|1.||Bipolar Disorder (Mania)
|2.||Schizophrenia (Dementia Praecox)
|5.||Depressive Disorder (Melancholia)
|1.||Serretti, Alessandro: 37 articles (09/2013 - 01/2002)|
|2.||Manji, Husseini K: 26 articles (09/2012 - 01/2002)|
|3.||Rybakowski, Janusz K: 25 articles (08/2015 - 05/2003)|
|4.||Zarate, Carlos A: 25 articles (03/2015 - 01/2002)|
|5.||Young, Allan H: 20 articles (01/2015 - 04/2003)|
|6.||Kasper, Siegfried: 17 articles (01/2015 - 08/2002)|
|7.||Mann, J John: 17 articles (12/2014 - 08/2004)|
|8.||Vinberg, Maj: 16 articles (01/2016 - 04/2007)|
|9.||Machado-Vieira, Rodrigo: 16 articles (03/2015 - 01/2007)|
|10.||Rietschel, Marcella: 16 articles (11/2014 - 07/2002)|
08/01/2015 - "Lithium is a widely used and highly effective treatment for mood disorders, but causes poorly characterised adverse effects in kidney and endocrine systems. "
07/01/2011 - "Lithium has been proved to be highly efficacious in the treatment of bipolar affective disorder, though a narrow therapeutic index and a high incidence of troublesome side effects often leads to poor compliance in patients. "
08/01/1999 - "Lithium remains the most widely used long-term treatment for bipolar affective disorder, but the molecular mechanisms underlying its therapeutic efficacy have not been fully elucidated. "
03/01/2004 - "Lithium has been found to be very effective in prophylactic treatment of affective disorders. "
08/23/2002 - "Various lithium (Li(+)) compounds have been proven to be effective in the therapy of bipolar affective disorder, but their mechanism of pharmacological action is not clearly defined. "
|2.||Antidepressive Agents (Antidepressants)IBA
12/10/2009 - "ECT is the most acutely effective treatment available for affective disorders and is more effective than antidepressant drugs. "
01/01/1998 - "In this case the main supporting convictions are the following: depression is a very frequent disorder and its diagnosis has improved greatly; we dispose of more or less specific agents to control depression: biological psychiatric research made great strides, particularly in the field of affective disorders; new antidepressants are properly tested before being clinically introduced. "
01/01/2013 - "Recently, new antidepressants were introduced into clinical use, with a significant reduction in side effects and equivalent efficacy on mood disorders. "
03/01/2002 - "Recently new antidepressants were introduced in the clinical use, with a significant reduction in side effects and equivalent efficacy on mood disorders. "
11/01/2010 - "More comprehensive study of TPH2 genetics is needed to increase the clinical value of the enzyme as a predictor of affective disorder risk and efficacy of antidepressant drugs."
|3.||Carbamazepine (Tegretol)FDA LinkGeneric
04/01/2000 - "In psychiatry the efficacy of the anticonvulsant carbamazepine in the prophylaxis of bipolar affective disorders is very known and so this drug has been used for a long time. "
11/01/2001 - "In this study, 74 research in-patients with affective disorders were given the DST on placebo and in a subgroup following treatment with carbamazepine. "
04/01/1988 - "Eighteen patients with rapid cycling bipolar affective disorder were recruited for an open trial of carbamazepine. "
01/01/2005 - "[Investigation on the therapeutic effect of carbamazepine on the mood disorders in Japan]."
11/01/2002 - "Based on clinical material carbamazepine seems to be active agent in treatment of affective disorders and diseases connected with organic brain lesion."
|4.||Antipsychotic Agents (Antipsychotics)IBA
12/01/2008 - "Atypical antipsychotic agents have been hypothesized to be beneficial in treating mood disorders, including TRD, as a result of their complex mechanisms of action. "
10/01/2004 - "Evidence is accumulating to support the use of atypical neuroleptics as adjunctive treatment for refractory mood disorders, although there are currently no published data on the efficacy of an atypical neuroleptic in treatment-resistant depression when a previous trial of drug from the same class has failed. "
06/01/2003 - "Efficacy of atypical antipsychotics in mood disorders."
