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N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)

An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Also Known As:
Arylsulfatase B; Arylsulfatase B1; Arylsulfatase B2; N-Acetylgalactosamine 4-Sulfatase; N-Acetylgalactosamine-4-sulfate Sulfatase; N-Acetylgalactosamine-4-sulphate Sulphatase; 4-Sulfatase, N-Acetylgalactosamine; B, Arylsulfatase; B1, Arylsulfatase; B2, Arylsulfatase; N Acetylgalactosamine 4 Sulfatase; N Acetylgalactosamine 4 sulfate Sulfatase; N Acetylgalactosamine 4 sulphate Sulphatase; Sulfatase, N-Acetylgalactosamine-4-sulfate; Sulphatase, N-Acetylgalactosamine-4-sulphate; N-Acetyl-D-Galactosamine-4-sulfate 4-sulfohydrolase
Networked: 163 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hopwood, John J: 15 articles (03/2015 - 04/2002)
2. Giugliani, Roberto: 11 articles (08/2014 - 01/2003)
3. Harmatz, Paul: 11 articles (08/2014 - 05/2004)
4. Scarpa, Maurizio: 7 articles (03/2015 - 04/2006)
5. Tobacman, Joanne K: 6 articles (08/2015 - 06/2003)
6. Bhattacharyya, Sumit: 6 articles (08/2015 - 05/2007)
7. Ketteridge, David: 6 articles (08/2014 - 06/2005)
8. Auricchio, Alberto: 5 articles (03/2015 - 01/2008)
9. Guffon, Nathalie: 5 articles (08/2014 - 04/2006)
10. Brooks, Doug A: 5 articles (05/2012 - 04/2002)

Related Diseases

1. Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
2. Mucopolysaccharidoses
3. Vitamin A Deficiency
4. Papilledema
5. Lysosomal Storage Diseases (Lysosomal Storage Disease)

Related Drugs and Biologics

1. Neutralizing Antibodies
2. galsulfase
3. N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)
4. Cerebroside-Sulfatase (Arylsulfatase A)
5. Eosinophil Cationic Protein
6. Arylsulfatases
7. Dermatan Sulfate
8. Glycosaminoglycans
9. Enzymes
10. Chondroitin Sulfates (Chondroitin Sulfate)

Related Therapies and Procedures

1. Enzyme Replacement Therapy
2. Drug Therapy (Chemotherapy)