|1.||Swisher, Stephen G: 10 articles (05/2015 - 04/2002)|
|2.||Roth, Jack A: 8 articles (05/2015 - 04/2002)|
|3.||Pataer, Abujiang: 7 articles (11/2010 - 04/2002)|
|4.||Hunt, Kelly K: 6 articles (08/2008 - 04/2002)|
|5.||Silverman, Robert H: 5 articles (09/2013 - 02/2005)|
|6.||Williams, Bryan R G: 5 articles (10/2012 - 02/2005)|
|7.||Barber, Glen N: 5 articles (01/2010 - 04/2002)|
|8.||Vorburger, Stephan A: 5 articles (11/2005 - 04/2002)|
|9.||May, W Stratford: 4 articles (09/2015 - 10/2003)|
|10.||Samuel, Charles E: 4 articles (06/2012 - 10/2002)|
11/01/2012 - "dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection."
04/01/2012 - "HeLa cells made stably deficient in ADAR1 (ADAR1(kd)) were compared to vector control (CON(kd)) and protein kinase PKR-deficient (PKR(kd)) cells for IFN-β induction following infection with either parental (wild-type [WT]) recombinant Moraten vaccine strain measles virus (MV) or isogenic knockout mutants deficient for either V (V(ko)) or C (C(ko)) protein expression. "
01/01/2011 - "Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). "
01/20/2010 - "The level of phosphorylated protein kinase PKR was increased in ADAR1-deficient cells compared to ADAR1-sufficient cells following IFN treatment, regardless of viral infection. "
05/12/2009 - "Type I IFN-induced expression of dsRNA-activated protein kinase (PKR) during viral infection is a well-established antiviral mechanism. "
09/29/2015 - "Several studies have reported that pre-miR-886 plays a tumor-suppressive role in a wide range of cancer cells through its activity as a cellular protein kinase RNA-activated (PKR) ligand and repressor. "
08/01/2014 - "The double-strand RNA-dependent protein kinase, PKR, plays a central role in inflammatory/chronic stress-mediated pathologies such as cancer, diabetes, and neuro/muscular degenerative diseases. "
02/01/2009 - "Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity."
01/01/2009 - "Although some consequences of eIF2alpha phosphorylation are cytoprotective, phosphorylation of eIF2alpha by RNA-dependent protein kinase (PKR) is largely proapoptotic and tumor suppressing. "
08/01/1999 - "NS5A from IFN-resistant strains of HCV can repress the PKR protein kinase, a mediator of the IFN-induced antiviral and apoptotic responses of the host cell and a tumor suppressor. "
|3.||Melanoma (Melanoma, Malignant)
10/01/2011 - "In the course of DENV life cycle, we observed the activation of host genes involved in the antiviral immune responses such as intracellular RNA virus sensors Toll-Like Receptor-3, Retinoic Acid Inducible Gene-I, Melanoma Differentiation Associated gene-5 and the RNA-dependent protein kinase R. "
05/01/2005 - "Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR."
01/01/2007 - "Our previous studies demonstrated that adenovirus-mediated overexpression of melanoma differentiation-associated gene-7 (Ad-mda7) leads to rapid induction of double-stranded RNA-dependent protein kinase (PKR) and activation of its downstream targets, resulting in apoptosis induction in human lung cancer cells. "
12/12/2002 - "Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR."
04/15/2002 - "Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR)."
|4.||Hepatocellular Carcinoma (Hepatoma)
04/01/2009 - "The present study shows that double-stranded RNA-dependent protein kinase (PKR) regulates the protein expression level and phosphorylation of Bcl-2 and plays an anti-apoptotic role in human hepatocellular carcinoma cells (HepG2). "
08/01/2011 - "We found that while HBV replication in transfected human hepatoma Huh-7 cell was severely inhibited by IFN-α treatment as reported previously, this inhibition was markedly impaired in the cell in which the expression of IFN-inducible, double-stranded RNA-dependent protein kinase (PKR) was stably and specifically suppressed through RNA-interference. "
09/13/2001 - "Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein."
06/01/2009 - "We show here that HCV JFH1 infection of human hepatoma Huh-7 cells leads to the activation of IFN-inducible protein kinase PKR and phosphorylation of the translation initiation factor eIF2alpha. "
11/01/2008 - "We also investigated the role of IFN-stimulated gene factor3 (ISGF3) complex in IFN-alpha-mediated anti-HBV responses in human hepatoma cells by measuring the mRNA of the three genes within ISGF3 (STAT1, STAT2 and IRF-9) using semiquantitative reverse-transcription PCR (RT-PCR), and expression of the three proteins by western blot, and the mRNA and protein of dsRNA-dependent protein kinase (PKR). "
10/01/2010 - "TNF stimulation resulted in the translocation of the cytosolic p65 kinase IKKε to the nucleus and also to promyelocytic leukemia (PML) nuclear bodies. "
10/01/2007 - "[Effect of targeted activation of protein kinase PKR on proliferation of leukemia cell line K562 and its mechanism]."
04/10/2004 - "There are a number of observations that suggest the dsRNA-activated protein kinase, PKR, may play an active role in formation and maintenance of leukemia, including nonrandom chromosomal deletions in acute leukemia as well as truncations and deletions of the PKR gene in some leukemia cell lines. "
04/04/1996 - "Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q- associated leukemias."
03/25/1977 - "There appears to be a functional similarity between this inhibitor from Friend leukemia cells and the hemin-controlled repressor from reticulocytes."
|2.||pppA(2'p5'A)n-dependent ribonuclease (RNase L)
|5.||Double-Stranded RNA (RNA, Double Stranded)
|6.||Messenger RNA (mRNA)
|7.||Eukaryotic Initiation Factor-2 (EIF 2)
|8.||Proteins (Proteins, Gene)
|9.||Prokaryotic Initiation Factor-2
|10.||Tretinoin (Retinoic Acid)