Idiopathic Hypersomnolence

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26 relevant articles (1 outcomes, 2 trials/studies) found for this Disease

Description: A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)

Also Known As:

Hypersomnolence, Idiopathic; Idiopathic Central Nervous System Hypersomnolence; Idiopathic Hypersomnia; CNS Hypersomnolence, Idiopathic; CNS Hypersomnolences, Idiopathic; Hypersomnia, Idiopathic; Hypersomnias, Idiopathic; Hypersomnolence, Idiopathic CNS; Hypersomnolences, Idiopathic; Hypersomnolences, Idiopathic CNS; Idiopathic CNS Hypersomnolences; Idiopathic Hypersomnias; Idiopathic Hypersomnolences; Hypersomnolence, CNS, Idiopathic; Idiopathic CNS Hypersomnolence

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3414

Sleep Disorders: 653

Dyssomnias: 8

Intrinsic Sleep Disorders: 6

Disorders of Excessive Somnolence: 248

Idiopathic Hypersomnolence: 26

Mental Disorders: 1709

Sleep Disorders: 653

Dyssomnias: 8

Intrinsic Sleep Disorders: 6

Disorders of Excessive Somnolence: 248

Idiopathic Hypersomnolence: 26

Related Diseases

1.	Narcolepsy
2.	Parkinson Disease (Parkinson's Disease)
3.	Sleep Apnea Syndromes (Sleep Apnea)
4.	Fatigue
5.	Autoimmune Diseases (Autoimmune Disease)

Experts

1.	Inoue, Yuichi: 1 article (03/2002)
2.	Saito, Yasushi: 1 article (03/2002)
3.	Nishino, Seiji: 1 article (03/2002)
4.	Kanbayashi, Takashi: 1 article (03/2002)
5.	Fujii, Yukiharu: 1 article (03/2002)
6.	Chiba, Shigeru: 1 article (03/2002)
7.	Tsukamoto, Haruko: 1 article (03/2002)
8.	Aizawa, Rika: 1 article (03/2002)
9.	Shimizu, Tetsuo: 1 article (03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Idiopathic Hypersomnolence:

1.	modafinil (armodafinil)FDA Link 02/01/1998 - "Modafinil is also of great value in the treatment of idiopathic hypersomnia" 11/01/2003 - "METHODS: A systematic chart review was conducted for 13 children (mean age 11.0+/-5.3 years, six males, 10 with narcolepsy and three with idiopathic hypersomnia) receiving modafinil" 11/01/2003 - "OBJECTIVES: To determine the effects of modafinil on clinical manifestations of narcolepsy and idiopathic hypersomnia" 02/01/2001 - "Conventional stimulants and the new stimulant modafinil have roles to play in the management of narcolepsy and idiopathic hypersomnia" 07/01/2000 - "Modafinil is a novel medication recently approved for the treatment of narcolepsy and idiopathic hypersomnia" Order ALL the reference details at left...
2.	acetamideIBA 08/01/1996 - "Modafinil [(diphenyl-methyl)sulphinyl-2-acetamide] is a novel psychostimulant drug which is effective in the treatment of narcolepsy and idiopathic hypersomnia" Order ALL the reference details at left...
3.	diphenyl (biphenyl)IBA 08/01/1996 - "Modafinil [(diphenyl-methyl)sulphinyl-2-acetamide] is a novel psychostimulant drug which is effective in the treatment of narcolepsy and idiopathic hypersomnia" Order ALL the reference details at left...
4.	tranilast (N 5')IBA 05/01/1997 - "Ten Caucasian males (mean age, 66 years) with polygraphically confirmed RBD (n = 5, idiopathic RBD: n = 5, RBD with Parkinson's disease), but without narcolepsy, idiopathic hypersomnia, or autoimmune disease, were recruited for this study, along with 10 Caucasian male controls (mean age, 63 years) without a history of sleep disorder or autoimmune disease" 01/01/2003 - "METHODS: Diagnoses included classical narcolepsy (n=3), symptomatic narcolepsy (n=1), narcolepsy without cataplexy (n=4), idiopathic hypersomnia (n=5), hypersomnia associated with psychiatric disorders (n=5), and hypersomnia secondary to neurological disorders or of undetermined origin (n=9)" Order ALL the reference details at left...
5.	CytokinesIBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia" Order ALL the reference details at left...
6.	Interleukin-6 (Interleukin 6)IBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia" Order ALL the reference details at left...
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia" Order ALL the reference details at left...
8.	orexins (orexin)IBA 03/01/2002 - "We measured cerebrospinal fluid (CSF) hypocretin-1 levels in 11 patients with narcolepsy-cataplexy, five with narcolepsy without cataplexy and 12 with idiopathic hypersomnia (IHS)" 03/01/2002 - "CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia." 03/17/2007 - "BACKGROUND AND OBJECTIVE: To evaluate the distribution of clinical, electrophysiological and biological variables, and their relationship with the CSF hypocretin-1 levels, in patients with central hypersomnias diagnosed as narcolepsy-cataplexy (NC), narcolepsy without cataplexy (NnC) and idiopathic hypersomnia (IH) based on the ICSD-2 criteria" 12/01/2003 - "Hypocretin ligand deficiency appears not to be the major cause for other hypersomnias, with a possible continuum in the pathophysiology of narcolepsy without cataplexy and idiopathic hypersomnia" 01/01/2007 - "No human leukocyte antigen (HLA) association was present in idiopathic hypersomnia or in cases with normal cerebrospinal fluid (CSF) hypocretin-1" Order ALL the reference details at left...
9.	N-(4-aminophenethyl)spiroperidol (NAPS)IBA 02/01/1996 - "Mean durations of nocturnal sleep, daytime naps, and morning grogginess were not increased in idiopathic hypersomnia compared with other groups" 10/01/2007 - "Comparison with a similar group of patients with narcolepsy showed that those with idiopathic hypersomnia were more likely to have prolonged unrefreshing daytime naps, a positive family history, increased slow-wave sleep, and a longer sleep latency on the Multiple Sleep Latency Test" 08/01/1997 - "Only 29% of subjects had 'classic' idiopathic hypersomnia with non-imperative sleepiness, long unrefreshing naps, prolonged night-time sleep, difficult awakening with sleep drunkenness and prominent mood disturbances" Order ALL the reference details at left...
10.	MelatoninIBA 01/01/2000 - "Significant differences were found between our patients and the control group in idiopathic hypersomnia--acrophase of melatonin was delayed and secretion was prolonged" Order ALL the reference details at left...

Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR) 01/01/1996 - "Mean sleep latency test (MSLT) and continuous polysomnographic recording (CPR) were done in 12 dysthymic patients, in comparison with 12 idiopathic hypersomnia patients, and 12 normal controls" Order ALL the reference details at left...
2.	Anesthesia 07/01/1986 - "Idiopathic hypersomnia and anesthesia]" Order ALL the reference details at left...

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