Cathepsin E

An aspartic endopeptidase that is similar in structure to CATHEPSIN D. It is found primarily in the cells of the immune system where it may play a role in processing of CELL SURFACE ANTIGENS.

Also Known As:

Erythrocyte Membrane Aspartic Proteinase; Slow Moving Proteinase; Moving Proteinase, Slow; Proteinase, Slow Moving

Networked: 81 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yamamoto, Kenji: 17 articles (01/2019 - 07/2003)
2.	Tsukuba, Takayuki: 10 articles (03/2014 - 07/2003)
3.	Kawakubo, Tomoyo: 8 articles (05/2014 - 11/2007)
4.	Kadowaki, Tomoko: 7 articles (03/2014 - 12/2003)
5.	Yasukochi, Atsushi: 6 articles (05/2014 - 11/2007)
6.	Okamoto, Kuniaki: 6 articles (03/2014 - 12/2003)
7.	Nakanishi, Hiroshi: 4 articles (01/2022 - 09/2015)
8.	Ni, Junjun: 4 articles (01/2022 - 09/2015)
9.	Wu, Zhou: 4 articles (01/2022 - 09/2015)
10.	Cruz-Monserrate, Zobeida: 4 articles (10/2019 - 12/2011)

Related Diseases

1.	Graft vs Host Disease (Graft-Versus-Host Disease) 01/01/2017 - "Cathepsin E Deficiency Ameliorates Graft-versus-Host Disease and Modifies Dendritic Cell Motility."
2.	Neoplasms (Cancer) 01/01/2012 - "Recent genetic and pharmacological studies have particularly suggested that cathepsin E plays an important role in host defense against cancer cells and invading microorganisms. " 12/01/2011 - "The purpose of this study is to demonstrate the ability of imaging Cathepsin E (Cath E) positive tumors in living animals through selective targeting of Cath E proteolytic activity using a sensitive molecular imaging agent. " 11/15/2007 - "The antitumor activity of cathepsin E was corroborated by in vivo studies with mice bearing human and mouse tumor transplants. " 01/01/2020 - "Our findings suggest that grassystatin-like inhibitors are useful tools for targeted inhibition of cathepsin E and thus provide a novel approach for cancer and immunology research." 01/01/2016 - "Here we show that cathepsin E expression in mouse PDAC tumors is increased by more than 400-fold when compared to healthy pancreatic tissue. "
3.	Stomach Neoplasms (Stomach Cancer) 06/01/2001 - "The aim of this study was to find out the role of cathepsin E in IM, dysplasia and cancer of stomach. " 11/01/1995 - "However, Med.P disappeared when the samples prepared from gastric cancer tissues were left for over 4 weeks at -80 degrees C, whereas the activity of cathepsin E (CE) increased. " 11/01/1995 - "Conversion of cathepsin E to enzymatic unstable form in gastric cancer cells." 11/01/1988 - "Slow moving proteinase in gastric cancer and its relationship to pepsinogens I and II. An immunohistochemical study." 09/01/1993 - "Expression of SH-9 reactive mucin and of cathepsin E were therefore investigated as possible additional markers to distinguish between the gastric cancer cell type in 203 primary stomach cancers. "
4.	Bacterial Infections (Bacterial Infection) 07/01/2006 - "In the present study, we investigated the role of cathepsin E in immune defense systems against bacterial infection. " 05/01/2009 - "Previous studies have shown that cathepsin E-deficient (CatE(-/-)) mice display aberrant immune responses such as atopic dermatitis and higher susceptibility to bacterial infection. " 07/01/2006 - "Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 09/28/2020 - "Then, we proposed a ratiometric photoacoustic (PA) probe, which can be tailored by cathepsin E and self-assembled into nanofibers in situ inside pancreatic cancer cells. " 10/01/2019 - "Cathepsin E expression and activity: Role in the detection and treatment of pancreatic cancer." 07/01/2013 - "Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection." 05/10/2013 - "Pancreatic cancer-associated Cathepsin E as a drug activator." 09/01/2012 - "Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models."

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Biomarkers (Surrogate Marker)
3.	Proteins (Proteins, Gene)
4.	Claudin-4
5.	Galectin 3 (LGALS3)
6.	Caspases
7.	Pepsinogens
8.	Cathepsin B
9.	Polo-Like Kinase 1
10.	Survivin

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Gastrectomy