|1.||Neuzil, Jiri: 35 articles (04/2015 - 05/2004)|
|2.||Wu, Kun: 18 articles (10/2015 - 02/2002)|
|3.||Dong, Lan-Feng: 18 articles (04/2015 - 05/2006)|
|4.||Volchegorskiĭ, I A: 13 articles (01/2014 - 01/2004)|
|5.||Puri, Prem: 13 articles (10/2013 - 10/2002)|
|6.||Zhao, Yan: 12 articles (09/2014 - 02/2002)|
|7.||Tomasetti, Marco: 11 articles (10/2015 - 05/2004)|
|8.||Ralph, Stephen J: 11 articles (02/2014 - 02/2007)|
|9.||Stursa, Jan: 9 articles (04/2015 - 02/2011)|
|10.||Goodwin, Jacob: 9 articles (04/2015 - 03/2009)|
12/10/2014 - "Bt modifies the metabolite environment at infection sites, increasing metabolites involved in gluconeogenesis, with stark increases in succinate, which can be sensed by Cra. "
12/01/2007 - "To investigate the influence of succinic acid on the apoptosis of polymorphonuclear neutrophil (PMN) in human peripheral blood, and to explore its role in infection. "
02/01/2004 - "To explore the mechanism of injurious effect of succinic acid on human fibroblast and it's role in bacteroides fragilis infection. "
05/01/1985 - "These findings suggest that succinic acid may be an important Bacteroides virulence factor when present in the microenvironment of a mixed intra-abdominal infection in which concentrations are high and the pH of the medium is reduced."
05/01/1985 - "Succinic acid, a major fatty acid by-product of Bacteroides metabolism, was tested for its effect on neutrophil function to determine whether it might play a role in enhancing the virulence of Bacteroides-containing infections. "
11/01/2012 - "Recently, several studies revealed that alpha-tocopheryl succinate (αTP-suc) have demonstrated potent anti-cancer activities in vitro and in vivo. "
02/01/2011 - "Previous studies of the cytotoxic effects of α-tocopheryl succinate (α-TOS) on cancer cells identified a mechanism whereby α-TOS caused apoptosis requiring the Noxa-Bak axis. "
03/01/2009 - "The purpose of this study was to elucidate the cellular target by which these agents, represented by alpha-tocopoheryl succinate (alpha-TOS), suppress tumors in vivo, with the focus on the mitochondrial complex II (CII). "
01/01/2009 - "Preclinical investigations have suggested that VE succinate (VES) is the most effective analog of VE in cancer cells; however, no study of VES in RCC has been done. "
08/01/2002 - "The purpose of this study was to measure and compare the effect of d-alpha-tocopheryl succinate (alpha-TS) in modifying radiation-induced chromosomal damage in human normal cells and cancer cells in culture. "
11/01/2013 - "According to the findings of the study, succinic acid at the concentrations ranging between 31.25 mg x L(-1) and 500 mg x L(-1) had no significant effect on primary cardiomyocyte activity, and succinic acid at the concentrations of 400, 200, 100, 50 mg x L(-1) could notably reduce cardiomyocyte ischemia/reperfusion LDH leakage rate (P < 0.01 or P < 0.05, respectively). "
01/01/2014 - "Because some pathological conditions such as ischemia increase succinate blood levels, we investigated the role of this metabolite during a heart ischemic event, using human and rodent models. "
01/01/2014 - "It was established that the derivatives of 3-oxipiridine and succinic acid protected against subtotal ischemia of rostral brain segments (of cerebral hemispheres) as evidenced by the increase in longevity. "
03/01/2013 - "Succinate accumulates during ischemia to become the major substrate utilized by cardiac mitochondria. "
08/01/2007 - "Ischemia induced release of succinate in isolated perfused livers. "
|4.||Urinary Tract Infections (Urinary Tract Infection)
03/01/2011 - "An algorithm for imaging of infants with first time urinary tract infection based on these results would have eliminated 126 acute dimercapto-succinic acid scans compared to our study protocol, while missing 9 patients with permanent renal damage. "
07/01/2010 - "The main study end points were recurrent febrile urinary tract infection, renal status on dimercapto-succinic acid scintigraphy and reflux status. "
05/01/2014 - "Cox regression analysis revealed that a normal initial dimercapto-succinic acid scan, initial reflux grade less than 5 and absent breakthrough febrile urinary tract infections were predictive of reflux resolution/improvement (p <0.05). "
05/01/2014 - "Variables of interest included presentation, dimercapto-succinic acid results, sex, breakthrough febrile urinary tract infections, reflux grade and bilateral reflux. "
02/01/2012 - "A postoperative decrease in differential renal function without further urinary tract infection could develop when there is a parenchymal reduction on preoperative dimercapto-succinic acid scan."
12/01/2015 - "Succinate: A Promising Therapeutic Target for Reperfusion Injury."
11/20/2014 - "Furthermore, these findings reveal a new pathway for metabolic control of ROS production in vivo, while demonstrating that inhibition of ischaemic succinate accumulation and its oxidation after subsequent reperfusion is a potential therapeutic target to decrease ischaemia-reperfusion injury in a range of pathologies. "
11/20/2014 - "Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS."
01/01/1998 - "Cardioprotective effect of succinate against ischemia/reperfusion injury."
01/01/1998 - "We investigated the protective effects of succinate, which is a respiratory substrate and a potential antioxidant, on myocardial ischemia/reperfusion injury with the whole heart. "
|4.||Polyethylene Glycols (Polyethylene Glycol)
|8.||alpha-tocopheryl polyethylene glycol succinate
|1.||Drug Therapy (Chemotherapy)
|3.||Extracorporeal Membrane Oxygenation (ECMO)