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Iodocyanopindolol

A highly selective and specific beta antagonist that is used to characterize beta-adrenoceptors.
Also Known As:
I-Cyanopindolol; I Cyanopindolol; ICYP; 1H-Indole-2-carbonitrile, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-3-iodo-
Networked: 57 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Feringa, Ben L: 1 article (02/2014)
2. Elsinga, Philip H: 1 article (02/2014)
3. Dierckx, Rudi A J O: 1 article (02/2014)
4. Campbell-Verduyn, Lachlan: 1 article (02/2014)
5. Rybczynska, Anna A: 1 article (02/2014)
6. van Waarde, Aren: 1 article (02/2014)
7. Mirfeizi, Leila: 1 article (02/2014)
8. Abu-Taha, Issam Hissam: 1 article (03/2009)
9. Bärtsch, Peter: 1 article (03/2009)
10. Balo─člu, Emel: 1 article (03/2009)

Related Diseases

1. Necrosis
2. Premature Obstetric Labor (Premature Labor)
3. Heart Failure
06/01/2005 - "We assessed in right atria, obtained from patients at different stages of heart failure, treated with or not treated with beta-adrenoceptor blockers, and in the four chambers of explanted hearts, obtained from patients with end-stage heart failure, beta-adrenoceptor density (by (-)-[(125)I]-iodocyanopindolol binding) and GRK activity (by an in vitro rhodopsin phosphorylation assay). "
08/01/1992 - "We investigated right auricular (RA) and left ventricular (LV) beta-adrenoceptors characteristics (125 I cyanopindolol binding) in two groups of patients undergoing valve replacement without heart failure (LV ejection fraction > 55%). "
05/01/1992 - "Using a quantitative autoradiographic technique with 125I-cyanopindolol (ICYP), the density and transmural distribution of beta adrenergic receptors were compared between eight cardiomyopathic BIO 14.6 Syrian hamsters with heart failure and six normal age matched controls (BIO 14.6HAM). "
02/15/1990 - "Despite the fact that beta receptor density was decreased by 50% in failing hearts (iodocyanopindolol Bmax 84.4 +/- 8.9 fmol/mg protein in nonfailing hearts vs 42.9 +/- 3.2 fmol/mg in failing hearts, P less than 0.01), dihydropyridine calcium antagonist binding sites were not reduced significantly by heart failure. "
07/01/1995 - "To study possible mechanisms underlying this process, we assessed in right atrial appendages from 52 patients of different ages (group A, < 20 years, mean age 3.7 +/- 1.0 years, n = 20; group B, 20-50 years, mean age, 37.9 +/- 2.3 years, n = 9; group C, > 50 years, mean age 66.1 +/- 1.5 years, n = 23) without apparent heart failure who were undergoing open heart surgery beta-adrenoceptor number and subtype distribution (by (-)-[125I]-iodocyanopindolol [ICYP] binding), adenylyl cyclase activity, and Gs- and Gi-protein alpha-subunits (by quantitative Western blotting). "
4. Neoplasms (Cancer)
5. Sepsis (Septicemia)

Related Drugs and Biologics

1. Prazosin (Minipress)
2. Isoproterenol (Isoprenaline)
3. Calcium
4. Amlodipine (Norvasc)
5. Isradipine (Dynacirc)
6. Iodocyanopindolol
7. Adenylate Cyclase (Adenylyl Cyclase)
8. beta Adrenergic Receptors
9. Adrenergic Antagonists (Antiadrenergic Agents)
10. Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1. Surgical Instruments (Clip)
2. Coronary Artery Bypass (Coronary Artery Bypass Surgery)