|3.||Habitual Abortion (Recurrent Miscarriage)
|5.||Venous Thrombosis (Deep-Vein Thrombosis)
|1.||Rosendaal, F R: 33 articles (09/2015 - 03/2000)|
|2.||Glueck, Charles J: 30 articles (12/2015 - 06/2002)|
|3.||Wang, Ping: 28 articles (12/2015 - 06/2002)|
|4.||Nielsen, Vance G: 23 articles (08/2015 - 10/2002)|
|5.||Martinelli, Ida: 20 articles (12/2015 - 05/2002)|
|6.||Rosendaal, Frits R: 18 articles (01/2015 - 01/2002)|
|7.||Mannucci, Pier Mannuccio: 17 articles (12/2015 - 05/2002)|
|8.||De Stefano, Valerio: 17 articles (02/2015 - 05/2002)|
|9.||Brenner, Benjamin: 17 articles (01/2014 - 02/2002)|
|10.||Bertina, R M: 16 articles (03/2008 - 03/2000)|
|1.||Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
01/01/2013 - "Retrospective case-control studies and recently published randomised controlled cohort studies have shown, that prophylactic administration of low-molecular-weight heparin (LWH), started in early pregnancy, may lead to a significant reduction in the incidence of PmC in subsequent pregnancies in patients with and without hereditary thrombophilias and previous PmC. "
03/01/2011 - "It remains a matter of debate if women with a previous history of (severe) P-EC should be screened for inherited thrombophilias and if the administration of low molecular weight heparin should be recommended in women with positive results to prevent adverse outcomes in subsequent pregnancies. "
10/01/2009 - "Preliminary nonrandomized studies suggest a benefit for prophylaxis with unfractioned and low-molecular-weight heparin (LMWH), and prospective randomized trials are in progress to define whether LMWH is effective in preventive pregnancy loss and other gestational vascular complications in women with thrombophilia and previus fetal wastage."
06/01/2003 - "Preliminary non-randomized studies suggest a benefit for prophylaxis with unfractionated and low-molecular-weight heparin (LMWH), and prospective randomized trials are in progress to define whether LMWH is effective in preventing pregnancy loss and other gestational vascular complications in women with thrombophilia and previous fetal wastage."
11/25/2002 - "Preliminary case-control studies suggest a benefit for prophylaxis with low molecular weight heparins (LMWH), and prospective randomized trials are in progress to define whether LMWH are effective in preventing pregnancy loss in women with thrombophilia and previous fetal wastage."
|2.||Heparin (Liquaemin)FDA LinkGeneric
12/01/2003 - "There is a dire lack of randomized trials in the literature on the efficacy of heparin or other coagulation modulators on pregnancy outcome in patients with inherited thrombophilias. "
06/01/2015 - " aim of this study was to evaluate the beneficial effects of heparin on ART outcomes in women with history of recurrent implantation failure (RIF) and without history of congenital or acquired thrombophilia in a randomized, controlled clinical trial (RCT). "
12/01/2006 - "Hence, a randomized double-blinded controlled trial is urgently needed to evaluate the benefit of heparin during pregnancy in women with a history of APO in association with thrombophilia."
11/01/2006 - "Hence, a randomized double-blind, controlled trial is urgently needed to evaluate the benefit of heparin during pregnancy in women with a history of adverse pregnancy outcome in association with genetic thrombophilia."
10/01/2006 - "Heparin seems to improve obstetrical prognosis for patients with congenital or acquired thrombophilias, but there are only few studies carried out on the subject. "
|3.||Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
07/01/2014 - "Such benefit is independent of the presence of inherited thrombophilias or the administration of low dose aspirin. "
05/15/2013 - "Aspirin insensitive thrombophilia: transcript profiling of blood identifies platelet abnormalities and HLA restriction."
09/01/2012 - "Markers of hypercoagulability, endothelial and platelet activation as related to RPR, were evaluated to explore the potential mechanisms behind high on-aspirin RPR. "
10/01/2007 - "However, hypercoagulability following OPCAB is still of concern, and acetylsalicylic acid as thromboembolic prophylaxis might be insufficient in the first weeks following OPCAB surgery. "
02/01/2003 - "The rationale for prescribing aspirin in cases of recurrent reproductive failure associated with APA seropositivity is that aspirin may counter APA-mediated hypercoagulability in the choriodecidual space, a situation which if left unaddressed would traumatize the trophoblast and compromise feto-maternal exchange. "
|4.||Biological Markers (Surrogate Marker)IBA
07/01/2012 - "The aim of this study was to evaluate ADAMTS13 and VWF plasma levels from patients undergoing HD as putative biomarkers of the hypercoagulability state, as well the association between these markers and VAT occurrence. "
01/01/2015 - "Inflammatory biomarkers predicting acute cardiac events and hypercoagulability with in vivo platelet activation were demonstrated in same-aged asymptomatic middle-aged men during marathons. "
12/01/2014 - "While some acquired and inherited thrombophilias have been associated with increased risk of incident and/or recurrent VTE and AIS, knowledge of other diagnostic and prognostic biomarkers of VTE/AIS in children remains quite limited. "
02/01/2014 - "Identification of clinical markers indicating a hypercoagulability state could define a group of high-risk patients in the surgical setting. "
01/01/2014 - "The incorporation of hypercoagulability biomarkers could increase the sensitivity of risk assessment models (RAM) to identify patients at VTE risk. "
|5.||Enoxaparin (Lovenox)FDA LinkGeneric
10/01/2012 - "Enoxaparin-based intervention using a score system in pregnant women with thrombophilia is effective in improving perinatal outcome."
