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P-Glycoprotein

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Also Known As:
ATP-Binding Cassette, Sub-Family B, Member 1; P-gp; PGY-1 Protein; P Glycoprotein; PGY 1 Protein; MDR1 Protein; Multidrug Resistance Protein 1
Networked: 5596 relevant articles (205 outcomes, 830 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Beijnen, Jos H: 36 articles (12/2015 - 04/2004)
2. Ambudkar, Suresh V: 30 articles (10/2015 - 08/2002)
3. Löscher, Wolfgang: 28 articles (06/2015 - 04/2002)
4. Lage, Hermann: 28 articles (04/2015 - 02/2002)
5. Gottesman, Michael M: 25 articles (09/2015 - 07/2002)
6. Efferth, Thomas: 24 articles (12/2015 - 01/2003)
7. Schinkel, Alfred H: 22 articles (12/2015 - 03/2003)
8. Potschka, Heidrun: 21 articles (01/2014 - 04/2002)
9. Elmquist, William F: 20 articles (11/2015 - 05/2007)
10. Molnár, Joseph: 20 articles (11/2015 - 01/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Alzheimer Disease (Alzheimer's Disease)
4. Leukemia
5. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)

Related Drugs and Biologics

1. P-Glycoprotein
2. Paclitaxel (Taxol)
3. Doxorubicin (Adriamycin)
4. Carbon Monoxide
5. Amyloid (Amyloid Fibrils)
6. Proteins (Proteins, Gene)
7. Adenosine Triphosphate (ATP)
8. Multidrug Resistance-Associated Proteins
9. Daunorubicin (Cerubidine)
10. Small Interfering RNA (siRNA)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Remission Induction
3. Therapeutics
4. Heterologous Transplantation (Xenotransplantation)
5. Combination Drug Therapy (Combination Chemotherapy)