CC Chemokines

Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.

Also Known As:

Chemokines, CC; C-C Chemokines; C C Chemokine; C C Chemokines; Chemokine, C-C; Chemokine, CC; Chemokines, C-C; beta Chemokine; beta Chemokines; C-C Chemokine; CC Chemokine; beta-Chemokine; beta-Chemokines

Networked: 2380 relevant articles (51 outcomes, 226 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tang, Chih-Hsin: 12 articles (11/2021 - 03/2009)
2.	Kuziel, William A: 10 articles (12/2006 - 04/2003)
3.	Douglas, Steven D: 10 articles (05/2004 - 04/2002)
4.	Ho, Wen-Zhe: 9 articles (01/2021 - 11/2002)
5.	Bursill, Christina A: 8 articles (01/2021 - 01/2003)
6.	Rollins, Barrett J: 8 articles (01/2016 - 05/2003)
7.	Mukaida, Naofumi: 7 articles (12/2021 - 01/2004)
8.	Hassanshahi, Gholamhossein: 7 articles (03/2021 - 01/2013)
9.	Graham, Gerard J: 7 articles (01/2021 - 07/2006)
10.	Trautwein, Christian: 7 articles (01/2020 - 03/2003)

Related Diseases

1.	Infections 02/01/2005 - "High production of beta-chemokines and CD8+ T cell anti-viral factors in naive as well as in vaccinated macaques has been associated with complete or partial protection against SIV infection indicating that genetic or environmental factors may influence their production. " 07/01/1999 - "It has been controversial whether CD34+ stem cells are susceptible to HIV-1 infection and whether high levels of beta-chemokines are beneficial for suppressing HIV-1 infection during DC maturation. " 04/01/2000 - "A non-cognate mechanism of protection against human immunodeficiency virus-1 (HIV-1) infection involves up-regulation of beta-chemokines, which bind and may down-modulate the CCR5 co-receptors, thereby preventing transmission of M-tropic HIV-1. " 06/18/1999 - "Protection against parenteral HIV-1 infection by homozygous deletion in the C-C chemokine receptor 5 gene." 11/01/2022 - "These studies suggested that CC chemokines were essential in immune system evolution and not monofunctional during pathogen infection."
2.	Inflammation (Inflammations) 01/01/2015 - "C-C chemokine receptor 2 inhibitor ameliorates hepatic steatosis by improving ER stress and inflammation in a type 2 diabetic mouse model." 01/01/2018 - "The purpose of this study was to determine the involvement of inflammation-associated chemokines (CC series) in the pathogenesis of nonspecific LBP and to evaluate the effect of SMT on that process. " 04/25/2012 - "A number of recent studies have speculated that the C-C chemokine receptor type 7 (CCR7), plays important roles in immune-cell trafficking in various tissue compartments during inflammation and in immune surveillance. " 10/15/2006 - "m35K may be a useful tool to study the role of CC chemokines in leukocyte trafficking and block the recruitment of monocytes in chronic inflammation." 12/01/2004 - "The aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. "
3.	Neoplasms (Cancer) 03/01/2016 - "C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer." 10/01/2018 - "In this study, we first analyzed the levels of miR-199a and C-C chemokine receptor 7 (CCR7) in the tumor tissues and tumor-adjacent tissues, and found that the level of miRNA-199a was lower, whereas the level of CCR7 was higher in tumor tissues. " 11/14/2023 - "C-C chemokine receptor 5 (CCR5) plays a crucial role in the regulation of immune cell activation and migration as well as the progression of many cancers. " 10/27/2023 - "While C-C chemokine receptor 8 (CCR8) has been investigated as a candidate anti-cancer target, comprehensive multi-omics analyzes across various indications are limited. " 06/26/2023 - "CC chemokine 2 (CCL2) is a multifunctional factor associated with the progression of numerous cancers. "
4.	Insulin Resistance 04/01/2013 - "Although recent human studies have shown upregulation of the expression of not only MCP-1-CCR2 but also other CC chemokines and their receptors in the visceral fat of obese individuals, it is not known if CCR5 is involved in ATM recruitment and insulin resistance. " 03/31/2010 - "C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice." 01/01/2017 - "α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2." 05/01/2020 - "CC chemokine ligand 18 (CCL 18) secreted from white adipose tissue is upregulated in individuals with insulin resistance. " 01/01/2021 - "We reported previously that C-C chemokine receptors 2 and 5 promote obesity-associated adipose tissue inflammation and insulin resistance. "
5.	Fibrosis (Cirrhosis) 08/01/2003 - "We attempted to study the expression of C-C chemokines and their correlation with CD68-positive macrophages in crescentic glomeruli to investigate further their possible roles in crescent formation and progression to fibrosis in different types of human CGN. " 12/03/2021 - "Macrophage depletion in CCR2 (C-C chemokine receptor type 2) knockout mice showed that aggravated fibrosis was primarily caused by the recruitment of monocyte-derived macrophages. " 01/01/2013 - "We here aimed to investigate the effects of the CC chemokine CCL3, also known as macrophage inflammatory protein-1α, in two different fibrosis models. " 09/01/2004 - "Together, these data suggest that CCL7 is highly expressed in biopsies and pulmonary fibroblast lines obtained from patients with UIP relative to patients with other IIP and patients without IIP, and that this CC chemokine may have a major role in the progression of fibrosis in this IIP patient group." 06/01/2004 - "Parallel expression analysis of genes using microarrays has provided insight into novel mediators of fibrosis including the C-C chemokine MCP-3. "

Related Drugs and Biologics

1.	Ligands
2.	Chemokines
3.	Chemokine CCL5
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Chemokine CCL4
6.	Proteins (Proteins, Gene)
7.	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)
8.	Chemokine CCL3
9.	Monoclonal Antibodies
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Highly Active Antiretroviral Therapy (HAART)
4.	Ligation
5.	Castration