O(6)-Methylguanine-DNA Methyltransferase

An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC
Also Known As:
DNA Repair Methyltransferase I; DNA Repair Methyltransferase II; Guanine-O(6)-Alkyltransferase; O(6)-Alkylguanine-DNA Alkyltransferase; O(6)-MeG-DNA Methyltransferase; O(6)-Methylguanine DNA Transmethylase; Methylated DNA Protein Cysteine S Methyltransferase; S-Methyltransferase, Methylated-DNA-Protein-Cysteine; Methylated-DNA-Protein-Cysteine S-Methyltransferase; O(6)-AGT; O(6)-Methylguanine Methyltransferase; DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase
Networked: 228 relevant articles (11 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Weller, Michael: 12 articles (07/2014 - 09/2008)
2. Sartorelli, Alan C: 10 articles (05/2015 - 12/2008)
3. Shyam, Krishnamurthy: 10 articles (05/2015 - 12/2008)
4. Penketh, Philip G: 10 articles (05/2015 - 12/2008)
5. Baumann, Raymond P: 9 articles (05/2015 - 06/2010)
6. Wick, Wolfgang: 9 articles (07/2014 - 09/2008)
7. Kaina, Bernd: 9 articles (01/2013 - 03/2003)
8. Ishiguro, Kimiko: 8 articles (08/2014 - 12/2008)
9. Zhu, Rui: 7 articles (05/2015 - 05/2011)
10. Pegg, Anthony E: 7 articles (06/2009 - 04/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Glioblastoma (Glioblastoma Multiforme)
3. Glioma (Gliomas)
4. Pituitary Neoplasms (Pituitary Adenoma)
5. Astrocytoma (Pilocytic Astrocytoma)
06/01/2010 - "O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation is significantly less frequent in ependymal tumours as compared to malignant astrocytic gliomas."
01/01/2005 - "TP53 mutations are significantly more frequent in low-grade astrocytomas with promoter methylation of the O(6)-methylguanine-DNA methyltransferase repair gene, suggesting that, in addition to deamination of 5-methylcytosine, exogenous or endogenous alkylation in the O(6) position of guanine may contribute to the formation of these mutations."
02/01/2014 - "As the presence of the p.R132H mutation in the IDH1 gene seems to be a more powerful prognostic marker than O(6)-methylguanine-DNA methyltransferase promoter status, we evaluated the presence of IDH1 mutation in Polish patients with astrocytoma, glioblastoma, oligoastrocytoma, ganglioglioma, oligodendroglioma, and ependymoma. "
08/01/2007 - "Promoter methylation of the deoxyribonucleic acid (DNA) repair gene, O(6)-methylguanine-DNA methyltransferase (MGMT), is associated with improved outcome of patients with glioblastoma multiforme and anaplastic astrocytoma treated with temozolomide (TMZ). "
05/01/2011 - "This article provides an overview of the most common molecular markers in neurooncology, including 1p/19q codeletion in oligodendroglial tumors, mutations in the isocitrate dehydrogenase 1 and 2 genes in diffuse gliomas, hypermethylation of the O(6)-methylguanine-DNA methyltransferase gene promoter in glioblastomas and anaplastic gliomas, alterations in the epidermal growth factor receptor and phosphatase and tensin homolog genes in high-grade gliomas, as well as BRAF alterations in pilocytic astrocytomas. "

Related Drugs and Biologics

1. temozolomide (Temodar)
2. Alkylating Agents
3. Carmustine (FIVB)
4. DNA (Deoxyribonucleic Acid)
5. Guanine
6. Complement System Proteins (Complement)
7. O(6)-benzylguanine
8. death-associated protein kinase
9. Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Adjuvant Chemotherapy
4. Aftercare (After-Treatment)
5. Liver Transplantation