Neurocysticercosis

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430 relevant articles (38 outcomes, 52 trials/studies) found for this Disease

Description: Infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus TAENIA (primarily T. solium in humans). Lesions formed by the organism are referred to as cysticerci. The infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. SEIZURES represent the most common clinical manifestation although focal neurologic deficits may occur. (From Joynt, Clinical Neurology, 1998, Ch27, pp46-50)

Also Known As:

Brain Cysticercosis; Neurocysticercoses; Central Nervous System Cysticercosis; Cysticercosis, Brain; Cysticercosis, Central Nervous System

Relationship Network

Disease Context: Research Results

Parasitic Diseases: 528

Helminthiasis: 264

Cestode Infections: 106

Taeniasis: 141

Cysticercosis: 610

Neurocysticercosis: 430

Central Nervous System Parasitic Infections

Central Nervous System Helminthiasis

Neurocysticercosis: 430

Nervous System Diseases: 3414

Central Nervous System Diseases: 930

Central Nervous System Infections: 238

Central Nervous System Parasitic Infections

Central Nervous System Helminthiasis

Neurocysticercosis: 430

Related Diseases

1.	Seizures (Seizure)
2.	Cysticercosis
3.	Cysts
4.	Infection
5.	Intracranial Hypertension

Experts

1.	Teale, Judy M: 7 articles (06/2008 - 03/2003)
2.	Cysticercosis Working Group in Peru: 6 articles (03/2007 - 11/2000)
3.	Vaz, A J: 6 articles (06/2002 - 01/2000)
4.	Garcia, Hector H: 5 articles (06/2008 - 10/2005)
5.	Livramento, J A: 5 articles (11/2001 - 01/2000)
6.	Alvarez, Jorge I: 4 articles (06/2008 - 07/2007)
7.	Harrison, L J S: 4 articles (06/2008 - 04/2002)
8.	Parkhouse, R M E: 4 articles (06/2008 - 04/2002)
9.	Vaz, Adelaide J: 4 articles (08/2006 - 06/2002)
10.	Bueno, E C: 4 articles (11/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurocysticercosis:

