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Simvastatin (Zocor)

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
Also Known As:
Zocor; MK-733; Synvinolin; MK 733; MK733
Networked: 4924 relevant articles (578 outcomes, 1572 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Wachtell, Kristian: 41 articles (01/2022 - 04/2007)
2. Gerdts, Eva: 40 articles (01/2021 - 04/2007)
3. Pedersen, Terje R: 38 articles (12/2019 - 01/2003)
4. Boman, Kurt: 33 articles (12/2019 - 04/2007)
5. Tershakovec, Andrew M: 32 articles (10/2021 - 10/2006)
6. Ray, Simon: 32 articles (01/2021 - 04/2007)
7. Cramariuc, Dana: 26 articles (01/2021 - 02/2008)
8. Rossebø, Anne B: 25 articles (01/2022 - 04/2007)
9. Ballantyne, Christie M: 24 articles (12/2016 - 06/2003)
10. Blazing, Michael A: 23 articles (10/2021 - 11/2003)

Related Diseases

1. Hypercholesterolemia
2. Hyperlipidemias (Hyperlipidemia)
3. Dyslipidemias (Dyslipidemia)
4. Inflammation (Inflammations)
5. Atherosclerosis

Related Drugs and Biologics

1. Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
2. Atorvastatin (Lipitor)
3. Lipids
4. Ezetimibe (Zetia)
5. Cholesterol
6. Pravastatin (Pravachol)
7. LDL Cholesterol
8. Rosuvastatin Calcium (Crestor)
9. oxidized low density lipoprotein
10. Simvastatin Drug Combination Ezetimibe (Vytorin)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Continuous Ambulatory Peritoneal Dialysis (CAPD)
4. Secondary Prevention
5. Ligation