CXC Chemokines

Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.

Also Known As:

Chemokines, CXC; C-X-C Chemokines; C X C Chemokine; Chemokine, C-X-C; Chemokine, CXC; Chemokines, C-X-C; alpha Chemokine; alpha Chemokines; C-X-C Chemokine; CXC Chemokine; alpha-Chemokine; alpha-Chemokines

Networked: 2031 relevant articles (31 outcomes, 241 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Strieter, Robert M: 33 articles (03/2011 - 06/2002)
2.	Thorlacius, Henrik: 29 articles (11/2021 - 05/2003)
3.	Antonelli, Alessandro: 24 articles (01/2019 - 11/2004)
4.	Fallahi, Poupak: 24 articles (01/2019 - 11/2004)
5.	Ferrari, Silvia Martina: 24 articles (01/2019 - 11/2004)
6.	Burdick, Marie D: 21 articles (11/2010 - 12/2002)
7.	Belperio, John A: 20 articles (03/2013 - 12/2002)
8.	Keane, Michael P: 19 articles (03/2007 - 12/2002)
9.	Li, Fang: 16 articles (06/2022 - 11/2002)
10.	Rahman, Milladur: 15 articles (11/2021 - 04/2009)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "This protection was associated with a significant reduction in hepatic injury, neutrophilic CXC chemokine (Mip-2) expression, neutrophil infiltration, and associated inflammation. " 01/01/2016 - "Novel small molecules targeting neutrophilic inflammation, such as chemokine (CXC) receptor 2 (CXCR2) antagonists reduce neutrophils, but do not improve clinical outcomes in studies to date. " 07/01/2014 - "This study tested the hypothesis that the chemokine (C-X-C motif) receptor 3 (CXCR3) participates in T-cell accumulation in AT of obese mice and thus in the regulation of local inflammation and systemic metabolism. " 09/01/2004 - "In this study, we addressed the possibility that ANIT upregulates CXC chemokines in the liver and that these compounds mediate hepatic inflammation and tissue injury after ANIT treatment. " 04/01/2000 - "This study demonstrates increased sensitivity to a C-X-C chemokine in a model of chronic inflammation, implicates the alpha 4-integrin in neutrophil adhesion, and demonstrates that CD18 mediates leukocyte transendothelial migration independent from firm adhesion."
2.	Neoplasms (Cancer) 12/28/2022 - "Studies have shown that CXC chemokines are dysregulated in multiple types of cancer and are closely correlated with tumor progression. " 12/01/2020 - "In this study, we investigated data related to transcription, translation, survival and tumor immune infiltration for CXC chemokines in patients with CRC from the ONCOMINE, GEPIA, cBioPortal, HPA and TIMER databases. " 12/01/2019 - "Preclinical studies have demonstrated that postirradiation tumor revascularization is dependent on a stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4)-driven process in which myeloid cells are recruited from bone marrow. " 09/01/2018 - "Previous studies have found that the activation of stromal cell‑derived factor‑1 (SDF‑1)/CXC chemokine receptor‑4 (CXCR4)/β‑catenin signaling is associated with biological malignant potential in cancers. " 01/01/2008 - "In the present study we aimed at investigating the expression profile of pro-inflammatory and angiogenic CXC chemokines as potential factors contributing to the aggressive biology of this gastrointestinal malignancy. "
3.	Sepsis (Septicemia) 12/01/2010 - "These data demonstrate that early, local treatment with CXC chemokines enhances neutrophil recruitment and clearance of bacteria as well as improves survival in the CLP model of sepsis." 11/29/2021 - "Targeting S100A9 function decreased formation of CXC chemokines in circulation and lungs and attenuated sepsis-induced lung damage. " 01/01/2019 - "Thus, we aimed to investigate the clinical relevance of CXC chemokine gene polymorphisms and susceptibility to sepsis in a traumatically injured population. " 07/15/2006 - "As a result, CXC chemokines increase in lung, setting the stage for neutrophil accumulation in lung during sepsis." 02/01/2006 - "CC and CXC chemokine levels in children with meningococcal sepsis accurately predict mortality and disease severity."
4.	Ischemia 03/01/2013 - "This study investigated the protective effects of CS in rats post-renal ischemia-reperfusion (I/R) sequence by analyzing the influence on stromal cell-derived factor-1α (SDF-1α and chemokine (C-X-C motif) receptor 4 (CXCR4) expressions and senescence during recovery. " 01/01/1999 - "The objective of current study was to determine whether the CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and KC, contribute to pulmonary neutrophil recruitment and injury following hepatic ischemia/reperfusion. " 02/20/2018 - "Patients with ExMI had a significant decrease in CD34+/chemokine (C-X-C motif) receptor 4 (-18%, P=0.01) after stress that was inversely correlated with the magnitude of ischemia (r=-0.19, P=0.003). " 04/15/2015 - "CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice." 05/01/2014 - "Bone marrow mesenchymal stem cells (MSCs) have been demonstrated to exhibit a reparative role in ischemia reperfusion-injured kidney tissue, and the stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis has been found to play an important role in the migration and homing of MSCs. "
5.	Neoplasm Metastasis (Metastasis) 11/01/2022 - "There are many anti-metastatic agents that can target metastasis-related pathways, but there are relatively few studies on agents targeting C-X-C chemokine receptor type 4 (CXCR4) signaling axis. " 08/01/2017 - "Numerous studies have demonstrated a marked association between high C-X-C chemokine receptor 4 (CXCR4) expression and the invasiveness, progression and metastasis of HCC. " 06/01/2014 - "The present study was designed to investigate the correlation between C-X-C chemokine receptor type 4 (CXCR4) expression and brain-specific metastasis of NSCLC. " 02/01/2006 - "Our study indicates for the first time that the CXC chemokine MIP-2 promotes angiogenesis and growth of colorectal CT26.WT hepatic metastasis." 12/23/2022 - "Mechanistically, KDM6B promotes GC cells proliferation and metastasis through its enzymatic activity through the induction of H3K27me3 demethylation near the CXCR4 (C-X-C chemokine receptor type 4) promoter region, resulting in the upregulation of CXCR4 expression. "

Related Drugs and Biologics

1.	Ligands
2.	Chemokines
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Proteins (Proteins, Gene)
5.	Cytokines
6.	Chemotactic Factors
7.	Vaccines
8.	Alanine Transaminase (SGPT)
9.	Interferons
10.	Interleukins

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Ligation
3.	Punctures
4.	Precision Medicine
5.	Cell- and Tissue-Based Therapy (Cell Therapy)