1-Octanol (1 Octanol)

A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Also Known As:

Networked: 39 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hallett, Mark: 4 articles (04/2016 - 10/2011)
2.	Haubenberger, Dietrich: 4 articles (04/2016 - 10/2011)
3.	Nahab, Fatta B: 3 articles (01/2014 - 10/2011)
4.	Buchwald, Peter: 2 articles (04/2016 - 10/2011)
5.	Potti, Gopal: 2 articles (04/2016 - 10/2011)
6.	Starling, Judith: 2 articles (04/2016 - 10/2011)
7.	Voller, Bernhard: 2 articles (04/2016 - 01/2014)
8.	Dong, Chuanhui: 2 articles (07/2012 - 10/2011)
9.	Bushara, K O: 2 articles (06/2004 - 01/2004)
10.	Hallett, M: 2 articles (06/2004 - 01/2004)

Related Diseases

1.	Essential Tremor (Essential Tremors) 04/01/2016 - "Recently, 1-octanol has been shown to have efficacy in treating patients with essential tremor (ET). " 06/22/2004 - "Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. " 06/22/2004 - "Open-label dose-escalation study of oral 1-octanol in patients with essential tremor." 01/13/2004 - "Pilot trial of 1-octanol in essential tremor." 10/01/2011 - "An open-label, single-dose, crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremor."
2.	Tremor (Tremors) 10/01/2011 - "Two previous studies of a longer chain alcohol, 1-octanol, have demonstrated longer duration tremor-suppressive effects without the occurrence of intoxication. " 01/13/2004 - "1-Octanol significantly decreased tremor amplitude for up to 90 minutes. " 04/01/2016 - "The primary metabolite of 1-octanol is octanoic acid (OA), which is now thought to be the active substance that mediates tremor suppression. " 01/01/2014 - "While ethanol is reported to profoundly decrease tremor severity in the majority of patients with ET, preclinical experience suggests that long-chain alcohols such as 1-octanol might lead to a comparable tremor reduction without ethanol's typical side effects of sedation and intoxication. " 07/01/2012 - "Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. "
3.	Wounds and Injuries (Trauma) 05/06/2023 - "The release studies were performed to simulate the wound conditions: 1-octanol to mimic the lipophilic domains of biological tissues (where the First Order kinetic was observed) and citrate buffer pH 5.5 according to the inflammatory wound exudate (where the Korsmeyer-Peppas kinetic was followed). "
4.	Stupor 02/01/2005 - "Toxic potency [log(IGC50(-1))] for most of these chemicals was in excess of baseline narcosis as quantified by the 1-octanol/water partition coefficient (log K(ow)). " 11/01/2004 - "The quantitative structure-activity relationships (QSAR) approach showed that all substances act by nonpolar narcosis; thus, the higher the n-octanol/water partitioning coefficient (log Kow) of the substances, the higher is their toxicity. " 11/01/1993 - "Log 1-octanol/water partition coefficients (log Kow) along with previously developed quantitative structure-activity relationships (QSARs) for both the non-polar narcosis and polar narcosis mechanism of action were used to predict relative toxicity. " 01/01/2008 - "The aim of this work was to develop a high-quality 1-octanol/water partition coefficient-dependent (log P) baseline quantitative structure-activity relationship (QSAR) for the toxicity (log IGC(50)(-1)) of classic non-polar narcotics to Tetrahymena pyriformis, and subsequently use this model to define the domain of applicability for baseline narcosis. "
5.	Neoplasms (Cancer) 10/01/2011 - "Can selective tumor cell killing be predicted based on n-octanol/water distribution coefficients?" 02/01/2005 - "Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropirydine N-oxide compounds in radiotherapy of cancer. " 11/01/1993 - "Passage of the fluorescent dye, and hence intercellular communication, was inhibited both by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) and by 1-octanol, known uncouplers of gap junctions in a variety of invertebrate and vertebrate cell types. " 05/10/2022 - "In this paper, we focus on the solvation of several potential chlorin PSs in the 1-octanol/phosphate saline buffer biphasic system, their interaction with non-ionic surfactant Tween 80 and photoinactivation of cancer cells. "

Related Drugs and Biologics

1.	Buffers
2.	Citric Acid (Citrate)
3.	Alcohols
4.	Phosphates (Orthophosphate)
5.	Ethanol (Ethyl Alcohol)
6.	1-hexanol (n-hexanol)
7.	Esters
8.	octanoic acid (caprylic acid)
9.	Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)
10.	1-Butanol (n Butanol)

Related Therapies and Procedures

1.	Radiotherapy
2.	Intravenous Injections
3.	Anesthesia