HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Tissue Inhibitor of Metalloproteinase-2

A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Also Known As:
Metalloproteinase-2 Tissue Inhibitor; Tissue Inhibitor of Metalloproteinase 2; TIMP-2
Networked: 1092 relevant articles (34 outcomes, 183 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Stetler-Stevenson, William G: 13 articles (11/2014 - 07/2004)
2. Turpeenniemi-Hujanen, Taina: 13 articles (01/2013 - 01/2004)
3. Tanus-Santos, Jose E: 7 articles (01/2015 - 07/2008)
4. Yang, Shun-Fa: 7 articles (09/2013 - 07/2002)
5. Mroczko, Barbara: 6 articles (04/2014 - 07/2010)
6. Szmitkowski, Maciej: 6 articles (04/2014 - 07/2010)
7. Wei, Beiyang: 6 articles (01/2013 - 12/2004)
8. Jaworski, Diane M: 6 articles (04/2011 - 05/2005)
9. Jensen-Taubman, Sandra: 5 articles (01/2014 - 11/2011)
10. Bourboulia, Dimitra: 5 articles (01/2014 - 11/2011)

Related Diseases

1. Neoplasms (Cancer)
2. Liver Cirrhosis (Hepatic Cirrhosis)
3. Carcinoma (Carcinomatosis)
4. Fibrosis (Cirrhosis)
5. Thyroid Neoplasms (Thyroid Cancer)

Related Drugs and Biologics

1. Tissue Inhibitor of Metalloproteinase-1
2. Tissue Inhibitor of Metalloproteinases (TIMP)
3. Messenger RNA (mRNA)
4. Matrix Metalloproteinase 2 (Gelatinase A)
5. Matrix Metalloproteinase 14 (MT1-MMP)
6. Collagen
7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8. Collagen Type I (Type I Collagen)
9. Matrix Metalloproteinase 9 (Gelatinase B)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Transplants (Transplant)
2. Heterologous Transplantation (Xenotransplantation)
3. Breast Implants (Breast Implant)
4. Cystectomy
5. Ligation