10/01/2012 - "To assess whether an enoxaparin-based intervention using a score system was effective in improving perinatal outcome in women with thrombophilia. "
01/01/2001 - "These results suggest that enoxaparin adapted to the fertility program can be effective in the prevention of preclinical and clinical abortion in women with thrombophilia."
05/01/2000 - "Enoxaparin is safe and effective in prevention of pregnancy loss in women with inherited and acquired thrombophilia."
01/01/2001 - "We evaluated the efficacy of enoxaparin adapted to the fertility program for prevention of pregnancy loss in 35 women (W) with early RPL and thrombophilia. "
|6.||factor V LeidenIBA
01/01/2005 - "Who, what, and when to test continue to be controversial and challenging questions (2); however, laboratories developing new or improved mutation detection methodologies have used the most commonly screened inherited thrombophilia polymorphism, factor V Leiden (R506Q), for many years (3). "
03/16/2009 - "A heterozygotic mutation for factor V Leiden was found in a hypercoagulability study that was later performed. "
10/01/1996 - "The diagnostic strategies and clinical characteristics of thrombophilia associated with heterozygous or homozygous factor V Leiden mutation have been determined according to the literature and to a personal study in 51 families. "
10/03/2015 - "The thrombophilia workup revealed either the presence of congenital homozygous PC deficiency, prothrombotic polymorphisms (factor V Leiden and FIIG20210A heterozygosity), acquired PC/PS deficiency, or no discernible thrombophilia. "
09/01/2014 - "With the exception of factor V Leiden mutation, other types of congenital thrombophilia are almost negligible among older women. "
09/01/2012 - "Observational studies indicate that anticoagulants are equally effective in patients with and without thrombophilia; therefore, the presence of thrombophilia should not influence the choice of anticoagulant or the intensity of therapy. "
11/01/2002 - "Determination of the hypercoagulability marker F1+2 might result in greater efficacy and safety for the use of oral anticoagulants, resulting in improved quality of life for patients."
07/01/2014 - "Documentation of an association between the risk of such adverse pregnancy outcomes (APOs) and inherited thrombophilias prompted initial studies to evaluate the benefit of anticoagulants for the prevention of recurrences both in patients with and without inherited thrombophilias. "
02/01/2014 - "The results of the use of anticoagulants for treating RPL in women with inherited thrombophilia (IT) are encouraging, but recently four major multicentre studies have shown that fetal outcomes (determined by live birth rates) may not be as favourable as previously suggested. "
01/01/2014 - "Further work in larger studies should define the clinical consequences of identifying hypercoagulability and a possible role for very early, targeted use of anticoagulants."
04/01/2012 - "Clinical audit of antiphospholipid antibody testing in tertiary practice: towards improved relevance in thrombophilia investigations."
03/01/2009 - "In addition to being markers for thrombotic risk, antiphospholipid antibodies have been shown to directly contribute to hypercoagulability in animal models and in various in vitro studies. "
04/01/2003 - "Most of the Doppler studies of the umbilical and uterine arteries in pregnancies with thrombophilia were performed in women with antiphospholipid antibodies. "
08/01/1994 - "To study neuroradiologic findings in patients with hypercoagulability due to antiphospholipid antibodies (APAs). "
10/01/2014 - "A thorough thrombophilia screen confirmed the presence of antiphospholipid antibodies. "
|9.||Prothrombin (Factor II)IBA
12/01/2014 - "The aim of this study was to screen the 3' end of the prothrombin (FII) gene, which is susceptible to gain-of-function mutations due to its non canonical architecture, in patients with idiopathic thrombophilia and to determine its eventual role in the pathogenesis of thrombophilia. "
01/01/2014 - "None of the meta-analyses identified any thrombophilia to be predictive of PTS. Both FVL and prothrombin mutation appeared protective among studies including patients with both first and recurrent DVT and studies in which more than 50% of patients had an unprovoked DVT. "
01/01/2012 - "In the presence of CVST must be considered the primary studies for thrombophilia gene mutations, including prothrombin G20210A."
