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Protein Isoforms (Isoforms)

Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
Also Known As:
Isoforms; Protein Splice Variants; Isoforms, Protein; Variants, Protein Splice; Splice Variants, Protein
Networked: 9625 relevant articles (144 outcomes, 1279 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Supuran, Claudiu T: 133 articles (01/2016 - 08/2003)
2. Scozzafava, Andrea: 52 articles (12/2015 - 08/2003)
3. Vullo, Daniela: 36 articles (12/2015 - 08/2003)
4. Carta, Fabrizio: 26 articles (12/2015 - 10/2009)
5. Ceruso, Mariangela: 21 articles (01/2016 - 03/2014)
6. Winum, Jean-Yves: 21 articles (07/2015 - 09/2006)
7. Innocenti, Alessio: 20 articles (05/2013 - 08/2006)
8. Keyomarsi, Khandan: 17 articles (08/2015 - 11/2002)
9. Bates, David O: 16 articles (08/2015 - 11/2004)
10. Maresca, Alfonso: 15 articles (04/2013 - 06/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Inflammation
3. Prostatic Neoplasms (Prostate Cancer)
4. Alzheimer Disease (Alzheimer's Disease)
05/01/2015 - "In this study, Western blots, enzyme-linked immunosorbent assay and histological approaches were used to assess the concentrations of Aβ, τ and JNK isoforms in postmortem brain tissue samples (10 Alzheimer disease and 10 control) and in CSF samples from 30 living patients with Alzheimer disease and 27 controls with neurologic disease excluding Alzheimer disease. "
01/01/2008 - "In this study, the expression of the mature neuronal marker high molecular weight microtubule-associated protein (MAP) isoforms MAP2a and b was found to be dramatically decreased in Alzheimer disease dentate gyrus, as determined by immunohistochemistry and in situ hybridization. "
07/01/1989 - "These studies suggest that (i) the amino acid sequences of some isoforms of tau peptide might be different from that predicted from cDNAs, (ii) a tau peptide that is absent in the predicted sequences is present in PHF in Alzheimer disease, and (iii) tau in PHF is abnormally phosphorylated."
10/01/2015 - "Among the different PDE4 isoforms, in the last few years PDE4D has been hogging the limelight due to accumulating evidence for its crucial role in cognitive processes, which makes this enzyme a promising target for therapeutic interventions in a variety of pathological conditions characterized by memory impairment, such as Alzheimer's disease. "
06/15/2015 - "RAGE signaling has been reported involved in the onset and development of Alzheimer's disease (AD) and the roles of RAGE AS isoforms have not yet been fully illustrated in AD pathogenesis. "
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3. Nitric Oxide (Nitrogen Monoxide)
4. Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
5. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
6. Messenger RNA (mRNA)
7. Nitric Oxide Synthase (NO Synthase)
8. Proteins (Proteins, Gene)
9. Protein Kinase C
10. Carbonic Anhydrases (Carbonic Anhydrase)

Related Therapies and Procedures

1. Intramuscular Injections
2. Drug Therapy (Chemotherapy)
3. Lasers (Laser)
4. Homologous Transplantation (Allograft)
5. Plasma Exchange