|1.||Decorti, Giuliana: 1 article (04/2015)|
|2.||Moressa, Valentina: 1 article (04/2015)|
|3.||Pastore, Serena: 1 article (04/2015)|
|4.||Zandonà, Luigi: 1 article (04/2015)|
|5.||Favretto, Diego: 1 article (04/2015)|
|6.||Stocco, Gabriele: 1 article (04/2015)|
|7.||Ventura, Alessandro: 1 article (04/2015)|
|8.||Malusà, Noelia: 1 article (04/2015)|
|9.||Lepore, Loredana: 1 article (04/2015)|
|10.||Weiler, Tracey: 1 article (08/2011)|
|1.||Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
08/01/2011 - "Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis."
04/01/2015 - "5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis."
|2.||Psoriasis (Pustulosis Palmaris et Plantaris)
07/01/1999 - "Methotrexate treatment of patients with psoriasis inhibits AICA ribotide transformylase and adenosine metabolism. "
02/01/2009 - "To assess if single nucleotide polymorphisms (SNPs) across four genes that are relevant to methotrexate metabolism [folypolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylenetetrahydrofolate reductase (MTHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC)] are related to treatment outcomes in patients with psoriasis. "
07/01/1999 - "We hypothesized that low-dose methotrexate treatment for patients with psoriasis would block purine biosynthesis at the step catalyzed by aminoimidazolecarboxamide (AICA) ribotide transformylase and would inhibit adenosine metabolism as evidenced by increased urinary levels of AICA and adenosine, respectively. "
06/01/1989 - "Compound 4 is a much weaker inhibitor of murine (L1210) and human (MOLT-4) leukemia cell GAR formyltransferases (IC50 greater than 1 x 10(-5) M). "
11/29/1994 - "5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors."
09/01/2004 - "Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis."
04/01/2009 - "In contrast, each weakly inhibits other enzymes of folate metabolism relevant to rheumatoid arthritis therapy (thymidylate synthase (EC 188.8.131.52), two formyltransferases of purine biosynthesis (EC 184.108.40.206 and EC 220.127.116.11), and 5,10-methylenetetrahydrofolate reductase (EC 18.104.22.168)). "
|5.||Venous Thrombosis (Deep-Vein Thrombosis)
|2.||Inosine Triphosphate (ITP)
|4.||Reduced Folate Carrier Protein
|5.||Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
|6.||Folic Acid (Vitamin M)
|7.||AICA ribonucleotide (CAIR)
|10.||Tissue Inhibitor of Metalloproteinases (TIMP)