|1.||Haubenberger, Dietrich: 3 articles (01/2014 - 10/2011)|
|2.||Hallett, Mark: 3 articles (01/2014 - 10/2011)|
|3.||Nahab, Fatta B: 3 articles (01/2014 - 10/2011)|
|4.||Dong, Chuanhui: 2 articles (07/2012 - 10/2011)|
|5.||Hallett, M: 2 articles (06/2004 - 01/2004)|
|6.||Bushara, K O: 2 articles (06/2004 - 01/2004)|
|7.||Lathia, Justin D: 1 article (10/2015)|
|8.||Sinyuk, Maksim: 1 article (10/2015)|
|9.||Saunthararajah, Yogen: 1 article (10/2015)|
|10.||Huang, Alex Y: 1 article (10/2015)|
|1.||Essential Tremor (Essential Tremors)
06/22/2004 - "Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. "
06/22/2004 - "Open-label dose-escalation study of oral 1-octanol in patients with essential tremor."
01/13/2004 - "Pilot trial of 1-octanol in essential tremor."
10/01/2011 - "An open-label, single-dose, crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremor."
01/13/2004 - "1-Octanol (an 8-C alcohol currently used as a food-flavoring agent) is known to inhibit tremor in essential tremor (ET) animal models at a much lower dose than ethyl alcohol. "
10/01/2011 - "Two previous studies of a longer chain alcohol, 1-octanol, have demonstrated longer duration tremor-suppressive effects without the occurrence of intoxication. "
01/13/2004 - "1-Octanol significantly decreased tremor amplitude for up to 90 minutes. "
01/01/2014 - "While ethanol is reported to profoundly decrease tremor severity in the majority of patients with ET, preclinical experience suggests that long-chain alcohols such as 1-octanol might lead to a comparable tremor reduction without ethanol's typical side effects of sedation and intoxication. "
07/01/2012 - "Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. "
07/01/2012 - "We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. "
02/01/2005 - "Toxic potency [log(IGC50(-1))] for most of these chemicals was in excess of baseline narcosis as quantified by the 1-octanol/water partition coefficient (log K(ow)). "
11/01/2004 - "The quantitative structure-activity relationships (QSAR) approach showed that all substances act by nonpolar narcosis; thus, the higher the n-octanol/water partitioning coefficient (log Kow) of the substances, the higher is their toxicity. "
11/01/1993 - "Log 1-octanol/water partition coefficients (log Kow) along with previously developed quantitative structure-activity relationships (QSARs) for both the non-polar narcosis and polar narcosis mechanism of action were used to predict relative toxicity. "
01/01/2008 - "The aim of this work was to develop a high-quality 1-octanol/water partition coefficient-dependent (log P) baseline quantitative structure-activity relationship (QSAR) for the toxicity (log IGC(50)(-1)) of classic non-polar narcotics to Tetrahymena pyriformis, and subsequently use this model to define the domain of applicability for baseline narcosis. "
10/01/2011 - "Can selective tumor cell killing be predicted based on n-octanol/water distribution coefficients?"
02/01/2005 - "Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropirydine N-oxide compounds in radiotherapy of cancer. "
11/01/1993 - "Passage of the fluorescent dye, and hence intercellular communication, was inhibited both by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) and by 1-octanol, known uncouplers of gap junctions in a variety of invertebrate and vertebrate cell types. "
|5.||Phototoxic Dermatitis (Phototoxicity)
11/01/2005 - "While some differences were noted in the n-octanol/pH 7.4 buffer partition coefficient, log D(7.4), among the compounds, log D(7.4) did not critically influence the cellular uptake or phototoxicity. "
02/01/1996 - "The QSAR between phototoxicity and the log of the partition coefficients (phosphate-buffered saline and n-octanol) gave a parabola with optimal partition values corresponding to the adjacent sulfonated ZnPcS2."
|2.||Ethanol (Ethyl Alcohol)
|3.||Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)
|4.||2,4-Dinitrophenol (2,4 Dinitrophenol)
|5.||N-Methyl-D-Aspartate Receptors (NMDA Receptors)
|6.||Urethane (Ethyl Carbamate)
|7.||Sodium Oxybate (gamma Hydroxybutyrate)
|8.||Narcotics (Narcotic Analgesics)