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Nuclear Localization Signals (Nuclear Localization Signal)

Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.
Also Known As:
Nuclear Localization Signal; NLS Peptide; Nuclear Localization Signal Peptide; NLS Peptides; Peptide, NLS; Peptides, NLS; Signal, Nuclear Localization; Signals, Nuclear Localization
Networked: 281 relevant articles (1 outcomes, 16 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Jans, David A: 5 articles (01/2022 - 09/2002)
2. Wagstaff, Kylie M: 3 articles (01/2022 - 03/2012)
3. Benito, Antoni: 3 articles (08/2021 - 10/2012)
4. Castro, Jessica: 3 articles (08/2021 - 10/2012)
5. Ribó, Marc: 3 articles (08/2021 - 10/2012)
6. Vilanova, Maria: 3 articles (08/2021 - 10/2012)
7. Zhong, Liang: 3 articles (12/2019 - 01/2016)
8. El-Sayed, Mostafa A: 3 articles (03/2014 - 09/2007)
9. Reilly, Raymond M: 3 articles (11/2013 - 08/2012)
10. Hasegawa, Sumitaka: 2 articles (07/2022 - 10/2015)

Related Diseases

1. Testicular Neoplasms (Testicular Cancer)
2. Infections
3. Breast Neoplasms (Breast Cancer)
4. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
5. Glioma (Gliomas)
10/01/2014 - "Here, we overexpressed a wild type or a dominant negative form of E47 (dnE47) that lacks its nuclear localization signal thus preventing nuclear translocation of bHLH proteins in long-term glioma cell lines and in glioma-initiating cell lines and analyzed the effects in vitro and in vivo. "
11/17/1997 - "Glypican and biglycan in the nuclei of neurons and glioma cells: presence of functional nuclear localization signals and dynamic changes in glypican during the cell cycle."
09/01/2021 - "In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering a therapeutic, carcinoma cell-selective apoptosis gene, apoptin into human primary glioma (GBL-14) cells and human dermal fibroblasts. "
08/01/2012 - "Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons."
11/17/1997 - "Nuclear localization of glypican beta-galactosidase or Fc fusion proteins in transfected 293 cells and C6 glioma cells was greatly reduced or abolished after mutation of the basic amino acids or deletion of the sequence containing the nuclear localization signal, and no nuclear staining was seen in the case of heparan sulfate and chondroitin sulfate proteoglycans that do not possess a nuclear localization signal, such as syndecan-3 or decorin (which is closely related in structure to biglycan). "

Related Drugs and Biologics

1. Antigens
2. Proteins (Proteins, Gene)
3. Serine (L-Serine)
4. Peptides (Polypeptides)
5. Nuclear Export Signals (Nuclear Export Signal)
6. DNA (Deoxyribonucleic Acid)
7. Basic Amino Acids (Basic Amino Acid)
8. Enzymes
9. Alanine (L-Alanine)
10. Capsid Proteins (Capsid Protein)

Related Therapies and Procedures

1. Microbubbles
2. Therapeutics
3. Nanospheres
4. Radioimmunotherapy
5. Lasers (Laser)