Brefeldin A

A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.

Also Known As:

Ascotoxin; Cyanein; Decumbin; NSC-89671; Synergisidin; NSC 89671; NSC89671; 4H-Cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-

Networked: 211 relevant articles (2 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Polyketides: 231
    - Macrolides: 4391
      - Brefeldin A: 211
        brefeldin A formylate: 1
        2,3-dihydro-(2-hydroxypropylsulfinyl)brefeldin A
        2,3-dihydro-(2-hydroxypropylthio)brefeldin A
        4-oxo-brefeldin A
        breflate

Experts

1.	Katagiri, Toyomasa: 7 articles (10/2021 - 08/2009)
2.	Yoshimaru, Tetsuro: 6 articles (10/2021 - 07/2014)
3.	Déry, Marc-André: 3 articles (01/2017 - 03/2013)
4.	LeBlanc, Andréa C: 3 articles (01/2017 - 03/2013)
5.	Liu, Ming: 2 articles (01/2022 - 10/2021)
6.	Shao, Chang-Lun: 2 articles (01/2022 - 10/2021)
7.	Zhang, Jin-Man: 2 articles (01/2022 - 10/2021)
8.	Matsushita, Yosuke: 2 articles (10/2021 - 12/2017)
9.	Nakamura, Yusuke: 2 articles (09/2021 - 08/2009)
10.	Fang, Hao: 2 articles (07/2021 - 01/2020)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "Brefeldin A (BFA), a well-known natural Arf-GEFs inhibitor, is effective against hepatocellular carcinoma (HCC), while the poor solubility, serious toxicity, and short half-life limit its potential. " 05/01/2000 - "High-pressure freezing and freeze-substitution were used to study Golgi ultrastructure and its brefeldin A-induced transformations in HepG2 human hepatoma cells. " 01/01/2013 - "Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells." 06/15/1992 - "The cell surface expression of three endocytic receptors was studied in human hepatoma Hep G2 cells treated with brefeldin A (BFA). " 10/01/2021 - "Brefeldin A delivery nanomicelles in hepatocellular carcinoma therapy: Characterization, cytotoxic evaluation in vitro, and antitumor efficiency in vivo."
2.	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 09/01/2015 - "To obtain further insights into the biological differences of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ ALCL) and classical Hodgkin lymphoma (HL), we screened microbial culture filtrates to search for compounds that would exert a significantly greater effect on the viability of ALK+ ALCL cell lines compared to HL cell lines and identified Brefeldin A (BFA) as a suitable candidate. " 09/01/2015 - "Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines."
3.	Hodgkin Disease (Hodgkin's Disease) 09/01/2015 - "To obtain further insights into the biological differences of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ ALCL) and classical Hodgkin lymphoma (HL), we screened microbial culture filtrates to search for compounds that would exert a significantly greater effect on the viability of ALK+ ALCL cell lines compared to HL cell lines and identified Brefeldin A (BFA) as a suitable candidate. " 09/01/2015 - "Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines."
4.	Neoplasms (Cancer) 05/23/2023 - "Brefeldin A has a wide range of anticancer activity against a variety of tumor cells. " 08/01/2022 - "Penipentenone A and brefeldin A derivatives potently inhibit KRAS mutant cancer cells from an endophytic fungus Penicillium brefeldianum F4a." 01/01/2020 - "Brefeldin A (BFA) has been known to induce endoplasmic reticulum stress (ERS) and Golgi body stress in cancer cells. " 11/01/2013 - "Brefeldin A induces apoptosis in various cancer cells; however, the apoptotic process in cancer cells exposed to brefeldin A remains unclear. " 09/01/2013 - "Brefeldin A has attracted considerable attention because of its potential function in cancer prevention. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "We examined the effects of Brefeldin A (BFA), a fungal metabolite known to disrupt the Golgi structure, in TPD52-expressing 3T3 cells, and in human AU565 and HMC-1-8 breast cancer cells that endogenously express TPD52. " 01/01/2017 - "Luman activity was transcriptionally and proteolytically activated by the ER stressing drug brefeldin A (BFA) in human neurons, astrocytes, and breast cancer MCF-7 cells. " 10/29/2014 - "Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells." 01/01/2023 - "5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A: Design, synthesis and cytotoxicity in MDA-MB-231 human breast cancer cells." 04/28/2022 - "Human Estrogen Receptor Alpha Antagonists, Part 3: 3-D Pharmacophore and 3-D QSAR Guided Brefeldin A Hit-to-Lead Optimization toward New Breast Cancer Suppressants."

Related Drugs and Biologics

1.	Anaplastic Lymphoma Kinase
2.	Proteins (Proteins, Gene)
3.	Guanine Nucleotides
4.	2,3- bis(2- hydroxyethylsulfanyl)- (1,4)naphthoquinone
5.	sanguinarine
6.	Thapsigargin
7.	Tunicamycin
8.	Glycoproteins (Glycoprotein)
9.	Messenger RNA (mRNA)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)