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2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)

A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Also Known As:
2,3 Bisphosphoglycerate; 2,3 Diphosphoglycerate; 2,3-Diphosphoglycerate, (D)-Isomer; Glycerate 2,3-Bisphosphate; 2,3 Diphosphoglyceric Acid; 2,3-Bisphosphate, Glycerate; 2,3-Bisphosphoglycerate; 2,3-DPG; 2,3-Diphosphoglyceric Acid
Networked: 398 relevant articles (2 outcomes, 26 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. de Korte, Dirk: 2 articles (07/2015 - 06/2008)
2. Acker, Jason P: 2 articles (05/2015 - 10/2014)
3. Kaminsky, Yury G: 2 articles (02/2014 - 01/2013)
4. Aliev, Gjumrakch: 2 articles (02/2014 - 01/2013)
5. Reddy, V Prakash: 2 articles (02/2014 - 01/2013)
6. Kosenko, Elena A: 2 articles (02/2014 - 01/2013)
7. Carreras, José: 2 articles (03/2011 - 01/2004)
8. Climent, Fernando: 2 articles (03/2011 - 01/2004)
9. Detry, Bruno: 2 articles (12/2008 - 11/2002)
10. Aydońüan, S: 1 article (08/2015)

Related Diseases

1. Anoxia (Hypoxia)
2. Hemolysis
3. Chronic Obstructive Pulmonary Disease (COPD)
4. Anemia
5. Acidosis

Related Drugs and Biologics

1. Oxygen
2. purine
3. Phosphates
4. Retinaldehyde (Retinal)
5. Hemoglobins (Hemoglobin)
6. Adenosine Triphosphate (ATP)
7. Glucose (Dextrose)
8. Potassium
9. Oxyhemoglobins (Oxyhemoglobin)
10. Methemoglobin

Related Therapies and Procedures

1. Renal Dialysis (Hemodialysis)
2. Splenectomy
3. Total Parenteral Nutrition
4. Dilatation and Curettage (D&C)
5. Blood Transfusion (Blood Transfusions)