HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Ribosomal Protein S6 Kinases (S6 Kinase)

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.
Also Known As:
S6 Kinase; Ribosomal Protein S6 Kinase; S6-H4 Kinase; S6 H4 Kinase
Networked: 524 relevant articles (11 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Liu, Yang: 12 articles (01/2021 - 05/2016)
2. Feng, Lin: 11 articles (10/2019 - 05/2016)
3. Jiang, Wei-Dan: 11 articles (10/2019 - 05/2016)
4. Wu, Pei: 11 articles (10/2019 - 05/2016)
5. Zhou, Xiao-Qiu: 11 articles (10/2019 - 05/2016)
6. Kuang, Sheng-Yao: 10 articles (10/2019 - 05/2016)
7. Tang, Ling: 10 articles (10/2019 - 05/2016)
8. Tang, Wu-Neng: 9 articles (10/2019 - 05/2016)
9. Jiang, Jun: 9 articles (01/2019 - 05/2016)
10. Zhang, Yong-An: 9 articles (03/2018 - 05/2016)

Related Diseases

1. Insulin Resistance
2. Infarction (Infarctions)
3. Fibrosis (Cirrhosis)
4. Parkinson Disease (Parkinson's Disease)
04/03/2015 - "This study was aim to determine the role and underling mechanism of ribosomal protein S6 kinases 1 (S6k1) phosphorylation in Parkinson's disease (PD). "
01/01/2018 - "Compared with the Parkinson's disease group, the moxibustion group showed significantly greater tyrosine hydroxylase immunoreactivity and expression of light chain 3-II protein in the substantia nigra, and their behavioral score, α-synuclein immunoreactivity, the expression of phosphorylated mTOR and phosphorylated ribosomal protein S6 kinase (p-p70S6K) in the substantia nigra were significantly lower. "
01/01/2019 - "elegans) 3; RFP: red fluorescent protein; RPS6KB1: ribosomal protein S6 kinase, polypeptide 1; SDS-PAGE: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SQSTM1: sequestosome 1; tfLC3: mRFP-eGFP-LC3; TRGL6: Thy1 mRFP eGFP LC3-line 6; PCR: polymerase chain reaction; PD: Parkinson disease."
01/01/2018 - "6-OHDA: 6-hydroxydopamine; AMPK: AMP-activated protein kinase; ATG: autophagy related; CAV1: caveolin 1; ER: endoplasmic reticulum; FN1: fibronectin 1; GSH: glutathione; IDE: insulin degrading enzyme; IL: interleukin; LDH: lactate dehydrogenase; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MEF: mouse embryonic fibroblast; MTOR: mechanistic target of rapamycin kinase; NAC: N-acetyl-L-cysteine; PARK7/DJ-1: Parkinsonism associated deglycase; PD: Parkinson disease; RPS6KB1/p70S6K: ribosomal protein S6 kinase B1; RPN1: ribophorin I; ROS: reactive oxygen species; ULK1: unc-51 like autophagy activating kinase 1; WT: wild-type."
5. AIDS-Related Complex (ARC)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Proto-Oncogene Proteins c-akt (Protein Kinase B)
3. Messenger RNA (mRNA)
4. Cytokines
5. 70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
6. TOR Serine-Threonine Kinases
7. Sirolimus (Rapamycin)
8. Insulin (Novolin)
9. Phosphotransferases (Kinase)
10. Peptide Initiation Factors (Initiation Factor)

Related Therapies and Procedures

1. Moxibustion
2. Therapeutics
3. Nephrectomy
4. Ligation
5. Neoadjuvant Therapy