Pepsinogen A (Pepsinogen)

This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.

Also Known As:

Networked: 1348 relevant articles (34 outcomes, 177 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Leja, Marcis: 14 articles (05/2022 - 11/2009)
2.	Haruma, Ken: 14 articles (09/2014 - 02/2002)
3.	Ito, Masanori: 13 articles (01/2022 - 05/2002)
4.	Ichinose, Masao: 13 articles (01/2016 - 03/2004)
5.	Fujishiro, Mitsuhiro: 13 articles (05/2014 - 10/2006)
6.	Tanaka, Shinji: 12 articles (01/2022 - 05/2002)
7.	Yoshihara, Masaharu: 12 articles (04/2019 - 02/2002)
8.	Yuan, Yuan: 11 articles (12/2020 - 09/2006)
9.	Kim, Nayoung: 11 articles (01/2020 - 04/2008)
10.	Chayama, Kazuaki: 11 articles (09/2017 - 02/2002)

Related Diseases

1.	Infections 01/01/2017 - "Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of Helicobacter pylori Infection in Subjects with Seemingly Normal Pepsinogen Levels." 09/01/2012 - "Serum pepsinogen and Helicobacter pylori infection--a Japanese population study." 12/15/2007 - "pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only." 01/01/2023 - "New serum pepsinogen (PG) criteria have been shown to indicate more accurately infection with Helicobacter pylori (H. " 12/01/2022 - "Useful Serum Pepsinogen Levels for Detecting Ongoing Helicobacter pylori Infection in Asymptomatic Subjects: A Cross-Sectional Study Based on 13C-urea Breath Test Findings."
2.	Gastritis 01/01/2022 - "The aim of this study was to evaluate the standard values for gender- and age-stratified serum pepsinogen (sPG) in Helicobacter pylori (H. pylori) non-infected children and to determine the optimal cut-off values of sPG for predicting H. pylori-infected gastritis in children. " 06/28/2020 - "In the Helsinki Gastritis Study, 22346 elderly male smokers from southwestern Finland were screened for serum pepsinogen I (PGI). " 09/01/2001 - "The study population was randomly selected among 12,252 Finnish men who were screened for atrophic corpus gastritis with serum pepsinogen I-assay (S-PGI). " 08/01/2023 - "Clinical data and serum gastric function parameters, PGI (pepsinogen I), PGII, PGR (PGI/II), and G-17 (gastrin-17) of 117 patients with chronic gastritis were collected, including 57 H. " 01/01/2023 - "Pepsinogen levels were normal, and none of the findings suggested autoimmune gastritis. "
3.	Duodenal Ulcer (Curling's Ulcer) 12/01/1997 - "The present study examines the polymorphism of pepsinogen by PAGE in 155 duodenal ulcer cases and 92 control subjects. " 01/01/1996 - "To study basal pepsinogen I levels in patients with duodenal ulcer and in subjects with normal endoscopy, depending on Helicobacter pylori status. " 08/01/1990 - "Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. " 11/01/1986 - "In 1958 the Yale freshman class gave blood samples as part of a study intended to determine the predictive value of plasma pepsinogen (PP) for the subsequent development of duodenal ulcer (DU). " 01/01/1973 - "[Study of serum pepsinogen fractions in patients with duodenal ulcer]."
4.	Weight Gain 11/01/1991 - "Egg counts, herbage larval counts, worm counts of tracer calves, pepsinogen concentrations and weight gains showed a high efficacy of the strategic treatment in group 3 against gastrointestinal nematodes. " 08/01/1997 - "The efficacy of MSRT was assessed by comparison of parasitological data (faecal worm egg counts, herbage larval counts, worm counts from tracer calves and set-stocked trial calves, determination of haematological parameters and pepsinogen levels), weight gains and clinical status of the animals. " 04/01/1987 - "The efficacy of the bolus was assessed by comparison of weight gain performance and parasitological data (fecal worm egg counts, herbage larval counts, worm counts from tracer and principal trial calves, and plasma pepsinogen level determinations). " 09/15/2017 - "Neither FEC nor pepsinogen values were significantly associated with live weight gain. " 04/02/2001 - "Egg counts (EPG), larval cultures, pasture larval counts, serum pepsinogen (Pep) and live weight gain (LWG) were recorded monthly. "
5.	Stomach Neoplasms (Stomach Cancer) 08/01/2010 - "This study was performed to compare the efficacy of non-invasive gastric cancer screening through the measurement of pepsinogen (PG) I/II ratio and endoscopic screening using histologic criteria (Meining's risk index for gastric cancer) in Korean patients. " 01/01/2022 - "Serum pepsinogen testing holds promise as a noninvasive screening strategy to triage individuals at heightened risk for gastric cancer, and may help to improve early diagnosis in the United States. " 05/07/2022 - "Plasma Pg was measured and upper endoscopy with biopsy was performed within the "Multicentric randomized study of Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the GISTAR study". " 01/01/2021 - "This study determined the reference interval of pepsinogen (PG) of healthy people in the local region to provide a basis for early screening of gastric cancer. " 01/01/2021 - "Human gastric cancer risk screening: From rat pepsinogen studies to the ABC method."

Related Drugs and Biologics

1.	Gastrins
2.	Pepsinogen C
3.	Pepsinogen A (Pepsinogen)
4.	Immunoglobulin G (IgG)
5.	Acids
6.	Antibodies
7.	gastrin 17 (G 17)
8.	Prostaglandins A
9.	Somatostatin (Somatotropin Release-Inhibiting Factor)
10.	Blood Proteins (Serum Proteins)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Gastrectomy
4.	Vagotomy
5.	Bariatric Surgery