1.	Albendazole (Albenza)FDA Link 11/01/1989 - "We conclude that albendazole administered according to the 3-day therapeutic scheme proposed above is as highly effective for the treatment of parenchymal brain cysticercosis as the 30-day scheme." 10/01/1988 - "Our results indicated that a short course of albendazole is highly effective for treatment of neurocysticercosis." 04/01/1987 - "We conclude that albendazole is highly effective for the treatment of parenchymal brain cysticercosis" 08/01/2002 - "AIMS: Albendazole (ABZ) is effective in the treatment of neurocysticercosis" 11/01/1995 - "Reports from Mexico suggest that albendazole is effective in the treatment of neurocysticercosis" Order ALL the reference details at left...
2.	Praziquantel (Biltricide)FDA Link 01/01/1988 - "A prospective open therapeutic study on volunteers with active neurocysticercosis using pyrazinoisoquinolone (Praziquantel) has shown that it is a safe and effective drug" 07/01/1999 - "OBJECTIVE: Fifteen-day praziquantel therapy for parenchymal neurocysticercosis has been shown to be effective" 06/01/1997 - "A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis" 01/01/1990 - "Standard therapeutic regimens of praziquantel for neurocysticercosis use daily doses of 50 mg/kg for 15-21 days, with prolonged remission being achieved in 60-80% patients" 04/01/1989 - "Remission of a case of intraparenchymal neurocysticercosis following treatment with praziquantel]" Order ALL the reference details at left...
3.	AntigensIBA 07/01/1998 - "The use of antigen-detection tests specific for viable metacestodes has immediate utility in the clinical context, not only providing important information on the viability of the parasites but also leading to an improved understanding of the pathogenesis of neurocysticercosis before and after drug treatment." 03/01/2007 - "The efficacy of whole parasite and vesicular fluid antigen extracts from Taenia solium and Taenia crassiceps cysticerci for immunodiagnosis of neurocysticercosis was evaluated using ELISA on cerebrospinal fluid samples" 06/01/2008 - "Utility of cysticercus fasciolaris antigen in Dot ELISA for the diagnosis of neurocysticercosis." 04/01/2008 - "Evaluation of lower molecular mass (20-24 kDa) Taenia solium cysticercus antigen fraction by ELISA and dot blot for the serodiagnosis of neurocysticercosis in children." 09/01/2007 - "Application of Taenia saginata metacestodes as an alternative antigen for the serological diagnosis of human neurocysticercosis." Order ALL the reference details at left...
4.	Glycoproteins (Glycoprotein)IBA 03/01/2003 - "Similar diagnostic performance for neurocysticercosis of three glycoprotein preparations from Taenia solium metacestodes." 06/01/2002 - "The aim of this work was to evaluate a Taenia solium glycoproteins-based enzyme-linked immunoelectrotransfer blot assay in children with neurocysticercosis" 05/01/2000 - "The Lens culinaris-binding glycoproteins from this parasite have been shown to be ideal targets for the development of a highly specific immunoassay for the diagnosis of neurocysticercosis" 08/01/1999 - "Diagnosis of neurocysticercosis is performed by Western blotting with an enriched fraction of glycoproteins (LLGP)" 08/01/1994 - "In this paper we report the purification of GP24, one of the seven specific and highly antigenic Taenia solium glycoproteins previously identified by Western blot (WB) with serum, cerebrospinal fluid (CSF) and saliva samples from patients with neurocysticercosis (NC)" Order ALL the reference details at left...
5.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2008 - "The diagnosis of neurocysticercosis was made, and the patient improved on dexamethasone and a short course of vermicide, to be discharged a week later" 01/01/1994 - "The treatment of acute neurocysticercosis was made with dexamethasone" 07/01/2003 - "Efficacy of albendazole and short-course dexamethasone treatment in children with 1 or 2 ring-enhancing lesions of neurocysticercosis: a randomized controlled trial." 02/01/1997 - "Therapy for neurocysticercosis: pharmacokinetic interaction of albendazole sulfoxide with dexamethasone." 12/01/1990 - "Twenty seven patients with neurocysticercosis were treated with praziquantel in progressive doses reaching 50 mg/kg/day associated with dexamethasone for 21 days" Order ALL the reference details at left...
6.	lentil lectinIBA 01/01/2002 - "Detection of seven specific bands by immunoblot (IB) using glycoproteins (GPs) purified by lentil-lectin affinity chromatography has been the gold-standard for neurocysticercosis (NCC) serodiagnosis since 1989" 03/01/2005 - "The gold standard serodiagnostic assay for cysticercosis and neurocysticercosis, diseases caused by the metacestode of Taenia solium, uses lentil lectin-purified glycoprotein (LLGP) in a Western blot assay" Order ALL the reference details at left...
7.	AntibodiesIBA 09/01/2004 - "The aim of the present study was to standardize and evaluate dot-Enzyme linked immunosorbent assay (Dot-ELISA), a simple and rapid test for the detection of cysticercus antibodies in the serum for the diagnosis of neurocysticercosis (NCC)" 09/01/1997 - "The study was carried out using immunoblotting to detect antibodies in cerebrospinal fluid (CSF) from patients with neurocysticercosis" 01/01/2006 - "Diagnosis of neurocysticercosis (NCC) is usually based on neuroimaging and/or immunological analysis of cerebrospinal fluid (CSF) and/or serum samples for detection of specific antibodies against T" 10/01/2005 - "crassiceps cysticerci may be useful for detecting specific antibodies in sera from patients with neurocysticercosis." 07/01/2005 - "These MAbs and antibodies from cerebrospinal fluid (CSF) as well as serum samples from patients with neurocysticercosis (NC) reacted with 18- and 14-kDa T" Order ALL the reference details at left...
