Cyclin A

A cyclin subtype that has specificity for CDC2 PROTEIN KINASE and CYCLIN-DEPENDENT KINASE 2. It plays a role in progression of the CELL CYCLE through G1/S and G2/M phase transitions.

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Networked: 789 relevant articles (12 outcomes, 96 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nesland, J M: 8 articles (03/2009 - 09/2000)
2.	Fitzgerald, Rebecca C: 5 articles (06/2020 - 11/2004)
3.	Watanabe, Jun: 5 articles (02/2020 - 07/2004)
4.	Huang, Hsuan-Ying: 5 articles (10/2013 - 01/2006)
5.	Li, Chien-Feng: 5 articles (10/2013 - 01/2006)
6.	Ahlin, Cecilia: 5 articles (01/2013 - 09/2009)
7.	Fjällskog, Marie-Louise: 5 articles (01/2013 - 09/2009)
8.	Holm, Ruth: 5 articles (02/2012 - 01/2004)
9.	Coleman, Nicholas: 5 articles (03/2010 - 10/2003)
10.	van Diest, Paul J: 5 articles (08/2007 - 11/2002)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2020 - "Tumors with high MCM2, Cyclin A or PHH3 expression showed significantly higher rate of pathological complete remission. " 08/25/2009 - "In contrast, patients who had positive results for ER-alpha and PR-B, and negative results for cyclin A and p53 had favorable characteristics, such well differentiated tumor, early clinical stage, negative LVSI, and less MI, and had a good prognosis. " 11/15/2003 - "High cyclin A expression (>19% positive cancer cell nuclei, the highest tertile) was associated with a high rate of locoregional tumor recurrence and unfavorable disease-free and overall survival as compared with cases with a lower expression (p = 0.025, 0.032, and 0.042, respectively). " 11/01/2000 - "Positive cyclin A showed a significantly greater increase in T4 tumors than in those of other stages, and negative p27 showed a significantly greater decrease in T4 tumors than in large T3 stage tumors (tumor size > or = 4.0 cm). " 12/01/2007 - "alphaE2 is an effective agent for inhibition of DHT-induced PSA, cyclin A, cyclin D1 gene expression, and cell proliferation in LAPC-4 cells, and tumor growth in LAPC-4 xenograft mice."
2.	Glioma (Gliomas) 06/01/2016 - "The present study reveals that SeC time- and dose-dependently inhibited U251 and U87 human glioma cells growth by induction of S-phase cell cycle arrest, followed by the marked decrease of cyclin A. " 09/01/2015 - "Tissue samples of 186 diagnosed glioma patients were examined immunohistochemically for Cyclin A and Ki-67 expression. " 09/01/2015 - "The present study aimed to analyze the expression and mutation of Cyclin A and Ki-67 in gliomas, and determine their correlation with tumor progression. " 09/01/2015 - "In conclusion, Cyclin A and Ki-67 are highly expressed in glioma tissues, and their expression and mutation are associated with the lymphatic metastasis of glioma in the brain. " 09/01/2015 - "Statistically significant differences were observed in the mutation rate of Ki-67 (P<0.05), but not Cyclin A (P>0.05), between the gliomas and metastatic tumors. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "Cyclin A overexpression in all components was 66.7% in WTs with metastasis and 31.3% in WTs without metastasis (p = 0.265, Fisher test). " 08/01/2014 - "Both cyclin A and WHO 2010 grade were very specific in identifying patients at risk for metastasis (100% versus 96%). " 12/21/2012 - "The results of cytoplasmic HuR and nuclear cyclin A expressions were correlated with disease-specific survival (DSS), metastasis-free survival (MeFS), urinary bladder recurrence-free survival (UBRFS), and various clinicopathological factors. " 08/05/2008 - "The frequency of Ki67-positive cells was found to be highly correlated with the frequency of cyclin A-positive cells, and both proliferation markers were equally good to predict risk of distant metastases. " 10/01/2007 - "For each cut-off value the relative risk (RR) for metastasis-free survival (MFS) and overall survival (OS) was calculated comparing patients with high versus low cyclin A or Ki67 expression. "
4.	Esophageal Squamous Cell Carcinoma 10/01/1996 - "Determination of the prognostic significance of unscheduled cyclin A overexpression in patients with esophageal squamous cell carcinoma." 03/01/2003 - "Ki-67 and cyclin A staining index (SI), and p27 labeling index were examined and detailed pathologic examinations were conducted on tumors from 60 patients (48 males and 12 females with surgically resected esophageal squamous cell carcinoma). " 11/01/2000 - "T4 esophageal squamous cell carcinoma has a poor prognosis, which is associated with increased p27-negative and cyclin A-positive growth signals in the tumor and with low TIL density in the host." 10/01/1996 - "The expression of cyclin A protein was retrospectively investigated in 124 patients with human esophageal squamous cell carcinoma with immunohistochemical techniques using antibody to cyclin A protein (BF683). " 10/01/2012 - "The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). "
5.	Colonic Neoplasms (Colon Cancer) 04/01/2021 - "The GBC significantly inhibited colon cancer cell growth, and its anti-proliferative effect involved mechanisms including G2/M cell cycle arrest via upregulation of cyclin A and induction of apoptosis via regulation of apoptotic related gene expressions. " 08/01/2010 - "In HCT116 colon cancer cells, the expression of cyclin A was not changed or decreased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin A was increased at a DCA concentration of 20 µM. " 11/01/2002 - "In the present study, we sought to determine whether cyclin A kinase activity is involved in mediating the interaction between E2F-1 and chemotherapeutic agents in colon cancer cells. " 06/01/2012 - "We demonstrate that nimbolide effectively inhibited proliferation of WiDr colon cancer cells through inhibition of cyclin A leading to S phase arrest. " 11/01/2002 - "Inhibition of cyclin A kinase activity in E2F-1 chemogene therapy of colon cancer."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	DNA (Deoxyribonucleic Acid)
3.	Paclitaxel (Taxol)
4.	Cyclin C
5.	Phenol (Carbolic Acid)
6.	Connective Tissue Growth Factor
7.	Kalinin
8.	Cyclin E
9.	Cyclin D1
10.	Cyclin B1

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Radiotherapy
4.	Neoadjuvant Therapy
5.	Chemoprevention