Cocaine-Related Disorders (Cocaine Addiction)

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1847 relevant articles (142 outcomes, 399 trials/studies) found for this Disease

Description: Disorders related or resulting from use of cocaine.

Also Known As:

Cocaine Addiction; Addiction, Cocaine; Dependence, Cocaine; Cocaine Abuse; Cocaine Users; Abuse, Cocaine; Cocaine Related Disorders; Cocaine User; Cocaine-Related Disorder; Dependences, Cocaine; Disorder, Cocaine-Related; Disorders, Cocaine-Related; User, Cocaine; Users, Cocaine; Cocaine Dependence

Relationship Network

Disease Context: Research Results

Disorders of Environmental Origin

Substance-Related Disorders: 5511

Cocaine-Related Disorders: 1847

Mental Disorders: 1709

Substance-Related Disorders: 5511

Cocaine-Related Disorders: 1847

Related Diseases

1.	Cocaine-Related Disorders (Cocaine Addiction)
2.	Schizophrenia (Dementia Praecox)
3.	Alcoholism (Alcohol Abuse)
4.	Substance-Related Disorders (Drug Abuse)
5.	Bipolar Disorder (Mania)

Experts

1.	Elkashef, Ahmed: 12 articles (01/2008 - 06/2003)
2.	Kampman, Kyle M: 9 articles (08/2008 - 03/2002)
3.	O'Brien, Charles P: 9 articles (08/2008 - 03/2002)
4.	Farrell, M: 8 articles (01/2008 - 01/2000)
5.	Poling, James: 7 articles (10/2007 - 01/2005)
6.	Lima, M S: 7 articles (01/2003 - 01/2000)
7.	Kosten, Thomas R: 6 articles (10/2007 - 08/2003)
8.	Sofuoglu, Mehmet: 6 articles (10/2007 - 08/2004)
9.	Preston, Kenzie L: 6 articles (03/2007 - 01/2002)
10.	Soares, B G: 6 articles (01/2003 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cocaine-Related Disorders:

