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Taq Polymerase

A heat stable DNA-DIRECTED DNA POLYMERASE from the bacteria Thermus aquaticus. It is widely used for the amplification of genes through the process of POLYMERASE CHAIN REACTION. EC 2.7.7.-.
Also Known As:
Taq1 Polymerase; Thermus aquaticus Polymerase; DNA Polymerase, Taq; Polymerase, Taq; Polymerase, Taq DNA; Polymerase, Taq1; Polymerase, Thermus aquaticus; aquaticus Polymerase, Thermus; Taq DNA Polymerase
Networked: 37 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Akkoç, Senem: 1 article (03/2020)
2. Coban, Burak: 1 article (03/2020)
3. Cömert, Füsun: 1 article (03/2020)
4. Kandemir, Irfan: 1 article (03/2020)
5. Yildiz, Ufuk: 1 article (03/2020)
6. Campbell, Colin: 1 article (01/2018)
7. Chesner, Lisa N: 1 article (01/2018)
8. Alcaro, Stefano: 1 article (03/2017)
9. Betari, Nibal: 1 article (03/2017)
10. Calcabrini, Cinzia: 1 article (03/2017)

Related Diseases

1. Ulcer
2. Acquired Immunodeficiency Syndrome (AIDS)
3. Neoplasms (Cancer)
11/01/2022 - "To increase mismatch discrimination, mutations were generated in the Thermus aquaticus (Taq) DNA polymerase, the most efficient variant was selected, and its performance evaluated in single nucleotide polymorphism and cancer mutation genotyping. "
03/01/2020 - "The results show that both compounds (1 and 2) and the parent compound NI have strong cytotoxic activities against Beas-2B, MCF-7, HepG2 and MDA-MB-231 cancer cell lines, antimicrobial activities against Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and inhibitory activities towards Taq-polymerase and transcriptase. "
05/15/1991 - "We used a standard restriction fragment length polymorphism assay of PCR-amplified c-Ki-ras to detect codon 12 mutations in tumor cells and found a cumulative error frequency for Taq DNA polymerase of one codon 12 mutation per 2 X 10(4) molecules of total amplification product. "
03/10/2017 - "Among these, compound 9 emerges as the most interesting of the series being able to bind telomeric G-quadruplex (ΔTm = 29 °C at 2.5 μM), to inhibit the activity of DNA processing enzymes, such as topoisomerase II and TAQ-polymerase, and to exert antiproliferative effects in the NCI panel of cancer cell lines with GI50 values in the micro-to nanomolar concentration range (i.e. "
07/01/2010 - "Genomic DNA from cancer cells is pretreated with a methylation-sensitive restriction endonuclease, followed by PCR amplification in the presence of fluorescein-labeled dNTP and Taq polymerase. "
4. Coinfection
5. Marginal Zone B-Cell Lymphoma (MALT Lymphoma)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. DNA Primers
3. DNA Adducts
4. Complementary DNA (cDNA)
5. DNA-Directed RNA Polymerases (RNA Polymerase)
6. RNA (Ribonucleic Acid)
7. RNA-Directed DNA Polymerase (Reverse Transcriptase)
8. Proteins (Proteins, Gene)
9. Enzymes
10. DNA Restriction Enzymes (Restriction Endonuclease)