tetsuo: 2 articles (02/2009 - 03/2002)
5.	Kanbayashi, Takashi: 2 articles (02/2009 - 03/2002)
6.	Chiba, Shigeru: 2 articles (02/2009 - 03/2002)
7.	Vicennati, Valentina: 1 article (11/2009)
8.	Ribichini, Danilo: 1 article (11/2009)
9.	Poli, Francesca: 1 article (11/2009)
10.	Plazzi, Giuseppe: 1 article (11/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Idiopathic Hypersomnolence:

1.	modafinil (armodafinil)FDA Link 02/01/1998 - "Modafinil is also of great value in the treatment of idiopathic hypersomnia. " 11/01/2003 - "METHODS: A systematic chart review was conducted for 13 children (mean age 11.0+/-5.3 years, six males, 10 with narcolepsy and three with idiopathic hypersomnia) receiving modafinil. " 11/01/2003 - "OBJECTIVES: To determine the effects of modafinil on clinical manifestations of narcolepsy and idiopathic hypersomnia. " 02/01/2001 - "Conventional stimulants and the new stimulant modafinil have roles to play in the management of narcolepsy and idiopathic hypersomnia. " 07/01/2000 - "Modafinil is a novel medication recently approved for the treatment of narcolepsy and idiopathic hypersomnia. " Order ALL the reference details at left...
2.	orexins (orexin)IBA 11/01/2009 - "CONCLUSIONS: BMI-independent metabolic alterations and the relative hypophagia of patients with narcolepsy with cataplexy, as compared with patients with idiopathic hypersomnia without long sleep time, suggest that orexin-A influences the etiology of this phenotype. " 02/01/2009 - "Similar degrees of reduction were also observed in hypocretin non-deficient narcolepsy and in idiopathic hypersomnia, while those in OSAS (non central nervous system hypersomnia) were not altered. " 03/01/2002 - "We measured cerebrospinal fluid (CSF) hypocretin-1 levels in 11 patients with narcolepsy-cataplexy, five with narcolepsy without cataplexy and 12 with idiopathic hypersomnia (IHS). " 03/01/2002 - "CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia." 03/17/2007 - "BACKGROUND AND OBJECTIVE: To evaluate the distribution of clinical, electrophysiological and biological variables, and their relationship with the CSF hypocretin-1 levels, in patients with central hypersomnias diagnosed as narcolepsy-cataplexy (NC), narcolepsy without cataplexy (NnC) and idiopathic hypersomnia (IH) based on the ICSD-2 criteria. " Order ALL the reference details at left...
3.	STF 62247IBA 03/01/2009 - "The gold standard exam of narcolepsy with cataplexy is Hypocretin-1 dosage, but in patients without cataplexy and idiopathic hypersomnia, there are no specific diagnostic lab findings. " Order ALL the reference details at left...
4.	acetamideIBA 08/01/1996 - "Modafinil [(diphenyl-methyl)sulphinyl-2-acetamide] is a novel psychostimulant drug which is effective in the treatment of narcolepsy and idiopathic hypersomnia. " Order ALL the reference details at left...
5.	diphenyl (biphenyl)IBA 08/01/1996 - "Modafinil [(diphenyl-methyl)sulphinyl-2-acetamide] is a novel psychostimulant drug which is effective in the treatment of narcolepsy and idiopathic hypersomnia. " Order ALL the reference details at left...
6.	human HLA-DQB1 proteinIBA 03/01/2009 - "The present study describes the prevalence of HLA-DQB1*0602 allele in narcoleptics with and without cataplexy and in patients with idiopathic hypersomnia. " 03/01/2009 - "RESULTS: The prevalence of the HLA-DQB1*0602 allele was increased in idiopathic hypersomnia and in narcoleptic patients with and without cataplexy when compared to healthy subjects (p = 0.04; p = 0.03 and p < 0.0001, respectively). " 03/01/2009 - "OBJECTIVE: Narcolepsy (with and without cataplexy) and idiopathic hypersomnia, are disorders with common features but with different HLA-DQB1*0602 allele prevalence. " 03/01/2009 - "Prevalence of the HLA-DQB1*0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit in São Paulo." 11/01/2009 - "Patients with narcolepsy with cataplexy (all HLA DQB1*0602 positive and with cerebrospinal fluid orexin-A levels < 110 pg/mL) had a higher BMI and BMI-independent metabolic alterations, namely waist circumference, high-density lipoprotein cholesterol, and glucose/insulin ratio (an insulin resistance index), with respect to patients with idiopathic hypersomnia without long sleep time (cerebrospinal fluid orexin-A levels > 300 pg/mL). " Order ALL the reference details at left...
7.	tranilast (N 5')IBA 05/01/1997 - "Ten Caucasian males (mean age, 66 years) with polygraphically confirmed RBD (n = 5, idiopathic RBD: n = 5, RBD with Parkinson's disease), but without narcolepsy, idiopathic hypersomnia, or autoimmune disease, were recruited for this study, along with 10 Caucasian male controls (mean age, 63 years) without a history of sleep disorder or autoimmune disease. " 01/01/2003 - "METHODS: Diagnoses included classical narcolepsy (n=3), symptomatic narcolepsy (n=1), narcolepsy without cataplexy (n=4), idiopathic hypersomnia (n=5), hypersomnia associated with psychiatric disorders (n=5), and hypersomnia secondary to neurological disorders or of undetermined origin (n=9). " Order ALL the reference details at left...
8.	CytokinesIBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia. " Order ALL the reference details at left...
9.	Interleukin-6 (Interleukin 6)IBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia. " Order ALL the reference details at left...
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia. " Order ALL the reference details at left...

Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR) 01/01/1996 - "Mean sleep latency test (MSLT) and continuous polysomnographic recording (CPR) were done in 12 dysthymic patients, in comparison with 12 idiopathic hypersomnia patients, and 12 normal controls. " Order ALL the reference details at left...
2.	Anesthesia 07/01/1986 - "[Idiopathic hypersomnia and anesthesia]" Order ALL the reference details at left...