Alkyl and Aryl Transferases

12/01/2021 - "However, the drug resistance mediated by O6-alkylguanine-DNA alkyltransferase (AGT) and absence of tumor-targeting ability largely decrease the antitumor efficacy of CENUs. "
07/01/1989 - "Further studies are indicated to assess the extent to which biochemical modulation of alkyltransferase reduces tumor nitrosourea resistance in vivo."
07/01/2000 - "O6-alkylguanine-DNA alkyltransferase (O6-AGT), capable of repairing DNA damage, is responsible for tumor cell resistance to nitrosourea. "
04/01/2000 - "Some tumor cells do not express alkyltransferase despite having an intact gene. "
05/15/1999 - "O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair."

10/01/2002 - "Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells."
07/01/1994 - "Disposition and metabolism of O6-alkylguanine-DNA alkyltransferase inhibitor in nude mice bearing human melanoma."
07/01/1992 - "O6-alkylguanine-DNA alkyltransferase activity in human malignant melanoma."
09/15/1990 - "Drug-induced cytotoxic effects, uptake kinetics, DNA damage, and O6-alkylguanine-DNA alkyltransferase activity were determined in 3 melanoma cell lines: the murine B16 and 2 human metastatic-derived cell lines (M4 Beu and M3 Dau). "
09/01/1989 - "Relationships among cell survival, O6-alkylguanine-DNA alkyltransferase activity, and reactivation of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines."

11/01/1991 - "O6-alkylguanine-DNA alkyltransferase activity in human brain tumors."
12/03/1990 - "The O6-alkylguanine-DNA alkyltransferase (AT) activity in different kinds of human brain tumors was investigated. "
12/03/1990 - "O6-alkylguanine-DNA alkyltransferase activity in human brain tumors."
01/01/1984 - "O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors."
09/01/2004 - "Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations."

04/01/2000 - "Studies with transgenic mice in which alkyltransferase levels are increased or decreased confirm the importance of this repair pathway in protecting against carcinogenesis. "
09/01/1994 - "Our data establish that rapid O6-methylguanine-DNA adduct repair due to enhanced levels of alkyltransferase in MGMT-CD2-transgenic mice blocks the initiation of MNU-induced carcinogenesis."
06/01/1994 - "Alkyltransferase transgenic mice: probes of chemical carcinogenesis."
03/01/2002 - "O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy."
01/01/1997 - "Esophageal carcinogenesis in the rat: zinc deficiency, DNA methylation and alkyltransferase activity."

09/01/1994 - "Previous studies have shown that single doses of MNU administered to adult mice induced thymic lymphomas in over 80% of mice, while transgenic mice expressing high levels of the human O6-alkylguanine-DNA alkyltransferase gene in the thymus (MGMT-CD2 transgenics) were protected from developing MNU-induced lymphomas. "
01/08/1993 - "The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase."
03/01/1995 - "Transgenic mice over-expressing MGMT, which codes for the human protein O6-alkylguanine-DNA alkyltransferase, are protected from methylating agent-induced thymic lymphomas. "
05/01/1995 - "Transgene expression was characterized by in situ hybridization for MGMT mRNA and immunohistochemistry for the human alkyltransferase protein and was compared to the phenotype of the MNU induced lymphomas. "
06/01/1994 - "Mice expressing the human alkyltransferase in the thymus have a reduced incidence of thymic lymphomas following exposure to methyl nitrosourea (MNU), evidence of a role for this DNA-repair protein in protection from carcinogenesis due to N-nitroso compounds. "