Myristic Acid (Tetradecanoic Acid)

A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed)

Also Known As:

Networked: 249 relevant articles (5 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Akiyama, Kohki: 2 articles (12/2022 - 10/2020)
2.	Kameoka, Hiromu: 2 articles (12/2022 - 10/2020)
3.	Kawaguchi, Masayoshi: 2 articles (12/2022 - 10/2020)
4.	Saito, Katsuharu: 2 articles (12/2022 - 10/2020)
5.	Tanaka, Sachiko: 2 articles (12/2022 - 10/2020)
6.	Yano, Koji: 2 articles (12/2022 - 10/2020)
7.	Curi, Rui: 2 articles (01/2022 - 01/2021)
8.	Godoy, Guilherme: 2 articles (01/2022 - 01/2021)
9.	Snider, Ashley J: 2 articles (07/2021 - 10/2018)
10.	Amiano, Pilar: 2 articles (04/2021 - 10/2014)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2014 - "This growth inhibition was partially rescued by addition of the FFA, myristic acid, indicating the importance of FFA in cancer metabolism. " 01/01/1985 - "Comparison of the amount of [3H]myristic acid-labeled p60src in total cell lysates and in immunoprecipitates suggests that immunoprecipitation with rabbit anti-Rous sarcoma virus tumor sera detects ca. 25% of the p60src present in cells." 03/31/2023 - "To improve tumor targeting ability, we modified CS-piscidin by adding a short cyclic peptide, cyclo-RGDfk, to the C-terminus (CS-RGD) and a myristate to the N-terminus (Myr-CS-RGD). " 03/31/2023 - "Antimicrobial peptides CS-piscidin-induced cell death involves activation of RIPK1/PARP, and modification with myristic acid enhances its stability and tumor-targeting capability." 06/13/2018 - "Herein, we designed a myristic acid modified DA7R ligand (MC-DA7R), which combines tumor-homing DA7R with BBB-penetrable MC. "
2.	Infections 05/01/1991 - "Our previous studies suggested that myristic acid plays a role in poliovirus assembly and in the early events of infection. " 10/13/2020 - "Only myristate (C14:0) led to an increase in the biomass of Rhizophagus irregularis, inducing extensive hyphal growth and formation of infection-competent secondary spores. " 09/01/1996 - "Thus, VSG myristoylation by free myristate may be favoured in bloodstream trypanosome infections." 09/01/1990 - "The results suggest that VP0 myristoylation plays a role in the late steps of poliovirus assembly and that the myristate moiety of VP4 may be required in the early steps of poliovirus infection." 12/06/1994 - "They are killed at 37 degrees C when placed in medium lacking myristate and, in an immunosuppressed animal model of cryptococcal meningitis, are completely eliminated from the subarachnoid space within 12 days of initial infection. "
3.	Sepsis (Septicemia) 04/16/2021 - "Most patients with sepsis and SIRS had the highest levels of myristic acid within 24 h after an established diagnosis. " 04/16/2021 - "The myristic acid levels in the Sepsis Group and SIRS Group were found to be significantly higher when compared to healthy controls. " 04/16/2021 - "Myristic Acid Serum Levels and Their Significance for Diagnosis of Systemic Inflammatory Response, Sepsis, and Bacteraemia." 04/16/2021 - "Myristic acid should be considered as a new candidate marker of severe inflammation and sepsis. " 11/01/2019 - "Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study."
4.	Hemolysis 01/01/1989 - "(iv) Tetradecanoic acid (C14) exhibits two concentration ranges of protection against hypo-osmotic haemolysis, each followed by haemolytic concentrations. " 02/01/1996 - "When fractions of saturated fatty acids were studied, myristic acid (C14:0) increased markedly in the alcoholic group, and the increase was striking particularly in the cases of alcoholic hepatitis concurrently with hemolysis. " 10/06/1988 - "The results are summarized as follows: (A) the fatty acids examined exhibit a high degree of specificity in their thermotropic behavior; (B) oleic acid protects against hypotonic hemolysis even at the highest concentrations, up to 15 degrees C, when it becomes hemolytic, but only in a limited concentration range; (C) elaidic acid does not affect the osmotic stability of erythrocytes up to 20 degrees C, when it starts protecting: above 30 degrees C, it becomes hemolytic at the highest concentrations; (D) palmitoleic acid is an excellent protecting agent at all temperatures in a certain concentration range, becoming hemolytic at higher concentrations; (E) lauric acid protects up to 30 degrees C and becomes hemolytic only above this temperature; (F) myristic acid exhibits an extremely unusual behavior at 30 and 37 degrees C by having alternating concentration ranges of protecting and hemolytic effects; (G) there is a common critical temperature for hemolysis at 30 degrees C for saturated and trans-unsaturated fatty acids; (H) the initial slope of Arrhenius plots of percent hemolysis at the concentration of maximum protection is negative for cis-unsaturated fatty acids and positive for saturated and trans-unsaturated fatty acids." 08/01/1992 - "The effects, at pH 7.0, of a series of 0.2 mM phosphatidylcholines (PC), namely dicaproyl-PC (DCPC), didecanoyl-PC (DDPC), dilauroyl-PC (DLaPC), dimyristoyl-PC (DMPC), dipalmitoyl-PC (DPPC), dioleoyl-PC (DOPC) and dilinoleoyl-PC (DLPC) and a series of 0.2 mM fatty acid salts (namely sodium myristate, palmitate, stearate, oleate and linoleate) upon the erythrocyte haemolysis induced by 2 mM sodium taurodeoxycholate (STDC) were determined. "
5.	Stroke (Strokes) 01/01/2015 - "The results suggest that CVD risk factors are more extensively affected by individual FAs than hitherto recognized, and that risk for CVD, MI and stroke can be reduced by reducing the intake of palmitate, myristic acid and simple carbohydrates and improved by greater intake of linoleic acid and marine n-3 FAs." 01/01/2020 - "After analyzing those 12 differential urinary metabolites by step-wise logistic regression analysis, only seven metabolites (palmitic acid, hydroxylamine, myristic acid, glyceric acid, lactic acid, tyrosine and azelaic acid) were finally selected as potential biomarkers for diagnosing PSD in middle-aged stroke survivors. " 01/01/2022 - "Random-effects or fixed-effects models was used to estimate the pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) for the association of total or individual SFA biomarkers, including even-chain SFAs (e.g., 14:0, myristic acid; 16:0, palmitic acid; 18:0, stearic acid), odd-chain SFAs (e.g., 15:0, pentadecanoic acid; 17:0, margaric acid) and very-long-chain SFAs (VLCSFAs; e.g., 20:0, arachidic acid; 22:0, behenic acid; 24:0, lignoceric acid), with risk of incident type 2 diabetes (T2D), cardiovascular disease [CVD; coronary heart disease (CHD) inclusive of stroke], CHD and stroke. "

Related Drugs and Biologics

1.	Acetates (Acetic Acid Esters)
2.	Palmitates
3.	Linoleic Acid (Linoleate)
4.	Lipopolysaccharides
5.	anthracene
6.	Carbohydrates
7.	phorbol
8.	Palmitic Acid (Hexadecanoic Acid)
9.	Phorbol Esters
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Therapeutics
3.	Highly Active Antiretroviral Therapy (HAART)
4.	Microspheres (Microsphere)
5.	Aftercare (After-Treatment)