1.	Cocaine (Cocaine HCl)IBA 10/01/1997 - "Rates of complete abstinence during the 6-month study period were higher in STND than RP, whereas RP was more effective in limiting the extent of cocaine use in those who used during Months 1-3. Matching analyses indicated patients who failed to achieve remission from cocaine dependence during IOP and those with a commitment to absolute abstinence did better in RP than in STND, whereas patients with other abstinence goals did better in STND than RP" 06/01/2005 - "Self reported cocaine use, cocaine craving, and global impression scores showed moderate improvement in both groups, with a significantly greater reduction in cocaine craving (p < 0.05) and self-rated severity of cocaine dependence (p < 0.05) in the placebo group" 10/01/2004 - "Expanding research on reward-related brain circuitry, which is acutely activated and chronically dysregulated by cocaine, has helped reveal the neurobiological features of cocaine dependence and is guiding pharmacologic strategies that have significant potential to improve clinical outcome" 01/01/2004 - "Although medication adherence (based on urine specimens) was not independently associated with a significant reduction in recidivism risk, the interaction between cocaine use and medication adherence was significant, revealing a disproportionate impact of medication adherence specific to cocaine users" 08/01/2003 - "While the improvements were not significant between groups, within-group analysis revealed that the treatment group reduced self-reported cocaine use (P = 0.02), reduced criminal activity (P = 0.04), reduced cravings (P < 0.01) and reduced severity of cocaine dependence (P < 0.01) with no within-group improvements found in the placebo group" Order ALL the reference details at left...
2.	Methadone (Dolophine)FDA LinkGeneric 08/01/2006 - "Similarly, the impact of cocaine abuse on psychiatric and social function in subjects already affected by opioid addiction is still poorly understood and further studies are necessary to investigate this specific area that could profoundly affect methadone maintenance treatment" 01/01/2003 - "There were no significant differences between interventions, and in trials where participants had primary cocaine dependence or had additional diagnosis of opioid dependence and/or were in methadone maintenance treatment" 01/01/2001 - "There were no significant differences in trials where participants had primary cocaine dependence or had additional diagnosis of opioid dependence and/or were in methadone maintenance treatment" 05/01/1995 - "We conducted a 6-week, single-blind study of acupuncture for cocaine dependence in methadone-maintained patients (N = 40) for the purpose of identifying an appropriate needle puncture control for use in future large-scale clinical trials" 01/01/1994 - "The findings suggest that specialized cocaine abuse treatment can benefit methadone patients; intake to the study is continuing." Order ALL the reference details at left...
3.	Dopamine (Intropin)FDA LinkGeneric 06/14/2006 - "Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction." 02/01/1995 - "Agents that interact with specific subcomponents of the dopamine system or its connections offer promise for the development of successful agents to treat cocaine abuse and craving in humans." 01/11/2008 - "This performance pattern is consistent with other laboratory studies of long-term cocaine users that demonstrated that established learning interfered with new learning on incremental learning tasks, relative to healthy controls, and may reflect altered dopamine transmission in the basal ganglia of long-term cocaine users." 09/01/2005 - "Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence." 05/13/2003 - "These studies indicated that ACh and dopamine acted convergently but oppositely on the NAc circuit and that cholinergic cell ablation enhanced long-lasting behavioral changes of cocaine addiction" Order ALL the reference details at left...
4.	Disulfiram (Antabuse)FDA Link 04/01/2004 - "Converging evidence suggests that disulfiram is a promising treatment for cocaine dependence" 07/01/2008 - "BACKGROUND: Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns" 07/01/2008 - "The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice." 08/01/2004 - "The objective of this study is to evaluate differential response to disulfiram treatment of cocaine dependence by sex" 02/01/2000 - "Recent studies have evaluated disulfiram as a treatment for individuals with comorbid alcohol and cocaine abuse" Order ALL the reference details at left...
5.	Desipramine (Pertofrane)FDA LinkGeneric 01/01/1984 - "Desipramine was compared with a placebo under double-blind conditions to determine if it is effective treatment for withdrawal from cocaine dependence" 12/01/1991 - "Using the technique of meta-analysis, we compared and combined the data from six studies to examine the efficacy of desipramine as an adjunctive treatment approach for cocaine addiction" 03/01/2003 - "This finding supports previous reports of a possible role for desipramine in cocaine abuse treatment." 09/01/2000 - "Conversely, uptake inhibitors, such as the tricyclic antidepressant, desipramine, and the drug of abuse, cocaine, inhibit noradrenergic differentiation in both tissues" 03/01/1994 - "Desipramine treatment for cocaine dependence" Order ALL the reference details at left...
6.	olanzapine (Zyprexa)FDA Link 06/05/2003 - "CONCLUSIONS: The results of this trial do not support the usefulness of olanzapine for the treatment of cocaine dependence" 06/05/2003 - "A pilot trial of olanzapine for the treatment of cocaine dependence." 03/01/2006 - "The neuropharmacological profile of the atypical antipsychotic, olanzapine, is consistent with a potentially useful medication for cocaine abuse" 02/01/2006 - "The efficacy of olanzapine for decreasing cue-elicited craving in individuals with schizophrenia and cocaine dependence: a preliminary report." 07/01/2007 - "The data suggest some potential for the utility of olanzapine for the treatment of cocaine dependence in individuals with schizophrenia." Order ALL the reference details at left...
7.	gabapentin (Neurontin)FDA LinkGeneric 01/01/2001 - "CONCLUSION: This pilot study indicates that gabapentin is safe and well tolerated and may be beneficial in the treatment of cocaine dependence" 10/01/2008 - "It has been proposed that gabapentin may be useful in the treatment of cocaine dependence" 02/28/2006 - "A randomized placebo-controlled trial of gabapentin for cocaine dependence." 02/01/2007 - "Together, the data indicate that gabapentin does not show promise as a treatment medication for cocaine dependence." 02/28/2006 - "CONCLUSIONS: When combined with weekly individual relapse-prevention therapy, gabapentin 1600 mg bid was no more effective than placebo in the treatment of cocaine dependence" Order ALL the reference details at left...
