|1.||Beijnen, Jos H: 36 articles (12/2015 - 04/2004)|
|2.||Ambudkar, Suresh V: 30 articles (10/2015 - 08/2002)|
|3.||Löscher, Wolfgang: 28 articles (06/2015 - 04/2002)|
|4.||Lage, Hermann: 28 articles (04/2015 - 02/2002)|
|5.||Gottesman, Michael M: 25 articles (09/2015 - 07/2002)|
|6.||Efferth, Thomas: 24 articles (12/2015 - 01/2003)|
|7.||Schinkel, Alfred H: 22 articles (12/2015 - 03/2003)|
|8.||Potschka, Heidrun: 21 articles (01/2014 - 04/2002)|
|9.||Elmquist, William F: 20 articles (11/2015 - 05/2007)|
|10.||Molnár, Joseph: 20 articles (11/2015 - 01/2002)|
06/01/2007 - "curtisii extract may play an important role as a P-gp modulator as used in vitro and may be effective in the treatment of multidrug-resistant cancers. "
07/10/2015 - "In vivo detection of the emergence of P-glycoprotein (Pgp) mediated multidrug resistance in tumors could be beneficial for patients treated with anticancer drugs. "
05/12/2015 - "Because of the enhanced intracellular and nuclear drug accumulation through effective inhibition of the P-gp efflux transporter, DOX/TQR coloaded nanovesicles showed significantly improved tumor cell inhibitory efficiency, especially for drug-resistant cells. "
05/01/2015 - "Nanocarriers are beneficial in the transport of chemotherapeutics by their ability to bypass the P-gp efflux in cancers. "
03/01/2015 - "This therapeutic improvement in response to Dox was attributed to the significant, sequence-specific P-gp downregulation in excised tumors mediated by the DOPE-PEI formulations. "
|2.||Breast Neoplasms (Breast Cancer)
08/01/2015 - "We conclude that peloruside is highly effective in preventing the growth of lung and P-glycoprotein-overexpressing breast tumors in vivo and that further therapeutic development is warranted. "
01/01/1996 - "p-gp is frequently expressed in patients with untreated breast cancer, with p-gp-positive patients being at significantly greater risk for disease recurrence. "
11/01/2014 - "Exosomes are effective in transferring drug resistance as well as P-gp from drug-resistant breast cancer cells to sensitive ones. "
06/01/2010 - "This work demonstrates that the ACMS-GOX are effective in circumventing P-gp-mediated MDR in breast cancer cells."
06/01/2015 - "Various studies examined whether AEDs are substrates of P-glycoprotein (Pgp; MDR1; ABCB1), whereas information about the potential role of breast cancer resistance protein (BCRP; ABCG2) is scanty. "
|3.||Alzheimer Disease (Alzheimer's Disease)
08/01/2011 - "In this study, we aimed to investigate the possibility of P-gp as a potential therapeutic target for Alzheimer's disease by examining the impact of P-gp up-regulation on the clearance of Aβ, a neuropathological hallmark of Alzheimer's disease. "
08/01/2011 - "Our results elucidate the importance of targeting Aβ clearance via P-gp up-regulation, which will be effective in slowing or halting the progression of Alzheimer's disease."
12/01/2012 - "Thus, VDR activation up-regulates Mdr1/MDR1 and P-gp protein in isolated rat brain capillaries and rodent and human brain microvascular endothelia, implicating a role for VDR in increasing the brain clearance of P-gp substrates, including hAβ(42), a plaque-forming precursor in Alzheimer's disease."
05/01/2004 - "These findings led us to hypothesize that P-gp might be involved in the clearance of Abeta in normal aging and particularly in Alzheimer's disease (AD). "
01/01/2012 - "The purpose of this study was to assess the effects of C1236T, G2677T/A and C3435T single-nucleotide polymorphisms in ABCB1 on blood-brain barrier P-glycoprotein function in healthy subjects and patients with Alzheimer's disease. "
04/01/1997 - "In 31 acute leukemia patients at initial diagnosis, mdr1 or mdr3 P-gp expression correlated significantly to an outcome of complete remission (CR). "
12/01/1995 - "Complete remission (CR) was achieved in 12/14 (85%) children's and 9/11 (81%) adults' P-gp (+) leukemia cases. "
08/01/2010 - "miR-138 could significantly down-regulate the expression of P-glycoprotein, Bcl-2, and the transcription of the multidrug resistance gene 1. Further study of the biological functions of miR-138 might be helpful for developing possible strategies to treat leukemia."
12/01/2000 - "The remission rate of acute leukemia patients is significantly lower in P-gp+ patients than in P-gp- patients. "
02/01/2014 - "The present study aimed to explore the effect of As2O3 on the expression and regulation of P-gp in leukemia cells, and elucidate the mechanism of the reversal of drug resistance. "
|5.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
07/11/2012 - "Univariate analysis revealed that there was a significant difference between complete remission rates for acute myelogenous leukemia patients depending on their blast cell expressions, between LRP positive versus negative, P-gp positive versus negative, and LRP/P-gp double positive versus other groups. "
06/01/1994 - "In order to further define the role of the MDR1 gene in acute myeloid leukemia (AML), we determined the association between the presence of P-glycoprotein on leukemic cells and the efficacy of therapy in patients with AML. "
11/18/2010 - "Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999."
02/01/1999 - "To study the immunophenotype and P-glycoprotein expression in CD7 positive adult acute myeloid leukemia (CD7+ AML). "
02/01/1996 - "From these results, if we can clarify the mechanism of MDR and the relationship between MDR and cytogenetic or clinical features of ANLL with further study, P-gp expression may become a useful marker for predicting the outcome of ANLL."
|5.||Amyloid (Amyloid Fibrils)
|6.||Proteins (Proteins, Gene)
|7.||Adenosine Triphosphate (ATP)
|8.||Multidrug Resistance-Associated Proteins
|10.||Small Interfering RNA (siRNA)
|1.||Drug Therapy (Chemotherapy)
|4.||Heterologous Transplantation (Xenotransplantation)
|5.||Combination Drug Therapy (Combination Chemotherapy)