8.	AnthelminticsIBA 05/01/1997 - "This article reviews briefly the pharmacology of these 5 drugs, and then discusses current issues in the use of anthelmintics in the treatment and/or control of soil-transmitted nematode infections, filariasis, onchocerciasis, schistosomiasis (and other trematode infections), neurocysticercosis and hydatidosis" 10/01/1996 - "Since the anthelmintics praziquantel and albendazole were shown to be effective in parenchymal brain cysticercosis, these drugs have been considered potentially useful in patients with intramedullary cysticercosis" Order ALL the reference details at left...
9.	Immunoglobulin G (IgG)IBA 01/01/1988 - "This study compares the results of cysticercus-specific IgG antibody levels, as measured by enzyme-linked immunosorbent assay (ELISA), with brain CT findings in suspected neurocysticercosis and to assess the clinical significance of ELISA" 11/15/2005 - "In the neurocysticercosis group, intrathecal synthesis of IgG was detected in 12 (75%) and 5 (31.2%) patients by quantitative and qualitative methods, respectively" 11/15/2005 - "We studied IgG concentration in cerebrospinal fluid in 16 patients with neurocysticercosis comparing with a control group of 19 patients to verify which pattern of increase in IgG concentration in cerebrospinal fluid occurs in neurocysticercosis" 11/15/2005 - "An increase in immunoglobulin G (IgG) concentration in the cerebrospinal fluid of patients with neurocysticercosis has been described but the reasons for this finding are unknown" 11/15/2005 - "Evaluation of intrathecal synthesis of IgG in neurocysticercosis." Order ALL the reference details at left...
10.	CytokinesIBA 06/01/2002 - "In this study, a histological and immunohistochemical analysis of five brain specimens from patients with neurocysticercosis revealed a proinflammatory activity reflected by an apparently altered blood-brain barrier permeability, secretion of pro-inflammatory cytokines, and up-regulation of molecules associated with antigen presentation" 09/30/2008 - "In neurocysticercosis, CSF cytokines correlate with cerebral blood flow velocities." 06/01/2001 - "Cellular immune response and Th1/Th2 cytokines in human neurocysticercosis: lack of immune suppression." 08/01/2006 - "Thus, proinflammatory cytokines are not responsible for the seizures in the rodent model of neurocysticercosis." 09/01/2005 - "An immune-inflammatory profile that underlies neurocysticercosis presentation was determined in 45 cerebral spinal fluid (CSF), from clinical and radiologically characterized neurocysticercosis patients, measuring specific IgG subclasses and cytokines" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/04/2006 - "STUDY SELECTION: Randomized trials of cysticidal drug therapy for neurocysticercosis that met predefined criteria designed to allow characterization of the disease and objective evaluation of therapy" 08/01/1992 - "This hypothesis raises important questions in assessing the role of chemotherapy in the management of neurocysticercosis as well as in evaluation of clinical trials, most of which have been uncontrolled." 03/01/1997 - "Chemotherapy for neurocysticercosis was born logically because of the scant success of surgery, which is generally palliative, not curative" 01/01/2006 - "Role of chemotherapy of taeniasis in prevention of neurocysticercosis." Order ALL the reference details at left...
2.	Aftercare (After-Treatment) 04/01/2005 - "In the following report, the CT and MR characteristics of this rare form of neurocysticercosis both before and after treatment are described, and the current issues surrounding management are briefly discussed." 03/01/2003 - "Follow-up of neurocysticercosis patients after treatment using an antigen detection ELISA." 03/01/1995 - "In a prospective study, 17 Brazilian patients with parenchymatous neurocysticercosis were monitored for a period of 12 months after treatment with praziquantel" 03/01/1995 - "Clinical and immunologic follow-up study of patients with neurocysticercosis after treatment with praziquantel." 05/15/2003 - "Prolonged perilesional edema after treatment of parenchymal neurocysticercosis: methotrexate as a corticosteroid-sparing agent." Order ALL the reference details at left...
3.	Ventriculoperitoneal Shunt 07/01/2008 - "Reversible parkinsonism following ventriculoperitoneal shunt in a patient with obstructive hydrocephalus secondary to intraventricular neurocysticercosis." 06/01/2000 - "Report of a girl with the epileptic, hydrocephalic and encephalitic form of neurocysticercosis, diagnosed by cerebrospinal fluid and computed tomography exams, during her second year of life and an evolution with multiple types of seizures, prolonged periods of intracranial hypertension due to obstruction in the ventriculoperitoneal shunt, psychomotor regression and blindness until she was 10 years old, when the Lennox-Gastaut syndrome was diagnosed" 07/01/1991 - "The Authors report a case of neurocysticercosis treated with praziquantel and ventriculoperitoneal shunt" Order ALL the reference details at left...
4.	Nursing Care 01/01/1970 - "Nursing care of patients with neurocysticercosis]" 09/01/1969 - "Nursing care of paiients with neurocysticercosis]" Order ALL the reference details at left...
5.	Spinal Anesthesia 08/01/2003 - "This report describes a patient who developed a positional headache after spinal anesthesia that was due to neurocysticercosis, a parasitic central nervous system infestation caused by the tapeworm Taenia solium." 10/01/1996 - "Assessment of antimycobacterial antibody in the neurologic control CSF samples of pyogenic meningitis [n = 10], cryptococcal meningitis [6], neurocysticercosis [28], neurosyphilis [8], viral meningoencephalitis [8], carcinomatous meningitis [8], iatrogenic meningitis [6], and nonneurological control CSF samples from patients undergoing spinal anesthesia [20] revealed the presence of antibody in the CSF of 2 of the 10 pyogenic meningitis and 5 of the 28 neurocysticercosis cases" Order ALL the reference details at left...

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