1-Octanol (1 Octanol)

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21 relevant articles (0 outcomes, 2 trials/studies) found for this Bio-Agent

Description: A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Also Known As:

1 Octanol; n-Octyl Alcohol; Alcohol, n-Octyl; n Octanol; n Octyl Alcohol; n-Octanol

Bio-Agent Context: Research Results

Organic Chemicals: 40

Experts

1.	Bushara, K O: 2 articles (06/2004 - 01/2004)
2.	Hallett, M: 2 articles (06/2004 - 01/2004)
3.	Reich, M: 1 article (06/2004)
4.	Shill, H A: 1 article (06/2004)
5.	Mari, Z: 1 article (06/2004)
6.	Goldstein, S R: 1 article (01/2004)
7.	Burstein, A H: 1 article (01/2004)
8.	Grimes, G J: 1 article (01/2004)

Related Diseases

1.	Essential Tremor (Essential Tremors) 06/22/2004 - "Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study" 06/22/2004 - "Open-label dose-escalation study of oral 1-octanol in patients with essential tremor." 01/13/2004 - "Pilot trial of 1-octanol in essential tremor." 01/13/2004 - "1-Octanol (an 8-C alcohol currently used as a food-flavoring agent) is known to inhibit tremor in essential tremor (ET) animal models at a much lower dose than ethyl alcohol" 01/01/2008 - "Several new drugs, including 1-octanol, sodium oxybate, dimethoxymethyl-diphenyl-barbituric acid (T-2000) and carisbamate, are currently under investigation for the treatment of essential tremor." Order ALL the reference details at left...
2.	Stupor 02/01/2005 - "Toxic potency [log(IGC50(-1))] for most of these chemicals was in excess of baseline narcosis as quantified by the 1-octanol/water partition coefficient (log K(ow))" 11/01/2004 - "The quantitative structure-activity relationships (QSAR) approach showed that all substances act by nonpolar narcosis; thus, the higher the n-octanol/water partitioning coefficient (log Kow) of the substances, the higher is their toxicity" 11/01/1993 - "Log 1-octanol/water partition coefficients (log Kow) along with previously developed quantitative structure-activity relationships (QSARs) for both the non-polar narcosis and polar narcosis mechanism of action were used to predict relative toxicity" Order ALL the reference details at left...
3.	Phototoxic Dermatitis (Phototoxicity) 11/01/2005 - "While some differences were noted in the n-octanol/pH 7.4 buffer partition coefficient, log D(7.4), among the compounds, log D(7.4) did not critically influence the cellular uptake or phototoxicity" 02/01/1996 - "The QSAR between phototoxicity and the log of the partition coefficients (phosphate-buffered saline and n-octanol) gave a parabola with optimal partition values corresponding to the adjacent sulfonated ZnPcS2." Order ALL the reference details at left...
4.	Neoplasms (Cancer) 02/01/2005 - "Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropirydine N-oxide compounds in radiotherapy of cancer" 11/01/1993 - "Passage of the fluorescent dye, and hence intercellular communication, was inhibited both by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) and by 1-octanol, known uncouplers of gap junctions in a variety of invertebrate and vertebrate cell types" Order ALL the reference details at left...
5.	Adenocarcinoma 10/01/1999 - "This approach is based on the use of two models: the determination of coefficient of distribution between n-octanol and a phosphate buffer, pH 7.4, and the determination of the cytotoxic effect on the culture of CaOv ovarian adenocarcinoma cells." 04/01/1995 - "A2780 and COLO-316 ovarian adenocarcinoma cell lines were exposed to 1.0 mM 1-octanol for 12 hr in order to evaluate the potential effects of inhibition of gap junction-mediated intercellular communication (GJIC) on cellular responses to the chemotherapeutic drug melphalan" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Ethanol (Ethyl Alcohol)
2.	Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)
3.	1-Butanol (n Butanol)
4.	2,4-Dinitrophenol (2,4 Dinitrophenol)
5.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
6.	Urethane (Ethyl Carbamate)
7.	Sodium Oxybate (gamma Hydroxybutyrate)
8.	Oxygen
9.	Melphalan (Alkeran)
10.	Flavoring Agents

Related Therapies and Procedures

1.	Anesthesia

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