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Phenolphthalein (Modane)

An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.
Also Known As:
Modane; Ap-La-Day; Ex-Lax; Feen-A-Mint; Laxatone; Laxettes; Thalinol; 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
Networked: 112 relevant articles (1 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Mitsumori, Kunitoshi: 5 articles (12/2003 - 06/2002)
2. Hirose, Masao: 3 articles (03/2003 - 06/2002)
3. Kashida, Yoko: 3 articles (03/2003 - 06/2002)
4. Onodera, Hiroshi: 3 articles (03/2003 - 06/2002)
5. Watanabe, Takao: 3 articles (03/2003 - 06/2002)
6. Hulla, J E: 3 articles (12/2001 - 01/2001)
7. Dunnick, J K: 3 articles (04/2001 - 01/2001)
8. French, J E: 3 articles (04/2001 - 01/2001)
9. Balayssac, Stéphane: 2 articles (03/2020 - 05/2016)
10. Gilard, Véronique: 2 articles (03/2020 - 05/2016)

Related Diseases

1. Chromosome Aberrations (Chromosome Abnormalities)
2. Lymphoma (Lymphomas)
3. Body Weight (Weight, Body)
12/01/2007 - "27-WEEK STUDY IN MICE: Groups of 15 male and 15 female mice were exposed to 0, 200, 375, 750, 3,000, or 12,000 ppm phenolphthalein (equivalent to average daily doses of approximately 35, 65, 135, 540, and 2,170 mg phenolphthalein/kg body weight to males and 50, 90, 170, 680, 2,770 mg/kg to females) in feed for 27 weeks. "
11/01/1996 - "2-YEAR STUDY IN MICE: Groups of 50 male and 50 female B6C3F1 mice were given 0, 3,000, 6,000, or 12,000 ppm phenolphthalein (equivalent to average daily doses of approximately 300, 600, or 1,200 mg phenolphthalein/kg body weight to males and 400, 800, or 1,500 mg/kg to females) in feed for 2 years. "
11/01/1996 - "2-YEAR STUDY IN RATS: Groups of 50 male and 50 female F344/N rats were given 0, 12,000, 25,000, or 50,000 ppm phenolphthalein (equivalent to average daily doses of approximately 500, 1,000, or 2,000 mg phenolphthalein/kg body weight to males and 500, 1,000, or 2,500 mg/kg to females) in feed for 2 years. "
11/01/1996 - "13-WEEK STUDY IN MICE: Groups of 10 male and 10 female B6C3F1 mice were given 0, 3,000, 6,000, 12,000, 25,000, or 50,000 ppm phenolphthalein (equivalent to average daily doses of approximately 500, 1,000, 2,000, 4,100, or 9,000 mg phenolphthalein/kg body weight to males and 600, 1,200, 2,400, 5,000, or 10,500 mg/kg to females) in feed for 13 weeks. "
11/01/1996 - "13-WEEK STUDY IN RATS: Groups of 10 male and 9 or 10 female F344/N rats were given 0, 3,000, 6,000, 12,000, 25,000, or 50,000 ppm phenolphthalein (equivalent to average daily doses of approximately 200, 400, 800, 1,600, or 3,500 mg phenolphthalein/kg body weight to males and 200, 400, 800, 1,700, or 3,600 mg/kg to females) in feed for 13 weeks. "
4. Neoplasms (Cancer)
5. Constipation

Related Drugs and Biologics

1. Laxatives
2. sibutramine (Meridia)
3. Bisacodyl (Bicol)
4. Glucuronidase
5. Carcinogens
6. Zalcitabine (Hivid)
7. 1,3-butadiene (divinyl)
8. Cyclin-Dependent Kinase Inhibitor p16
9. Zearalenone
10. Antipsychotic Agents (Antipsychotics)

Related Therapies and Procedures

1. Intraperitoneal Injections
2. Massage (Zone Therapy)
3. Aftercare (After-Treatment)
4. Therapeutics
5. Oral Administration