|1.||Kim, Youn Wha: 8 articles (10/2012 - 10/2010)|
|2.||Zlobec, Inti: 6 articles (01/2013 - 05/2007)|
|3.||Lugli, Alessandro: 6 articles (01/2013 - 05/2007)|
|4.||Park, Yong-Koo: 5 articles (10/2012 - 11/2010)|
|5.||Kim, Hyun-Soo: 5 articles (07/2012 - 12/2010)|
|6.||Baritaki, Stavroula: 5 articles (06/2012 - 10/2007)|
|7.||Kim, Gou Young: 5 articles (05/2012 - 11/2010)|
|8.||Bonavida, Benjamin: 5 articles (01/2011 - 10/2007)|
|9.||Yeung, Kam C: 3 articles (01/2013 - 10/2007)|
|10.||Al-Mulla, Fahd: 3 articles (01/2013 - 10/2005)|
01/01/2014 - "Raf-1 kinase inhibitor protein (RKIP) plays a critical role in tumor development by regulating cell functions such as invasion, apoptosis and differentiation. "
01/01/2013 - "Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers and is known to inhibit Ras/Raf/MEK/ERK signaling. "
10/01/2012 - "Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor and useful prognostic marker for a variety of human cancers. "
12/01/2010 - "Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers. "
10/01/2010 - "However, Raf-1 kinase inhibitor protein expression was not associated with tumor size, multifocality, extrathyroidal invasion, or status of the tumor border. "
|2.||Breast Neoplasms (Breast Cancer)
01/01/2013 - "Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer."
12/01/1998 - "The results show that E2 can induce raf-1 kinase activity in MCF-7 breast cancer cells associated with the expression of an early growth response gene and modulation of ER signalling."
01/01/1995 - "Baseline expression of the 74-kDa or activated form of the Raf-1 kinase appeared to be elevated in the breast cancer cells studied, indicating constitutive activation. "
01/01/1995 - "The role of Raf-1 kinase in breast cancer has not been studied. "
10/15/2005 - "Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis."
|3.||Ovarian Neoplasms (Ovarian Cancer)
07/01/2000 - "However, in the ovarian cancer cell lines (CA-OV3, SK-OV3, 2780/CP and OAW42/CP) that have a mutant TP53 (TP53mut), the cytotoxicity induced by 60 nM paclitaxel exhibited the same relationship to Raf-1 kinase activity as previously observed in cervical tumor cell lines. "
07/01/2000 - "The relationship between Raf-1 kinase activity and the sensitivity to clinically relevant paclitaxel concentrations was determined in four ovarian cancer cell lines (CA-OV3, SK-OV3, 2780/WT and OAW42/WT). "
07/01/2000 - "In light of the possibility that Raf-1 kinase inhibitors could be used to enhance paclitaxel responsiveness in ovarian cancer, we have characterized the Raf-1 kinase dependency of paclitaxel resistance in ovarian cancer cells. "
07/01/2000 - "Raf-1 kinase activity predicts for paclitaxel resistance in TP53mut, but not TP53wt human ovarian cancer cells."
07/01/2000 - "These data suggest that the therapeutic efficacy of paclitaxel in ovarian cancer patient whose tumors have TP53mut might be increased if it is administered in combination with Raf-1 kinase inhibitors, e.g., ISIS 5132."
|4.||Colorectal Neoplasms (Colorectal Cancer)
05/28/2013 - "This study evaluates the geographic expression pattern of Raf-1 Kinase Inhibitor Protein (RKIP) in colorectal cancer (CRC) in correlation with clinicopathological and molecular features, markers of epithelial-mesenchymal transition (EMT) and survival outcome. "
07/01/2012 - "Reduced expression of Raf-1 kinase inhibitor protein (RKIP) has been documented in a number of human malignancies, including colorectal carcinoma (CRC). "
01/01/2008 - "Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression."
05/01/2007 - "Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer."
12/01/2011 - "Our findings show that, in colorectal cancer progression, vascular endothelial growth factor overexpression seems to play a role in the tumor center, whereas Laminin5γ2-positivity combined with Raf-1 kinase inhibitor protein loss is associated with tumor invasion at the front."
11/01/2010 - "Because of the lack of reliable prognostic markers, the aim of this study was to investigate the prognostic significance of Raf-1 kinase inhibitory protein expression in gallbladder carcinomas. "
01/01/2012 - "Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater."
12/01/2010 - "Raf-1 kinase inhibitory protein expression in thyroid carcinomas."
11/01/2010 - "Kaplan-Meier curves showed that patients with Raf-1 kinase inhibitory protein-negative or weakly positive gallbladder carcinoma had a significantly shorter overall survival than did patients with Raf-1 kinase inhibitory protein-positive gallbladder carcinoma (median, 14 versus 120 months; P = .011). "
11/01/2010 - "The differences in Raf-1 kinase inhibitory protein expression in gallbladder carcinoma versus nongallbladder carcinoma tissues (P < .001), and in nodal metastatic gallbladder carcinoma versus primary gallbladder carcinoma (P = .009), were statistically significant. "
|5.||Protein Kinases (Protein Kinase)
|6.||Epidermal Growth Factor Receptor (EGF Receptor)
|7.||Ephrin-B2 (Ephrin B2)
|8.||Mitogen-Activated Protein Kinase Kinases (MEKs)
|9.||NF-kappa B (NF-kB)
|1.||Neck Dissection (Radical Neck Dissection)