|1.||Mitsumori, Kunitoshi: 5 articles (12/2003 - 06/2002)|
|2.||Watanabe, Takao: 3 articles (03/2003 - 06/2002)|
|3.||Kashida, Yoko: 3 articles (03/2003 - 06/2002)|
|4.||Onodera, Hiroshi: 3 articles (03/2003 - 06/2002)|
|5.||Hirose, Masao: 3 articles (03/2003 - 06/2002)|
|6.||Hulla, J E: 3 articles (12/2001 - 01/2001)|
|7.||French, J E: 3 articles (04/2001 - 01/2001)|
|8.||Dunnick, J K: 3 articles (04/2001 - 01/2001)|
|9.||Söderkvist, Peter: 2 articles (12/2008 - 05/2002)|
|10.||Karlsson, Anneli: 2 articles (12/2008 - 05/2002)|
|1.||Chromosome Aberrations (Chromosome Abnormalities)
01/01/1995 - "The positive results obtained with phenolphthalein in vivo were consistent with the results of an in vitro chromosomal aberration test in Chinese hamster ovary cells, where dose-related increases in aberrations were noted only in cells treated in the presence of induced rat liver S9."
12/20/2000 - "Induction of chromosome aberrations in vitro by phenolphthalein: mechanistic studies."
12/20/2000 - "Chromosome aberration (Ab) induction by phenolphthalein in vitro is associated with marked cytotoxicity. "
01/01/2000 - "Our results show that phenolphthalein induces a significant increase in the frequency of chromosome aberrations in human cells. "
01/01/2000 - "In order to assess cytogenetic effects on human cells in vitro, we tested phenolphthalein in a chromosome aberration assay in human embryo cells derived from amniotic fluid. "
03/14/2003 - "Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in female heterozygous p53-knockout TSG mice (C57BL/6 background) at the same dose in a 6-month study. "
05/01/2000 - "Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in heterozygous p53-deficient female mice at the same dose in a 6-month study. "
04/01/2006 - "Dietary phenolphthalein reduced survival in both sexes and early deaths were attributed to thymic lymphoma. "
03/14/2003 - "Unequivocal induction of neoplastic lesions was not apparent, suggesting that p53 (+/-) CBA mice and p53 (+/-) CIEA mice are resistant to the induction of malignant lymphomas by the treatment of phenolphthalein."
12/27/2002 - "(2) Malignant lymphomas are induced by the treatment of phenolphthalein in p53 (+/-) C57Bl/6 mice, in which exon 5 of the lateral p53 allele was inactivated, but not in p53 (+/-) CBA and C57Bl/6 mice, in which exon 2 of the p53 allele was inactivated. "
11/01/1997 - "Earlier studies showed that phenolphthalein caused carcinogenic effects in Fisher 344 rats and B6C3F1 mice after a 2-yr dosing period (Dunnick and Hailey, Cancer Res. 56: 4922-4926, 1996). "
11/01/1996 - "One of the sites for neoplasm that is of particular concern is the ovary, and epidemiology studies are under way to identify any potential effects of phenolphthalein exposure at this site in humans."
06/01/2013 - "Phenolphthalein (PHT) induces tumors in rodents but its primary mechanism does not seem to be DNA damage. "
09/01/2009 - "(124)I-PTH-G was selectively converted to (124)I-PTH (phenolphthalein), which accumulated in CT26/betaG cells and tumors in vitro. "
01/01/2001 - "Finally, phenolphthalein induced p53 LOH in all tumors analyzed (21/21). "
|4.||Body Weight (Weight, Body)
12/01/2007 - "27-WEEK STUDY IN MICE: Groups of 15 male and 15 female mice were exposed to 0, 200, 375, 750, 3,000, or 12,000 ppm phenolphthalein (equivalent to average daily doses of approximately 35, 65, 135, 540, and 2,170 mg phenolphthalein/kg body weight to males and 50, 90, 170, 680, 2,770 mg/kg to females) in feed for 27 weeks. "
01/01/1992 - "Although there were no effects on body weight gain, elevated liver weights were noted in female mice receiving 6000-50,000 ppm phenolphthalein. "
01/01/1992 - "Several treatment-related toxic effects, however, were identified in mice who received more phenolphthalein per unit body weight than rats. "
01/01/1992 - "On a milligram per kilogram body weight basis, rats and mice fed 50,000 ppm phenolphthalein ingested more drug than would be expected during human laxative abuse. "
02/01/1985 - "with a dose of 15 mg/kg body weight of phenolphthalein. "
04/01/1993 - "The purpose of the present study was to test the validity of this hypothesis in normal subjects in whom secretory diarrhea was induced by phenolphthalein. "
01/01/1997 - "On days 5-8, diarrhea was induced by ingestion of phenolphthalein. "
09/01/1982 - "Phenolphthalein laxatives and factitious diarrhea."
01/01/1965 - "On the mechanism of diarrhea due to phenolphthalein."
11/01/1964 - "FACTITIOUS DIARRHEA INDUCED BY PHENOLPHTHALEIN."
|6.||Diethylhexyl Phthalate (DEHP)