01/15/2004 - "Further studies are needed to define the value of additional prothrombin 19911 genotyping for thrombophilia screening, especially in cases heterozygous for 20210G>A."
09/01/2015 - "Prothrombin (F2) 20210G>A [rs1799963 G>A] mutation is a genetic variant which predisposes to inherited thrombophilia. "
11/01/2012 - "A thoroughly validated computational model was used to simulate thrombin generation curves for 472 healthy subjects in the Leiden Thrombophilia Study. "
08/01/2012 - "We used a thoroughly validated computational model to simulate thrombin generation in normal and diluted blood for 472 healthy subjects in the control group of the Leiden Thrombophilia Study. "
08/31/1979 - "This study reports the correlation of the thrombin generation test and the plasma clot impedance test with clinical evidence of hypercoagulability. "
12/01/2015 - "Thrombin generation and international normalized ratio in inherited thrombophilia patients receiving thromboprophylactic therapy."
10/01/2015 - "These data suggest a clinically relevant link between complement activation and thrombin generation and offer a potential mechanism underlying ATG-induced hypercoagulability. "
|1.||Hormone Replacement Therapy (Therapy, Hormone Replacement)
01/01/1998 - "Whether women with thrombophilia are at increased risk for VTE when they use hormone replacement therapy (HRT) has not been assessed in any study. "
02/01/2009 - "Assessment of hypercoagulability markers and lipid levels in postmenopausal women undergoing either oral or transdermal hormone replacement therapy."
09/01/2007 - "Universal screening for thrombophilia before prescribing hormone replacement therapy might be cost-effective. "
06/01/2005 - "This article gives estimates of the absolute risk of using hormone replacement therapy and practical advice on its use in these groups and on the role of thrombophilia screening."
03/01/2005 - "The complications of hormone replacement therapy (HRT) related to hypercoagulability are well known. "
10/01/2011 - "In patients undergoing total hip or total knee arthroplasty (THA or TKA, respectively), different patterns of altered venous hemodynamics and hypercoagulability have been found, thus the rate of distal DVT is higher than that of proximal DVT after TKA. "
08/01/2009 - "Heritable thrombophilia has been studied in relation to numerous clinical conditions, and it has been associated with thromboembolic complications after some orthopaedic surgeries, especially after total hip or knee arthroplasty. "
12/01/2005 - "The John Charnley Award: heritable thrombophilia and development of thromboembolic disease after total hip arthroplasty."
01/01/2005 - "Albumin induced hypercoagulability does not reduce blood loss in patients undergoing total hip arthroplasty."
08/01/1999 - "[Persistence of hypercoagulability state after hip and knee arthroplasty: what is the optimal duration of antithrombotic guidelines in this surgery?]."
01/01/2009 - "Thrombophilia and pulmonary endarterectomy."
12/01/1998 - "Pulmonary thromboendarterectomy under deep hypothermic intermittent circulatory arrest was effective for chronic pulmonary thromboembolism accompanied by thrombophilia for which medical treatment is of limited value."
01/01/2009 - "In the present study, we compared groups of patients with and without thrombophilia, who underwent pulmonary endarterectomy (PEA), definitive treatment for chronic pulmonary hypertension resulting from thromboembolic disease. "
02/01/2006 - "Pulmonary thromboendarterectomy was performed on a patient with chronic pulmonary thromboembolism showing thrombophilia. "
12/01/1998 - "We have performed pulmonary thromboendarterectomy on 8 patients with chronic pulmonary thromboembolism accompanied by thrombophilia. "
08/01/2013 - "Intraoperative hypercoagulability during liver transplantation as demonstrated by thromboelastography."
04/15/2009 - "The impact of inherited thrombophilia on liver transplantation."
04/01/2005 - "We described a case of thrombophilia acquired due to liver transplantation from a donor with heritable thrombophilia."
03/01/2011 - "Donor screening algorithm for exclusion of thrombophilia during evaluation of living donor liver transplantation."
11/01/2004 - "Liver transplantation for type 1 primary hyperoxaluria as a cure for combined thrombophilia."
|5.||Free Tissue Flaps
09/01/2015 - "Thrombophilia uncovered by microvascular procedures can be effectively treated with anticoagulation upon discovery and prevent postoperative free flap thrombotic events. "
12/01/2013 - "A review of the literature will be presented, and published cases of free-flap failure in patients with thrombophilia(s) will be summarized."
12/01/2013 - "Free-flap failure in thrombophilia: case report and systematic review of the literature."
06/01/2012 - "However, undiagnosed thrombophilias have been associated with microsurgery free flap failures. "
02/01/2012 - "Forty-one patients or 58 free flaps (2.9 percent) were identified as having a diagnosed thrombophilia or previous thromboembolic event. "