8.	Methylphenidate (Ritalin)FDA LinkGeneric 06/01/1983 - "An extreme case of cocaine dependence and marked improvement with methylphenidate treatment." 06/01/1998 - "This open trial was carried out to assess the efficacy of sustained-release methylphenidate for the treatment of cocaine abuse among individuals with ADHD" 06/01/1998 - "CONCLUSION: These preliminary data suggest that under close supervision, the combined intervention of sustained-release methylphenidate and relapse prevention therapy may be effective in treating individuals with both adult ADHD and cocaine dependence." 01/01/2005 - "An initial trial of methylphenidate in a population of adults with active cocaine dependence and ADHD indicates that this is the case" 08/01/2002 - "Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence." Order ALL the reference details at left...
9.	Amantadine (Aman)FDA LinkGeneric 01/01/2005 - "Amantadine, another medication with dopaminergic effects, may also be effective in cocaine users with high withdrawal severity" 05/01/2002 - "These results provide moderate support for further study of amantadine for the treatment of cocaine dependence." 05/01/2002 - "A screening trial of amantadine as a medication for cocaine dependence." 05/01/1996 - "Amantadine in the early treatment of cocaine dependence: a double-blind, placebo-controlled trial." 01/01/1988 - "A pilot trial of amantadine for ambulatory withdrawal for cocaine dependence." Order ALL the reference details at left...
10.	Dextroamphetamine (Dexedrine)FDA LinkGeneric 05/01/2002 - "Sustained release dextroamphetamine (15-30 mg but not 30-60 mg) improved retention in patients with cocaine dependence." 08/01/2003 - "Pilot randomized double blind placebo-controlled study of dexamphetamine for cocaine dependence." 08/01/2003 - "CONCLUSIONS: A definitive evaluation of the utility of dexamphetamine in the management of cocaine dependence is feasible and warranted." 08/01/2003 - "AIMS: To establish the feasibility of conducting a placebo-controlled clinical trial of dexamphetamine replacement therapy for cocaine dependence and to obtain preliminary data" 10/01/2001 - "Dextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trial." Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/1994 - "BACKGROUND: At present, there is no consensus regarding effective treatment for cocaine abuse or the most productive roles for the two major forms of treatment, pharmacotherapy and psychotherapy" 06/01/2002 - "Stress reduction, either alone or in combination with pharmacotherapies targeting the HPA axis may prove beneficial in reducing cravings and promoting abstinence in individuals seeking treatment for cocaine addiction." 01/01/2003 - "Given the difficulty of achieving sustained recovery, pharmacotherapy of opioid and cocaine addiction is more effective when combined with behavioral and psychosocial approaches" 02/01/2006 - "CONTEXT: No effective pharmacotherapies exist for cocaine dependence, although contingency management (CM) has demonstrated efficacy" 07/01/2001 - "Despite intensive medication development efforts, no effective pharmacotherapy for cocaine abuse has demonstrated efficacy for long-term use" Order ALL the reference details at left...
2.	Ear Acupuncture 01/01/2006 - "AUTHORS' CONCLUSIONS: There is currently no evidence that auricular acupuncture is effective for the treatment of cocaine dependence" 01/01/2006 - "OBJECTIVES: To determine whether auricular acupuncture is an effective treatment for cocaine dependence, and to investigate whether its effectiveness is influenced by the treatment regimen" 02/01/2003 - "Because auricular acupuncture (AA) has been shown to be effective as an adjunct treatment to cocaine dependence, we wished to test the feasibility and potential efficacy of this treatment in depressed adolescents with repetitive SIB" 01/01/2000 - "Auricular acupuncture is widely used for the treatment of cocaine addiction, and there is an urgent need to conduct controlled clinical research of this intervention" 04/01/2002 - "OBJECTIVE: To compare findings from two consecutive clinical trials of auricular acupuncture for cocaine addiction conducted at the same site in order to explore consistency of treatment effects" Order ALL the reference details at left...
3.	Self Administration (Administration, Self) 02/01/1997 - "In the present study, the behavioral effects of PTT were evaluated in two models of cocaine abuse: drug self-administration and drug discrimination" 10/01/2003 - "One approach for studying cocaine addiction has been to permit escalating patterns of self-administration (SA) by rats by prolonging daily drug availability" 07/01/2000 - "Alterations in neuroendocrine function associated with self-administration may be related to the development of cocaine dependence and could contribute to relapse in abstinent users." 01/01/1994 - "Use of rodent self-administration models to develop pharmacotherapies for cocaine abuse." 07/01/2008 - "The present paper (1) reviews the most commonly used human self-administration procedures, (2) discusses the concordance of subjective reports and self-administration within the context of medications development for substance use disorders, focusing primarily on illustrative examples from development efforts with opioid and cocaine dependence, and (3) explores the utility of applying self-administration procedures to assess the abuse liability of novel compounds, including "abuse-deterrent" formulations (ADFs)" Order ALL the reference details at left...
4.	Therapeutics 04/11/2002 - "GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND)." 07/01/1997 - "Further, these studies may provide leads to novel therapeutics for the treatment of cocaine abuse." 01/01/1986 - "This sketch of the history of psychiatry since 1886 comprises the following points: cocaine addiction; psychoanalysis; sexology; psychiatric clinics and their recent abolition in Italy; nosology; heredity and environmental factors in mental disease; therapeutics." 01/01/2005 - "The convergence of phage display and immunopharmacotherapy has allowed for an investigation of the efficacy of protein-based therapeutics acting within the CNS on the effects of cocaine in animal models and has uncovered a new tool in the battle against cocaine addiction." 05/01/2008 - "These BZT analogs possess significantly different PK and PD profiles as compared to cocaine suggesting that further evaluation as cocaine abuse therapeutics is warranted." Order ALL the reference details at left...
5.	Condoms (Condom) 03/01/2003 - "The purpose of this study was to examine readiness for using condoms among three groups (cocaine users, noncocaine drug users, and non-drug users) of African Americans living in low-income urban settings" 01/01/1998 - "This study investigated whether an active counselor intervention could increase the number of free condoms taken from dispensers placed in counselors' offices in a cocaine abuse treatment program in Philadelphia, Pennsylvania (US)" 03/01/2003 - "Cocaine users have accurate perceptions of their HIV risk, but are more likely to factor into their decisions for using condoms cost and the trouble that it takes to get condoms" 03/01/2003 - "Results of multivariate analyses indicate that, compared to the other two groups, cocaine users are at earlier stages of readiness for condom use with main partners" 03/01/2003 - "Cocaine users also reported lower levels of condom use with their main and nonmain sexual partners than both other groups" Order ALL the reference details at left...

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