Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)

A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Also Known As:
Ryanodine Receptor; Ca Release Channel-Ryanodine Receptor; Receptor, Ryanodine; RyR2; RyR3; Ca Release Channel Ryanodine Receptor; Calcium Ryanodine Receptor Complex; Complex, Calcium-Ryanodine Receptor; Receptor 1, Ryanodine; Receptor 2, Ryanodine; Receptor 3, Ryanodine; Receptor Complex, Calcium-Ryanodine; Receptors, Ryanodine; Calcium-Ryanodine Receptor Complex; RyR1; Ryanodine Receptor 1; Ryanodine Receptor 2; Ryanodine Receptor 3; Ryanodine Receptors
Networked: 1176 relevant articles (18 outcomes, 96 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Marks, Andrew R: 45 articles (11/2015 - 01/2002)
2. Wehrens, Xander H T: 43 articles (12/2015 - 05/2003)
3. Chen, S R Wayne: 26 articles (10/2015 - 08/2002)
4. Dirksen, Robert T: 26 articles (01/2015 - 07/2002)
5. Reiken, Steven: 24 articles (11/2015 - 01/2002)
6. Treves, Susan: 23 articles (08/2015 - 01/2003)
7. Jungbluth, Heinz: 23 articles (08/2015 - 06/2002)
8. Ikemoto, Noriaki: 23 articles (12/2012 - 01/2002)
9. Muntoni, Francesco: 21 articles (08/2015 - 10/2004)
10. Lai, F Anthony: 20 articles (11/2015 - 09/2003)

Related Diseases

1. Heart Failure
2. Cardiac Arrhythmias (Arrythmia)
04/09/2010 - "In conclusion, CPVT mutation causes defective inter-domain interaction, significant reduction in the ability of CaM binding to the RyR2, spontaneous Ca(2+) leak, and then lethal arrhythmia."
01/01/2010 - "Monophasic action potential recordings demonstrated significantly greater incidences of arrhythmia in RyR2(p/s) and RyR2(s/s) hearts as compared to WTs. "
01/01/2006 - "The knowledge gained from various studies of ryanodine receptors under pathologic conditions might lead to the development of new pharmacological or genetic strategies for the treatment of HF or cardiac arrhythmia. "
11/17/2015 - "The model yields several predictions: 1) [ROS] is produced locally near the RyR2 complex during X-ROS signaling and increases by an order of magnitude more than the global ROS signal during myocyte stretching; 2) X-ROS activation just before the action potential, corresponding to ventricular filling during diastole, increases the magnitude of the Ca(2+) transient; 3) during prolonged stretching, the X-ROS-induced increase in Ca(2+) spark rate is transient, so that long-sustained stretching does not significantly increase sarcoplasmic reticulum Ca(2+) leak; and 4) when the chemical reducing capacity of the cell is decreased, activation of X-ROS signaling increases sarcoplasmic reticulum Ca(2+) leak and contributes to global oxidative stress, thereby increases the possibility of arrhythmia. "
03/15/2015 - "Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart."
3. Sudden Death
4. Malignant Hyperthermia
5. Central Core Myopathy (Central Core Disease)

Related Drugs and Biologics

1. tacrolimus binding protein 1B
2. K201 compound
3. Calcium
4. L-Type Calcium Channels (Dihydropyridine Receptor)
5. Tacrolimus Binding Proteins (FKBP)
6. Peptides
7. NADPH Oxidase (NAD(P)H oxidase)
8. Creatine Kinase (Creatine Phosphokinase)
9. acetovanillone (apocynin)
10. AICA ribonucleotide (CAIR)

Related Therapies and Procedures

1. Artificial Respiration (Mechanical Ventilation)
2. Positive-Pressure Respiration (PEEP)
3. Resuscitation
4. Anesthesia
5. Ligation