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(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide

A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)
Also Known As:
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Mesylate, (trans)-(+)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Mesylate, (trans)-(+-)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Monohydrochloride, (trans)-(+-)-Isomer,; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Monomethanesulfonate, (trans)-(+)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Monomethanesulfonate, (trans)-(+-)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Monomethanesulfonate, (trans)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (1R-cis)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (1S-cis)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (trans)-(+-)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (trans)-(-)-Isomer; U-50,488H; U-50488; U-50488H; U50488H; trans-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide; trans-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide Hydrochloride; U 50,488H; U 50488; U 50488H; U50,488H; U50488; Benzeneacetamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, (trans)-Isomer
Networked: 186 relevant articles (9 outcomes, 22 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Li, Juan: 11 articles (08/2014 - 09/2007)
2. Fan, Rong: 9 articles (08/2014 - 09/2007)
3. Pei, Jian-Ming: 8 articles (09/2013 - 04/2006)
4. Wang, Yue-Min: 8 articles (09/2013 - 04/2006)
5. Kaye, Alan David: 7 articles (09/2013 - 04/2009)
6. Guo, Hai-Tao: 7 articles (09/2013 - 04/2006)
7. Xia, Qiang: 7 articles (08/2010 - 06/2003)
8. Yi, Ding-Hua: 6 articles (09/2013 - 09/2007)
9. Yu, Shi-Qiang: 6 articles (09/2013 - 09/2007)
10. Zhang, Shu-Miao: 5 articles (09/2013 - 05/2009)

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2. Pain (Aches)
3. Ischemia
4. Anoxia (Hypoxia)
5. Spinal Cord Injuries (Spinal Cord Injury)

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1. kappa Opioid Receptors (kappa Opioid Receptor)
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6. Thyrotropin-Releasing Hormone (Protirelin)
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8. nalmefene (Revex)
9. rimcazole
10. Opioid Receptors (Opioid Receptor)

Related Therapies and Procedures

1. Analgesia
2. Injections
3. Ligation
4. Intradermal Injections
5. Anesthesia