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2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)

A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Also Known As:
2,3 Bisphosphoglycerate; 2,3 Diphosphoglycerate; 2,3-Diphosphoglycerate, (D)-Isomer; Glycerate 2,3-Bisphosphate; 2,3 Diphosphoglyceric Acid; 2,3-Bisphosphate, Glycerate; 2,3-Bisphosphoglycerate; 2,3-DPG; 2,3-Diphosphoglyceric Acid
Networked: 512 relevant articles (4 outcomes, 35 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Cardigan, Rebecca: 6 articles (01/2022 - 12/2008)
2. D'Alessandro, Angelo: 4 articles (01/2020 - 10/2016)
3. Xia, Yang: 4 articles (01/2020 - 10/2016)
4. Acker, Jason P: 4 articles (08/2018 - 10/2014)
5. Meli, Athinoula: 3 articles (01/2022 - 01/2018)
6. New, Helen V: 3 articles (01/2022 - 01/2019)
7. Wiltshire, Michael: 3 articles (01/2022 - 12/2010)
8. Song, Anren: 3 articles (01/2020 - 10/2016)
9. Holovati, Jelena L: 3 articles (08/2018 - 05/2015)
10. Gulliksson, H: 3 articles (01/2017 - 04/2009)

Related Diseases

1. Hypoxia (Hypoxemia)
2. Hemolysis
3. Body Weight (Weight, Body)
4. Chronic Obstructive Pulmonary Disease (COPD)
5. Anemia

Related Drugs and Biologics

1. Oxygen (Dioxygen)
2. Adenosine Triphosphate (ATP)
3. Phosphates (Orthophosphate)
4. purine
5. Lipids
6. Adenosine (Adenocard)
7. Retinaldehyde (Retinal)
8. Hemoglobins (Hemoglobin)
9. Potassium
10. Glucose (Dextrose)

Related Therapies and Procedures

1. Therapeutics
2. Renal Dialysis (Hemodialysis)
3. Splenectomy
4. Total Parenteral Nutrition
5. Blood Transfusion (Blood Transfusions)