12/01/1994 - "The efficacy of depot antipsychotic drugs in the prophylaxis of bipolar affective disorder was investigated. "
08/07/2012 - "The present study suggests that NaSSAs are superior to SSRIs or TCAs in combined therapy for mood disorders with antipsychotics in terms of EPS induction. "
|5.||Anticonvulsants (Antiepileptic Drugs)IBA
05/01/2007 - "Most antiepileptic drugs (AEDs) are considered to have effects on mood and to be effective in a number of affective disorders. "
10/01/1993 - "Anticonvulsants have been shown to be effective in many patients with psychiatric disorders, especially those with bipolar affective disorder. "
02/01/2010 - "The clinical usefulness of mood stabilizers, particularly antiepileptics, has been established as safe and effective in substance abusers with and without comorbid mood disorders. "
08/01/2005 - "Anticonvulsant drugs have shown promising results in the treatment of mood disorders, leading to the investigation of their potential efficacy in other psychiatric disorders. "
01/01/2015 - "These include mood disorders such as anxiety and depression, dose related and longer term effects of antiepileptic drugs, including on prenatal development and bone health, and neurobehavioural effects. "
|6.||Serotonin (5 Hydroxytryptamine)IBA
01/01/1994 - "No deranged presynaptic monoamine metabolism in the brain has been directly demonstrated in mood disorders, in spite of the rich but indirect pharmacological evidence for a decreased efficacy of monoaminergic synaptic transmission in depression, especially as for serotonin. "
05/15/2015 - "These findings have important implications for understanding the relationship between the circadian and serotonin systems in both the healthy brain and in affective disorders, as well as for the design of future molecular imaging studies. "
03/01/2015 - "This study suggests that serotonin signaling through postsynaptic 5-HT1A receptors in the hippocampus is critical for the antidepressant-like effects of a cholinergic drug and begins to elucidate the molecular mechanisms underlying interactions between the serotonergic and cholinergic systems related to mood disorders. "
01/01/2015 - "The findings of our study suggest that monotonous environment independently contributes to impairment in mood state and disrupting monotony by intervention of novel objects during social isolation prevents mood disorders and emotional maladaptation through up regulation of hippocampal pIGF-1R and increase in serotonin."
01/01/2012 - "Dorsal raphe nucleus (DR) is a major source of serotonin in the brain, and previous studies have reported within it alterations in 5-HT-related gene expression, protein levels, receptor binding, and morphological organization in mood disorders. "
|7.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
03/01/1999 - "Valproic acid (VPA) is a potent broad-spectrum anti-epileptic with demonstrated efficacy in the treatment of bipolar affective disorder. "
01/22/1999 - "Valproic acid (VPA) is a potent broad spectrum anticonvulsant with demonstrated efficacy in the treatment of Bipolar Affective Disorder, but the biochemical basis for VPA's antimanic or mood-stabilizing actions have not been fully elucidated. "
09/01/2006 - "The results of such a study would give us a clearer understanding of what the desirable therapeutic range is for valproate in bipolar affective disorder and what, if any, monitoring should be undertaken."
01/01/2003 - "Eighteen patients with DSM-IV diagnosis of either bipolar affective disorder or schizomania who met the study criteria were recruited (9 in the intravenous and 9 in the oral valproate group). "
07/01/1998 - "A series of open studies indicates a reduction in frequency and intensity of manic and depressive episodes with the long-term administration of valproate suggesting efficaciousness in the prophylaxis of bipolar affective disorders. "
|8.||lamotrigine (Lamictal)FDA LinkGeneric
02/01/2007 - "This study provides preliminary data that lamotrigine may be effective in adolescents with mood disorders. "
04/01/2013 - "Lamotrigine (LTG), a phenyltriazine derivative and anti-epileptic drug, has emerged as an effective first-line treatment for bipolar mood disorder. "
05/01/2014 - "This study was conducted to investigate the hypothesis that lamotrigine may have a therapeutic window for mood disorders. "
01/01/2013 - "Prospective, open-label trial measuring satisfaction and convenience of two formulations of lamotrigine in subjects with mood disorders."
02/01/2007 - "The aims of this study are to evaluate the preliminary effectiveness and safety of lamotrigine in adolescent mood disorders. "
|9.||Lithium Carbonate (Eskalith)FDA LinkGeneric
04/01/2010 - "We investigated whether polymorphisms in the Rev-erb- alpha gene are associated with the long-term efficacy of lithium carbonate therapy in bipolar affective disorder. "
04/01/1985 - "Over half of lithium carbonate-treated affective disorder patients in remission also showed impairment of smooth-pursuit eye movements. "
02/20/2013 - "The study was performed on 71 patients with bipolar mood disorder (21 males, 50 females), aged 31-82 (59±12) years, which have been treated with lithium carbonate for at least 5 years (5-37 years, mean 15 years). "
09/05/2007 - "The study was performed on 111 patients with bipolar mood disorders (43 male, 68 female), aged 30-77 (mean 54 years) who have been treated with lithium carbonate for at least 5 years (5-27 years, mean 15 years). "
01/01/2005 - "In this study, the 5-HTTLPR was estimated in 67 patients with bipolar mood disorder, receiving lithium carbonate for prophylactic purposes for the period of more than 5 years (mean 15 years). "
|10.||Risperidone (Risperdal Consta)FDA LinkGeneric
08/01/2006 - "Clinical data on risperidone have demonstrated efficacy and satisfactory tolerability in improving angry, aggressive, self-injurious, and disruptive symptoms and behavior in children with pervasive developmental disorders and mood disorders. "
06/01/2005 - "This case report suggests that risperidone may be effective in some neurological motor disorders comorbid with mood disorders."
