Genistein

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

Also Known As:

Networked: 2869 relevant articles (264 outcomes, 715 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sarkar, Fazlul H: 45 articles (01/2014 - 01/2002)
2.	Kucuk, Omer: 26 articles (01/2019 - 06/2002)
3.	Li, Yiwei: 24 articles (01/2014 - 01/2002)
4.	Helferich, William G: 20 articles (02/2020 - 05/2002)
5.	Lamartiniere, Coral A: 20 articles (05/2017 - 01/2002)
6.	Squadrito, Francesco: 19 articles (06/2017 - 10/2002)
7.	Al-Nakkash, Layla: 18 articles (01/2022 - 09/2009)
8.	Doerge, Daniel R: 18 articles (02/2020 - 05/2002)
9.	Bitto, Alessandra: 18 articles (06/2017 - 04/2004)
10.	Altavilla, Domenica: 16 articles (06/2017 - 10/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/27/2014 - "Proliferation of different human cancer cell lines, antimicrobial activity and angiogenesis behavior was analyzed in order to see if complexation has a beneficial effect for any of the above mentioned activities and if so, which of the three CDs is the most suitable for the incorporation of genistein, and which may lead to future improved pharmaceutical formulations. " 05/01/2005 - "Administration of 250 and 500 mg genistein/kg AIN-76A improved survival (P = 0.008 and P = 0.005, respectively) and reduced mean weight of prostates with poorly differentiated cancer (PD) (P < 0.001), as well as the mean weight of periaortic lymph nodes (LN), although the latter was not significant. " 03/01/2005 - "Treatment of ovariectomized Min/+ (Min/+ OX) mice with genistein resulted in a non-significant reduction in tumor number. " 10/01/2004 - "Genistein combined with radiation caused a significantly greater inhibition of primary tumor growth (87%) compared with genistein (30%) or radiation (73%) alone. " 09/01/2018 - "Genistein isolated from leguminous plants has been shown to be effective in oxidation resistance and tumor inhibition. "
2.	Breast Neoplasms (Breast Cancer) 11/14/2019 - "Herein we report the synthesis, a selective detailed characterization and preliminary in vitro/in vivo biological evaluation of genistein-IR 783 conjugate 4. The conjugate 4 displayed improved potency against human breast cancer MCF-7 cells (10.4 ± 1.0 μM) as compared with the parent genistein (24.8 ± 0.5 μM) or IR 783 (25.7 ± 0.7 μM) and exhibited selective high uptake in MCF-7 as against the normal mammary gland MCF-10A cells in various assays. " 08/01/2000 - "Dietary intake of genistein in combination with EPA may be beneficial for breast cancer control." 08/01/2000 - "We review data relevant to attempts to determine whether soy, and more specifically genistein, is a dietary component that may help to explain the dramatic disparity in breast cancer risk among these populations." 01/01/1999 - "Our results demonstrate in the rat that postnatal exposure to physiological concentrations of genistein in the diet is a safe and effective means of programming against chemically induced mammary cancer." 01/01/2022 - "Our study focused on a bioactive dietary component, genistein (GE) enriched in soybean products, to investigate specific timing of maternal GE exposure that may influence preventive efficacy of GE on offspring breast cancer later in life, and to explore the potential epigenetic mechanisms. "
3.	Insulin Resistance 01/01/2013 - "Better understanding of genistein action in regulation of insulin sensitivity in the endothelium could be beneficial for its possible applications in controlling endothelial dysfunction associated with diabetes and insulin resistance." 04/01/2011 - "It was concluded that insulin resistance induced by FFAs in HepG2 hepatocytes could be improved by genistein. " 11/01/2012 - "In this study, we hypothesized that supplemental genistein has beneficial effects on insulin resistance in an ovariectomized rat model by modulating lipid metabolism. " 01/01/2008 - "The study shows that genistein improves insulin sensitivity and kidney function in a dietary model of insulin resistance. " 12/01/2020 - "MC and Genistein significantly decreased (p < 0.05) homeostatic model assessment-insulin resistance (HOMA-IR) level compared with the diabetic control group. "
4.	Prostatic Neoplasms (Prostate Cancer) 08/16/2021 - "Preliminary in-vitro studies indicate that TGE exhibits higher cytotoxic activity towards DU145 human prostate cancer cells and is safer for normal prostate epithelial cells (PNT2) than genistein itself." 01/01/2019 - "Further studies as in vivo would be necessary to remove shadows on the effect of genistein on prostate cancer progression." 07/01/2017 - "In spite of numerous studies to understand the effects of genistein on prostate cancer, the mechanisms of action have not been fully elucidated. " 06/01/2015 - "Our study suggested that high concentration of plasma genistein level may contribute to the low incidence of prostate cancer in Chinese population." 06/01/2015 - "There were studies proving that high-dietary intake of genistein may relate to the low morbidity and mortality of prostate cancer (PCa) in the Asian population. "
5.	Inflammation (Inflammations) 06/01/2020 - "Genistein and moderate intensity exercise were effective in reducing the severity of NASH in OVX rats through the reduction in liver inflammation, oxidative stress and liver fat contents." 02/24/2022 - "Genistein-rich compounds provide protection against UVB-induced inflammation, as determined using in vitro and in vivo animal model experiments." 02/24/2022 - "The aim of this study was to clarify the effects of genistein on skin inflammation and photoaging by using 3 models (humans: skin parameters; animals: wrinkle formation; and cells: anti-inflammatory effects). " 11/01/2021 - "Therefore, this study investigated the effects of genistein, swimming exercise, and their co-treatment on retina angiogenesis, oxidative stress, and inflammation in diabetic-ovariectomized rats. " 10/01/2021 - "This study aimed to examine the possible preventive effect of MET in combination with genistein on skeletal muscle inflammation in high-fat diet (HFD) fed C57BL/6 mice. "

Related Drugs and Biologics

1.	Isoflavones
2.	daidzein
3.	Phytoestrogens (Phytoestrogen)
4.	Glucose (Dextrose)
5.	Resveratrol
6.	Quercetin
7.	Proteins (Proteins, Gene)
8.	epigallocatechin gallate (epigallocatechin-3-gallate)
9.	Curcumin
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Chemoprevention
5.	Ovariectomy (Oophorectomy)