Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia.
Also Known As:
MET Proto-Oncogene, Receptor Tyrosine Kinase; MET Receptor Tyrosine Kinase; Receptor, HGF; Receptor, Hepatocyte Growth Factor; Receptor, Scatter Factor; Scatter Factor Receptor; c-Met Receptor Tyrosine Kinase; MET Proto Oncogene, Receptor Tyrosine Kinase; Proto Oncogene Proteins c met; Proto-Oncogene Proteins, met; c Met Receptor Tyrosine Kinase; c met Proteins; met Proto Oncogene Proteins; HGF Receptor; Hepatocyte Growth Factor Receptor; c-met Proteins; met Proto-Oncogene Proteins