07/01/2004 - "This is a case report where risperidone mono therapy has been found to be effective in prophylaxis of bipolar affective disorder. "
09/01/2004 - "In an open, multi-center, 6-month study, risperidone seems to be effective and safe as long-term adjunctive therapy in treatment-resistant bipolar and schizo-affective disorders, with no exacerbation of manic symptoms. "
08/01/2001 - "Group for the Study of Risperidone in Affective Disorders (GSRAD)."
|1.||Phototherapy (Light Therapy)
01/01/2014 - "In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm disruption. "
11/09/2010 - "Light therapy can be an effective treatment for mood disorders, suggesting that light is able to affect mood state in the long term. "
10/15/1992 - "The pathophysiology of SAD, its relationship to nonseasonal affective disorders, and the mechanism of action of light therapy, which is effective in treating SAD, remain to be elucidated (Depue et al 1989; Jacobsen et al 1987; James et al 1986; Joseph-Vanderpool et al 1991; Skwerer et al 1988, Terman et al 1989). "
04/01/2005 - "The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders. "
12/01/2013 - "This pilot study aims to examine whether the efficacy of Bright Light Therapy (BLT) is similar for different subtypes of mood disorders. "
|2.||Drug Therapy (Chemotherapy)
01/01/2004 - "Pharmacogenetics holds some promise for improving the treatment of mood disorders by utilising information about genetic polymorphisms to match patients to the drug therapy that is the most effective with the fewest side effects. "
09/01/2008 - "The objective of the present study is to compare the efficacy of psychotherapy versus drug therapy in the treatment of affective disorders. "
01/01/1998 - "The National Institute of Mental Health (NIMH) Collaborative Study of Long-Term Maintenance Drug Therapy in Recurrent Affective Illness was a multicenter randomized controlled clinical trial designed to determine the efficacy of a pharmacotherapy for the prevention of the recurrence of unipolar affective disorders. "
01/01/2005 - "Genes encoding target receptors and signal transduction systems may predict the efficacy of drug therapy in mood disorders. "
08/01/2015 - "We surveyed via Internet the national membership of the American Society of Clinical Psychopharmacology (ASCP) to study preferred pharmacotherapy strategies and factors that influence medication choices for patients with mood disorders. "
01/01/1999 - "The identification of the functions of these genes offers the potential not only for improved therapeutics for reducing the morbidity and mortality associated with mood disorders, but may also provide important clues about the underlying pathophysiology."
12/01/2000 - "Together, these studies suggest that mood disorders may be associated with impaired neuroplasticity and cellular resiliency, findings that may have major implications for our understanding of mood disorders, and for the development of improved therapeutics."
05/01/2008 - "Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders."
04/15/2003 - "The development of novel, nonaminergic-based therapeutics holds much promise for improved treatment of severe, refractory mood disorders."
01/01/2002 - "This research progress holds much promise for the development of novel therapeutics for the treatment of severe, refractory mood disorders."
07/01/2013 - "Whereas the functional impairment and the level of improvement in mood disorder corresponded to previous efficacy studies, the ADHD patients were more impaired and improved less after treatment. "
10/01/2007 - "After treatment, the mood disorder improved and FPG, PG 2 h, GHb levels decreased in the two groups, with the observation group being better than the control group (P < 0.05). "
01/01/2013 - "Children with nonanxiety comorbidity and especially with comorbid mood disorders exhibit greater severity at the outset and remain worse after treatment. "
12/01/2010 - "It should be noted that in one quarter of cases, women seek early withdrawal of the contraceptive implant (23% in postabortion and 21% in the other group), a rate that is 39% in patients under 25years and 47% in patients who reported a mood disorder. "
06/01/2006 - "The findings confirm the seriousness and adverse psychosocial consequences of psychotic, unipolar and bipolar mood disorders in this age group, highlighting the need for consistent and systematic follow up of young people after treatment."
|5.||Vagus Nerve Stimulation
01/01/2015 - "Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study."
04/01/2012 - "Existing neuroimaging studies of vagus nerve stimulation (VNS) in treatment resistant major depression (TRMD) suggest that many brain regions (eg, prefrontal cortex, thalamus, cingulate cortex, insular cortex) associated with mood disorders undergo alterations in blood flow/metabolism. "
09/05/2013 - "We used a range of contemporary tools to rate the treatment histories of patients in a variety of care settings which included: primary care; affective disorders specialist clinics; patients receiving ECT; referrals to a tertiary affective disorders service; and patients undergoing neurosurgical treatment (vagus nerve stimulation or anterior cingulotomy) for chronic, refractory major depression. "
07/01/2003 - "Brain stimulation methods in the treatment of affective disorder are electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), and deep brain stimulation (DBS). "
01/01/1999 - "Vagal nerve stimulation, a treatment already known to be effective in the epilepsies, is presently under investigation for effectiveness in affective disorder. "